Abstract
We show that mutation of fibroblast growth factor receptor 1a simultaneously increases aggression, boldness and exploration in adult zebrafish. Reduction of Fgf signalling is correlated with a reduction of histamine levels in the mutant brain. Pharmacological increase of histaminergic signalling rescues the behavioural phenotype. This work demonstrates that a single genetic locus can link three components of the aggressionboldness behavioural syndrome.
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Laure Bally-Cuif Jahrgang 1967. 1987–1991 Studium der Molekular-und Zellbiologie an der Ecole Normale Supérieure und der Universität Paris, Frankreich. 1994 Promotion am Hopital de la Salpêtrière, Paris. 1995–1997 Postdoc Princeton University (USA). 1997–2009 Gruppenleiterin und Abteilungsleiterin am Helmholtz-Zentrum München. Ab 2009 Forschungsdirektorin am CNRS in Gifsur-Yvette, Frankreich.
William H. J. Norton Jahrgang 1978. Studium der Biologie an der University of Sheffield, UK. 2002 Promotion am University College London, UK. 2002–2005 Postdoc am EMBL in Heidelberg und im Labor von Dr. L. Bally-Cuif. 2006–2009 Helmholtz-Zentrum München. Seit 2009 CNRS in Gif-sur-Yvette, Frankreich.
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Norton, W.H.J., Bally-Cuif, L. Die Zebrafisch fgfr1a-Mutante zeigt eine genetische Basis der Aggression. Biospektrum 18, 46–48 (2012). https://doi.org/10.1007/s12268-012-0143-6
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DOI: https://doi.org/10.1007/s12268-012-0143-6