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Tumorzellen — Vehikel mit defekten Bremsen

Fehlerhafte Regulation von Protein-Tyrosinphosphatasen

  • Wissenschaft · Special: Zellbiologie
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Abstract

Protein tyrosine phosphatases (PTP) counteract the enzymatic activity of protein tyrosine kinases. Impaired activity of some members of the PTP family has been found in cancer cells of different malignancies. We have characterized defects in the function of a PTP which negatively regulates the receptor tyrosine kinases FLT3 (Fms-like tyrosine kinase 3), and PDGFR (platelet-derived growth factor receptor) in acute myeloid leukaemia and meningioma cells.

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Authors and Affiliations

  1. Institut für Molekulare Zellbiologie, Universitätsklinikum Jena, Jena, Germany

    Jörg P. Müller, Astrid Petermann & Frank-D. Böhmer

  2. Institut für Neuropathologie, Universitätsklinikum Magdeburg, Magdeburg, Germany

    Christian Mawrin

  3. Zentrum für Molekulare Biomedizin Institut für Molekulare Zellbiologie, Universitätsklinikum Jena, Hans-Knöll-Straße 2, D-07745, Jena, Germany

    Jörg P. Müller

Authors
  1. Jörg P. Müller
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  2. Astrid Petermann
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  3. Christian Mawrin
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  4. Frank-D. Böhmer
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Corresponding author

Correspondence to Jörg P. Müller.

Additional information

Jörg P. Müller Biologiestudium an den Universitäten Rostock und Dresden. 1984-1987 Arzneimittelwerk Dresden. 1988–1991 Zentralinstitut für Mikrobiologie und experimentelle Therapie in Jena, DDR-Akademie der Wissenschaften, 1989 Promotion (Dr. rer. nat.). 1991–1995 Postdoc in Groningen, Niederlande und Newcastle, UK. 1996–2002 Assistenz an der Biologisch-Pharmazeutischen Fakultät an der Universität Jena, 2001 Habilitation im Fach Molekularbiologie. Seit 2003 Institut für Molekulare Zellbiologie, Universitätsklinikum Jena.

Christian Mawrin 1992–1998 Medizinstudium an der Universität Magdeburg. 2000 Promotion (Dr. med.). 2005 Facharzt für Neuropathologie und Habilitation. 2006–2008 W2-Professur und Leitung der Abteilung Neuropathologie am Universitätsklinikum Jena. Seit 2008 Direktor des Instituts für Neuropathologie, Universitätsklinikum Magdeburg.

Astrid Petermann Biochemiestudium an der Universität Jena, 2007–2010 Promotion (Dr. rer. nat.) am Institut für Molekulare Zellbiologie, Universitätsklinikum Jena. 2011 Postdoc in der AG Experimentelle Rheumatologie, Universitätsklinikum Jena, anschließend am Institut für Molekulare Zellbiologie.

Frank-D. Böhmer 1975 Biochemiestudium, Universität Halle, 1980 Promotion (Dr. rer. nat.), Zentralinstitut für Molekularbiologie, Berlin-Buch, DDR-Akademie der Wissenschaften. 1992–1997 Projektleiter, Max-Planck-Arbeitsgruppe „Signaltransduktion von Wachstumsfaktoren“, Jena. 1995 Habilitation in Biochemie. Seit 2001 Dozent für Molekulare Zellbiologie, Institut für Molekulare Zellbiologie am Universitätsklinikum Jena.

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Müller, J.P., Petermann, A., Mawrin, C. et al. Tumorzellen — Vehikel mit defekten Bremsen. Biospektrum 18, 394–397 (2012). https://doi.org/10.1007/s12268-012-0200-1

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  • DOI: https://doi.org/10.1007/s12268-012-0200-1

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