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Modulare hybride Wirkstoff trans porter auf der Basis bakterieller Toxine

Molekulare Medizin

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Abstract

The targeted delivery of pharmacologically active molecules into the cytosol of mammalian cells is a central goal of experimental pharmacology and pharmacotherapy. By coupling cell-permeable bacterial protein toxins to streptavidin, we generated modular hybrid protein carriers for specific delivery of biotin-labelled molecules into the cytosol of target cells.

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Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Universitätsklinikum Ulm, Ulm, Deutschland

    Holger Barth

  2. Institut für Organische Chemie III, Universität Ulm, Ulm, Deutschland

    Tanja Weil

  3. Institut für Pharmakologie und Toxikologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 11, D-89081, Ulm, Deutschland

    Holger Barth

  4. Institut für Organische Chemie III, Universität Ulm, Albert-Einstein-Allee 11, D-89081, Ulm, Deutschland

    Tanja Weil

Authors
  1. Holger Barth
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  2. Tanja Weil
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Correspondence to Holger Barth.

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Holger Barth Jahrgang 1965. 1986–1991 Biologiestudium an der TU Darmstadt. 1992–1994 Dissertation am Deutschen Krebsforschungszentrum (DKFZ), Heidelberg. 1995–2004 Arbeitsgruppenleiter am Institut für Experimentelle und Klinische Pharmakologie und Toxikologie an der Universität Freiburg. 2002 Habilitation. 2005 Fachtoxikologe DGPT. Seit 2004 C3-Professor für Pharmakologie und Toxikologie an der Universität Ulm. 2010 Forschungspreis der der Deutschen Gesellschaft für Toxikologie (GT), seit 2011 stellvertretender Vorsitzender der GT.

Tanja Weil Jahrgang 1973. 1993–1998 Chemiestudium an der TU Braunschweig und der Université de Bordeaux I, Frankreich. 2002 Dissertation am Max-Planck-Institut für Polymerforschung, Mainz. 2002–2008 Gruppenleiterin, Abteilungsleiterin und zuletzt Director of Chemical R&D bei der Firma Merz Pharmaceuticals in Frankfurt a. M. 2008 Associate Professor an der National University of Singapore. Seit 2010 W3-Professorin und Leiterin des Instituts für Organische Chemie III an der Universität Ulm. Seit 2013 Inhaberin eines Synergy Grants des Europäischen Forschungsrats.

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Barth, H., Weil, T. Modulare hybride Wirkstoff trans porter auf der Basis bakterieller Toxine. Biospektrum 20, 22–25 (2014). https://doi.org/10.1007/s12268-014-0400-y

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  • DOI: https://doi.org/10.1007/s12268-014-0400-y

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