Abstract
Type 1 pili are extracellular, supramolecular protein complexes required for the attachment of pathogenic E. coli strains to host cells. Hundreds to thousands of protein subunits are assembled within minutes in vivo and form filaments with unique kinetic stability against dissociation. Here, we review recent work on the structure, assembly mechanism and potential technical applications derived from this exciting biological system.
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Christoph Giese 2000–2005 Biochemiestudium an der Universität Halle-Wittenberg. 2006–2011 Promotion an der ETH Zürich, Schweiz, dort seit 2011 Postdoktorand.
Rudi Glockshuber 1979–1985 Chemiestudium an der LMU München und am Max-Planck-Institut für Biochemie, Martinsried. 1985–1989 Promotion am Genzentrum der LMU München. 1989–1994 Postdoktorand an der Universität Regensburg. 1994–1997 Tenure-Track-Assistenzprofessor an der ETH Zürich, Schweiz. 1997–2000 Außr — ordentlicher Professor an der ETH Zürich. Seit 2000 Ordentlicher Professor für Molekularbiologie an der ETH Zürich.
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Giese, C., Glockshuber, R. Struktur, Assemblierung und Stabilität von Typ-1-Pili. Biospektrum 19, 492–495 (2013). https://doi.org/10.1007/s12268-013-0343-8
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DOI: https://doi.org/10.1007/s12268-013-0343-8