Abstract
Late stage enzymatic prenylation and methylation are means to diversify (natural) compounds and to specify their functions. In eukaryotes and microbes, these steps are performed by large enzyme families, the prenyl and methyl transferases, which modify various types of small molecules, like isoprenoids, phenolics or alkaloids, but also DNA and proteins. We investigate the theoretical basis of these processes and possible commercial applications in synthetic chemistry.
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Ludger A. Wessjohann Chemiestudium. 1987–1990 Promotion, Universität Hamburg. 1990–1991 Postdoc, Stanford University, CA, USA. 1992–1998 Habilitation, LMU München. 1998–2000 Full Professor, Vrije Universität, Amsterdam, Niederlande. Seit 2000 Direktor der Abteilung Natur- und Wirkstoffchemie am Leibniz-Institut für Pflanzenbiochemie (IPB) und Lehrstuhl für Naturstoffchemie an der Universität Halle-Wittenberg. Seit 2010 Geschäftsführender Direktor des IPB.
Julia Kufka Jahrgang 1982. 2003–2007 Biologiestudium, TU Braunschweig. Seit 2007 Promotion am IPB, Abteilung Natur- und Wirkstoffchemie.
Thomas Vogt Biologiestudium. 1986–1989 Promotion, Universität zu Köln. 1990–1992 Postdoc, Universität von British Columbia, Vancouver, Kanada. 1992–1993 Postdoc, Washington State University, Pullman, WA, USA. Seit 1993 Gruppenleiter am IPB, Abteilung Stoffwechsel- und Zellbiologie. 2006 Habilitation in Biochemie an der Universität Halle-Wittenberg.
Robert Klein Jahrgang 1981. 2001–2007 Bioinformatikstudium, Universität Halle-Wittenberg. Seit 2008 Promotion am IPB, Abteilung Natur- und Wirkstoffchemie.
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Wessjohann, L., Vogt, T., Kufka, J. et al. Prenyl- und Methyltransferasen in Natur und Synthese. Biospektrum 18, 22–25 (2012). https://doi.org/10.1007/s12268-012-0137-4
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DOI: https://doi.org/10.1007/s12268-012-0137-4