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Acute Cardiovascular Effects of Non-Invasive Electrical Spinal Cord Stimulation: Results from a Pilot Study in Humans

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Abstract

We aimed to determine if non-invasive electrical spinal cord stimulation (NIE-SCS) is associated with acute changes in systemic and pulmonary hemodynamics and cardiac electrophysiology at rest. Nine subjects without structural heart disease referred for catheter ablation of cardiac arrhythmia were included. NIE-SCS was performed in each patient at vertebral levels T1, T7, and T11. Higher systolic BP (BPs) was detected during T1 NIE-SCS as compared with baseline (147.9 ± 22.5 vs 135.4 ± 17.4 mmHg; P = 0.02). Atrioventricular nodal effective refractory period (AVN ERP) was shorter during stimulation at T1 and T7, when compared with baseline values (baseline 303.3 ± 15.0 vs 272.0 ± 19.2 for T1 vs 278.0 ± 8.3 ms for T7; P < 0.05). NIE-SCS at the T1 level is associated with an elevation of BPs. NIE-SCS at the T1 and T7 levels shortens AVN ERP. Further studies are needed for the evaluation of chronic effects.

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Funding

The authors would like to thank the financial support from the program “Basic research for the long-term development and ensuring the competitiveness of society and the state” (# 63.4, (0113-2019-0006)) and the research grant RBRF 18-315-20050.

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Authors and Affiliations

  1. Neuromodulation lab, Arrhythmia Department, Almazov National Medical Research Centre, 2, Akkuratova str., Saint-Petersburg, Russia, 194341

    Evgeny N. Mikhaylov, Svetlana V. Garkina, Natalia N. Belyaeva & Dmitry S. Lebedev

  2. Pavlov Institute of Physiology of Russian Academy of Sciences, Saint Petersburg, Russia

    Tatiana R. Moshonkina

  3. Polenov Research Institute of Neurosurgery, Almazov National Medical Research Centre, Saint Petersburg, Russia

    Elena N. Zharova & Pavel D. Kovzelev

  4. Circulation Physiology Department, Almazov National Medical Research Centre, Saint Petersburg, Russia

    Andrey V. Kozlenok

  5. Heart and Vessels Institute, Almazov National Medical Research Centre, Saint Petersburg, Russia

    Evgeny V. Shlyakhto

Authors
  1. Evgeny N. Mikhaylov
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  2. Tatiana R. Moshonkina
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  3. Elena N. Zharova
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  4. Svetlana V. Garkina
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  5. Pavel D. Kovzelev
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  6. Natalia N. Belyaeva
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  7. Andrey V. Kozlenok
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  8. Dmitry S. Lebedev
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  9. Evgeny V. Shlyakhto
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Corresponding author

Correspondence to Evgeny N. Mikhaylov.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The study protocol and patient informed consent form were reviewed and approved by the Almazov National Medical Research Centre Ethics Committee (03/03/2018, protocol #59). The study was conducted in accordance with the Helsinki declaration. All patients provided written consent to participate in the study.

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Associate Editor Ana Barac oversaw the review of this article

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Mikhaylov, E.N., Moshonkina, T.R., Zharova, E.N. et al. Acute Cardiovascular Effects of Non-Invasive Electrical Spinal Cord Stimulation: Results from a Pilot Study in Humans. J. of Cardiovasc. Trans. Res. 13, 891–893 (2020). https://doi.org/10.1007/s12265-020-10014-7

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  • DOI: https://doi.org/10.1007/s12265-020-10014-7

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