APA. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition. Washington, DC: American Psychiatric Association, 2013.
Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry 2008, 47: 921–929.
PubMed
Article
Google Scholar
Mannion A, Leader G. An investigation of comorbid psychological disorders, sleep problems, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder: A two year follow-up. Res Autism Spectr Disord 2016, 22: 20–33.
Article
Google Scholar
Mannion A, Leader G. Comorbidity in autism spectrum disorder: A literature review. Res Autism Spectr Disord 2013b, 7: 1595–1616.
Article
Google Scholar
Bauman ML. Medical comorbidities in autism: Challenges to diagnosis and treatment. Neurotherapeutics 2010, 7: 320–327.
PubMed
PubMed Central
Article
Google Scholar
Zerbo O, Leong A, Barcellos L, Bernal P, Fireman B, Croen LA. Immune mediated conditions in autism spectrum disorders. Brain Behav Immun 2015, 46: 232–236.
CAS
PubMed
PubMed Central
Article
Google Scholar
Goines P, Van de Water J. The immune system’s role in the biology of autism. Curr Opin Neurol 2010, 23: 111–117.
PubMed
Article
Google Scholar
Masi A, Quintana DS, Glozier N, Lloyd AR, Hickie IB, Guastella AJ. Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis. Mol Psychiatry 2015, 20: 440–446.
CAS
PubMed
Article
Google Scholar
Mead J, Ashwood P. Evidence supporting an altered immune response in ASD. Immunol Lett 2015, 163: 49–55.
CAS
PubMed
Article
Google Scholar
Owen JA, Punt J, Stranford SA, Jones PP, Kuby J. Kuby Immunology. New York: W.H. Freeman, 2013.
Google Scholar
D’Elia RV, Harrison K, Oyston PC, Lukaszewski RA, Clark GC. Targeting the “cytokine storm” for therapeutic benefit. Clin Vaccine Immunol 2013, 20: 319–327.
PubMed
PubMed Central
Article
Google Scholar
Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, et al. Innate or adaptive immunity? the example of natural killer cells. Science 2011, 331: 44–49.
CAS
PubMed
PubMed Central
Article
Google Scholar
Turner MD, Nedjai B, Hurst T, Pennington DJ. Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2014, 1843: 2563–2582.
CAS
Google Scholar
Graves DT, Jiang Y. Chemokines, a family of chemotactic cytokines. Crit Rev Oral Biol Med 1995, 6: 109–118.
CAS
PubMed
Article
Google Scholar
Depino MA, de los Angeles Robinson-Agramonte M. Understanding on neuroimmunology in autism spectrum disorder. Translational approaches to autism spectrum disorder. Springer International Publishing, 2015: 155–180.
Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations. Annu Rev Immunol 2010, 28: 445–489.
CAS
PubMed
PubMed Central
Article
Google Scholar
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell. 4th edition. New York: Garland Science; 2002. Helper T Cells and Lymphocyte Activation.
Gupta S, Aggarwal S, Rashanravan B, Lee T. Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol 1998, 85: 106–109.
CAS
PubMed
Article
Google Scholar
Molloy CA, Morrow AL, Meinzen-Derr J, Schleifer K, Dienger K, Manning-Courtney P, et al. Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol 2006, 172: 198–205.
CAS
PubMed
Article
Google Scholar
Romagnani S. T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol 2000, 85: 9–21.
CAS
PubMed
Article
Google Scholar
Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don’t know. Cell Res 2006, 16: 126–133.
CAS
PubMed
Article
Google Scholar
Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004, 75: 163–189.
CAS
PubMed
Article
Google Scholar
Xu N, Li X, Zhong Y. Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders. Mediators Inflamm 2015, 2015: 10.
Google Scholar
Cavaillon JM. Pro- versus anti-inflammatory cytokines: Myth or reality. Cell Mol Biol (Noisy-le-grand) 2001, 47: 695–702.
CAS
PubMed
Google Scholar
Filiano AJ, Gadani SP, Kipnis J. Interactions of innate and adaptive immunity in brain development and function. Brain Res 2015, 1617: 18–27.
CAS
PubMed
Article
Google Scholar
Hart BL. Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988, 12: 123–137.
CAS
PubMed
Article
Google Scholar
Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008, 9: 46–56.
CAS
PubMed
PubMed Central
Article
Google Scholar
Dantzer R. Cytokine, sickness behavior, and depression. Immunol. Allergy Clin North Am 2009, 29: 247–264.
PubMed
PubMed Central
Article
Google Scholar
Dantzer R. Cytokine-Induced Sickness Behavior: Where Do We Stand? Brain Behav Immun 2001, 15: 7–24.
CAS
PubMed
Article
Google Scholar
Capuron L, Miller AH. Immune system to brain signaling: neuropsychopharmacological implications. Pharmacology & therapeutics 2011, 130: 226–238.
CAS
Article
Google Scholar
Denicoff KD, Rubinow DR, Papa MZ, Simpson C, Seipp CA, Lotze MT, et al. The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med 1987, 107: 293–300.
CAS
PubMed
Article
Google Scholar
Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010, 67: 446–457.
CAS
PubMed
Article
Google Scholar
Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 2011, 70: 663–671.
CAS
PubMed
PubMed Central
Article
Google Scholar
Modabbernia A, Taslimi S, Brietzke E, Ashrafi M. Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 2013, 74: 15–25.
CAS
PubMed
Article
Google Scholar
Capuron L, Castanon N. Role of inflammation in the development of neuropsychiatric symptom domains: evidence and mechanisms. Curr Top Behav Neurosci 2017, 31: 31–44.
Mitchell RH, Goldstein BI. Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review. J Am Acad Child Adolesc Psychiatry 2014, 53: 274–296.
PubMed
Article
Google Scholar
Tilleux S, Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 2007, 85: 2059–2070.
CAS
PubMed
Article
Google Scholar
Rubenstein JL, Merzenich MM. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav 2003, 2: 255–267.
CAS
PubMed
Article
Google Scholar
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. Structural and functional features of central nervous system lymphatic vessels. Nature 2015, 523: 337–341.
CAS
PubMed
PubMed Central
Article
Google Scholar
Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Altered T cell responses in children with autism. Brain Behav Immun 2011, 25: 840–849.
CAS
PubMed
Article
Google Scholar
Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, et al. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature 2016, 535: 425–429.
CAS
PubMed
PubMed Central
Article
Google Scholar
Forbes CE, Grafman J. The role of the human prefrontal cortex in social cognition and moral judgment. Annu Rev Neurosci 2010, 33: 299–324.
CAS
PubMed
Article
Google Scholar
Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen R, Pessah IN, et al. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun 2009, 23: 124–133.
CAS
PubMed
Article
Google Scholar
Stubbs EG, Crawford ML. Depressed lymphocyte responsiveness in autistic children. J Autism Child Schizophr 1977, 7: 49–55.
CAS
PubMed
Article
Google Scholar
Meltzer A, Van de Water J. The role of the immune system in autism spectrum disorder. Neuropsychopharmacology 2017, 42: 284–298.
PubMed
Article
Google Scholar
Atladottir HO, Thorsen P, Ostergaard L, Schendel DE, Lemcke S, Abdallah M, et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord 2010, 40: 1423–1430.
PubMed
Article
Google Scholar
Jiang HY, Xu LL, Shao L, Xia RM, Yu ZH, Ling ZX, et al. Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis. Brain Behav Immun 2016, 58: 165–172..
PubMed
Article
Google Scholar
Estes ML, McAllister AK. Maternal immune activation: Implications for neuropsychiatric disorders. Science 2016, 353: 772–777.
CAS
PubMed
Article
Google Scholar
Krakowiak P, Goines PE, Tancredi DJ, Ashwood P, Hansen RL, Hertz-Picciotto I, et al. Neonatal cytokine profiles associated with autism spectrum disorder. Biol Psychiatry 2017, 81: 442–451..
CAS
PubMed
Article
Google Scholar
Atladottir HO, Pedersen MG, Thorsen P, Mortensen PB, Deleuran B, Eaton WW, et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 2009, 124: 687–694.
PubMed
Article
Google Scholar
Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S. Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. PLoS One 2011, 6: e20470.
CAS
PubMed
PubMed Central
Article
Google Scholar
Netea MG, Simon A, van de Veerdonk F, Kullberg B-J, Van der Meer JWM, Joosten LAB. IL-1β Processing in Host Defense: Beyond the Inflammasomes. PLoS Pathog 2010, 6: e1000661.
PubMed
PubMed Central
Article
Google Scholar
Li L, Kim J, Boussiotis VA. IL-1beta-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol 2010, 185: 4148–4153.
CAS
PubMed
PubMed Central
Article
Google Scholar
Verma ND, Hall BM, Plain KM, Robinson CM, Boyd R, Tran GT, et al. Interleukin-12 (IL-12p70) Promotes Induction of Highly Potent Th1-Like CD4(+)CD25(+) T Regulatory Cells That Inhibit Allograft Rejection in Unmodified Recipients. Front Immunol 2014, 5: 190.
PubMed
PubMed Central
Article
Google Scholar
Ricci S, Businaro R, Ippoliti F, Lo Vasco VR, Massoni F, Onofri E, et al. Altered cytokine and BDNF levels in autism spectrum disorder. Neurotox Res 2013, 24: 491–501.
CAS
PubMed
Article
Google Scholar
Chez MG, Dowling T, Patel PB, Khanna P, Kominsky M. Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatr Neurol 2007, 36: 361–365.
PubMed
Article
Google Scholar
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 2011, 1813: 878–888.
CAS
PubMed
Article
Google Scholar
Croonenberghs J, Bosmans E, Deboutte D, Kenis G, Maes M. Activation of the inflammatory response system in autism. Neuropsychobiology 2002, 45: 1–6.
CAS
PubMed
Article
Google Scholar
Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2005, 57: 67–81.
CAS
PubMed
Article
Google Scholar
Li X, Chauhn A, Shiekh AM, Patil S, Chauhn V, Li X-M, et al. Elevated immune response in the brain of autistic patients. J Neuroimmunol 2009, 207: 111–116.
CAS
PubMed
PubMed Central
Article
Google Scholar
Wei H, Zou H, Sheikh AM, Malik M, Dobkin C, Brown WT, et al. IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation. J Neuroinflammation 2011, 8: 52.
CAS
PubMed
PubMed Central
Article
Google Scholar
Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2011a, 25: 40–45.
PubMed
Article
Google Scholar
Wei H, Chadman KK, McCloskey DP, Sheikh AM, Malik M, Brown WT, et al. Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors. Biochim Biophys Acta 2012, 1822: 831–842.
CAS
PubMed
Article
Google Scholar
Miano S, Giannotti F, Cortesi F. Sleep disorders and autism spectrum disorder. In: Mazzone L, Vitiello B (Eds.). Psychiatric symptoms and comorbidities in autism spectrum disorder. Springer International Publishing, 2016: 111–128.
Rohleder N, Aringer M, Boentert M. Role of interleukin-6 in stress, sleep, and fatigue. Ann N Y Acad Sci 2012, 1261: 88–96.
CAS
PubMed
Article
Google Scholar
McDougle CJ, Landino SM, Vahabzadeh A, O’Rourke J, Zurcher NR, Finger BC, et al. Toward an immune-mediated subtype of autism spectrum disorder. Brain Res 2015, 1617: 72–92.
CAS
PubMed
Article
Google Scholar
Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, et al. Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol 2008, 204: 149–153.
CAS
PubMed
PubMed Central
Article
Google Scholar
El Gohary TM, El Aziz NA, Darweesh M, Sadaa ES. Plasma level of transforming growth factor β 1 in children with autism spectrum disorder. Egyptian Journal of Ear, Nose, Throat and Allied Sciences 2015, 16: 69–73.
Article
Google Scholar
Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol 2011b, 232: 196–199.
PubMed
Article
Google Scholar
Biber K, Vinet J, Boddeke HWGM. Neuron-microglia signaling: Chemokines as versatile messengers. J Neuroimmunol 2008, 198: 69–74.
CAS
PubMed
Article
Google Scholar
Goines PE, Ashwood P. Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol Teratol 2013, 36: 67–81.
CAS
PubMed
Article
Google Scholar
Courchesne E. Brain development in autism: Early overgrowth followed by premature arrest of growth. Ment Retard Dev Disabil Res Rev 2004, 10: 106–111.
PubMed
Article
Google Scholar
Bickel M. The role of interleukin-8 in inflammation and mechanisms of regulation. J Periodontol 1993, 64: 456–460.
CAS
PubMed
Google Scholar
Qazi BS, Tang K, Qazi A. Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis. Int J Inflam 2011, 2011: 908468.
PubMed
PubMed Central
Article
Google Scholar
Ashwood P, Corbett BA, Kantor A, Schulman H, Van de Water J, Amaral DG. In search of cellular immunophenotypes in the blood of children with autism. PLoS One 2011c, 6: e19299.
PubMed
Article
Google Scholar
Enstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL, et al. Increased IgG4 levels in children with autism disorder. Brain Behav Immun 2009, 23: 389–395.
CAS
PubMed
Article
Google Scholar
Heuer L, Ashwood P, Schauer J, Goines P, Krakowiak P, Hertz-Picciotto I, et al. Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res 2008, 1: 275–283.
PubMed
PubMed Central
Article
Google Scholar
Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin Pharmacol Ther 2001, 69: 89–95.
Article
Google Scholar
Banati R, Hickie IB. Therapeutic signposts: using biomarkers to guide better treatment of schizophrenia and other psychotic disorders. Med J Aust 2009, 190: S26.
PubMed
Google Scholar
Ruggeri B, Sarkans U, Schumann G, Persico A. Biomarkers in autism spectrum disorder: the old and the new. Psychopharmacology (Berl.) 2014, 231: 1201–1216.
CAS
Article
Google Scholar
Akhondzadeh S, Fallah J, Mohammadi MR, Imani R, Mohammadi M, Salehi B, et al. Double-blind placebo-controlled trial of pentoxifylline added to risperidone: effects on aberrant behavior in children with autism. Prog. Neuropsychopharmacol. Biol Psychiatry 2010, 34: 32–36.
CAS
PubMed
Article
Google Scholar
Ghaleiha A, Rasa SM, Nikoo M, Farokhnia M, Mohammadi M-R, Akhondzadeh S. A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism. Psychiatry Res 2015, 229: 181–187.
CAS
PubMed
Article
Google Scholar
Kobayashi T, Notoya K, Naito T, Unno S, Nakamura A, Martel-Pelletier J, et al. Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum 2005, 52: 479–487.
CAS
PubMed
Article
Google Scholar
Mandrekar-Colucci S, Karlo JC, Landreth GE. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci 2012, 32: 10117–10128.
CAS
PubMed
PubMed Central
Article
Google Scholar
Asadabadi M, Mohammadi MR, Ghanizadeh A, Modabbernia A, Ashrafi M, Hassanzadeh E, et al. Celecoxib as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial. Psychopharmacology (Berl.) 2013, 225: 51–59.
CAS
Article
Google Scholar
Choi JE, Widjaja F, Careaga M, Bent S, Ashwood P, Hendren RL. Change in plasma cytokine levels during risperidone treatment in children with autism. J Child Adolesc Psychopharmacol 2014, 24: 586–589.
CAS
PubMed
PubMed Central
Article
Google Scholar
Hayashi-Takagi A, Vawter MP, Iwamoto K. Peripheral biomarkers revisited: integrative profiling of peripheral samples for psychiatric research. Biol Psychiatry 2014, 75: 920–928.
CAS
PubMed
Article
Google Scholar
Insel TR. The NIMH research domain criteria (RDoC) project: precision medicine for psychiatry. Am J Psychiatry 2014, 171: 395–397.
PubMed
Article
Google Scholar
National Academy of Sciences. The national academies collection: reports funded by national institutes of health. Washington (DC): National Academies Press (US), 2011.
Kitano H. Biological robustness. Nat Rev Genet 2004, 5: 826–837.
CAS
PubMed
Article
Google Scholar
Derecki N, Privman E, Kipnis J. Rett syndrome and other autism spectrum disorders—brain diseases of immune malfunction? Mol Psychiatry 2010, 15: 355–363.
CAS
PubMed
PubMed Central
Article
Google Scholar