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The effect of trans-10,cis-12 conjugated linoleic acid on lipogenesis is tissue dependent in hamsters

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References

  1. Wang YW, Jones PJH (2004) Conjugated linoleic acid and obesity control: efficacy and mechanisms. Int J Obes 28:941–955

    Article  CAS  Google Scholar 

  2. Pariza MW, Park Y, Cook ME (2000) Mechanism of action of conjugated linoleic acid: evidence and speculation. Proc Soc Exp Biol Med 223:8–13

    Article  PubMed  CAS  Google Scholar 

  3. Kang K, Miyazaki M, Ntambi JM, Pariza MW (2004) Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. Biochem Biophys Res Commun 315:532–537

    Article  PubMed  CAS  Google Scholar 

  4. Azain MJ, Hausman DB, Sisk MB, Flatt WP, Jewell DE (2000) Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J Nutr 130:1548–1554

    PubMed  CAS  Google Scholar 

  5. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, Kim HJ, Tange T, Okuyama H, Kasai M, Ikemoto S, Ezaki O (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49:1534–1542

    Article  PubMed  CAS  Google Scholar 

  6. Clément L, Poirier H, Niot I, Bocher V, Guerre M-Millo, Krief S, Staels B, Besnard P (2002) Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res 43:1400–1409

    Article  PubMed  CAS  Google Scholar 

  7. Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125–1131

    Article  PubMed  CAS  Google Scholar 

  8. DeLany JP, Blohm F, Truett AA, Scimeca JA, West DB (1999) Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 276:R1172–R1179

    PubMed  CAS  Google Scholar 

  9. Hamura M, Yamatoya H, Kudo S (2001) Glycerides rich in conjugated linoleic acid (CLA) improve blood glucose control in diabetic C57BLKS-Leprdb/leprdb mice. J Oleo Sci 50:889–894

    CAS  Google Scholar 

  10. Martin JC, Grégoire S, Siess MH, Genby M, Chardigny JM, Berdeaux O, Juanéda P, Sébédio JL (2000) Effects of conjugated linoleic acid isomers on lipid-metabolizing enzymes in male rats. Lipids 35:91–98

    Article  PubMed  Google Scholar 

  11. Miner JL, Cederberg CA, Nielsen MK, Chen X, Baile CA (2001) Conjugated linoleic acid (CLA), body fat, and apoptosis. Obes Res 9:129–134

    Article  PubMed  CAS  Google Scholar 

  12. Terpstra AH, Beynen AC, Everts H, Kocsis S, Katan MB, Zock PL (2002) The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta. J Nutr 132:940–945

    PubMed  CAS  Google Scholar 

  13. Warren JM, Simon VA, Bartolini G, Erickson KL, Mackey BE, Kelley DS (2003) Trans-10,cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genes. Lipids 38:497–504

    Article  PubMed  CAS  Google Scholar 

  14. Belury MA, Kempa-Steczko A (1997) Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 32:199–204

    Article  PubMed  CAS  Google Scholar 

  15. West DB, DeLany JP, Camet P, Blohm FY, Truett AA, Scimeca J (1998) Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 275:R667–R672

    PubMed  CAS  Google Scholar 

  16. Takahashi Y, Kushiro M, Shinohara K, Ide T (2003) Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. Biochim Biophys Acta 1631:265–273

    PubMed  CAS  Google Scholar 

  17. Chin SF, Storkson JM, Albright KJ, Cook ME, Pariza MW (1994) Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J Nutr 124:2344–2349

    PubMed  CAS  Google Scholar 

  18. Sakono M, Miyanaga F, Kawahara S, Yamauchi K, Fukuda N, Watanabe K, Iwata T, Sugano M (1999) Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver. Lipids 34:997–1000

    Article  PubMed  CAS  Google Scholar 

  19. Stangl GI (2000) High dietary levels of conjugated linoleic acid mixture alter hepatic glycerophospholipid class profile and cholesterol-carrying serum lipoproteins of rats. J Nutr Biochem 11:184–191

    Article  PubMed  CAS  Google Scholar 

  20. Wang YM, Rahman SM, Nagao K, Han SY, Buang Y, Cha JY, Yanagita T (2003) Conjugated linoleic acid reduces hepatic microsomal triacylglycerol transfer protein activity and hepatic triacylglycerol mass in obese rats. J Oleo Sci 52:129–134

    CAS  Google Scholar 

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Acknowledgments

This study was supported by grants from the Ministerio de Ciencia y Tecnología (BFI2002-00273), the Government of País Vasco (Biogune, Programa Etortek) and University of País Vasco (00101.125-E-14788/2002 and 9/00101.125-15340/2003). V. Navarro is a recipient of a doctoral fellowship from the Ministerio de Educación y Ciencia.

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Authors and Affiliations

  1. Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain

    I. Churruca, A. Fernández-Quintela, A. Zabala, M. T. Macarulla, V. Navarro, V. M. Rodríguez, E. Simón & M. P. Portillo

  2. Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain

    F. Milagro

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  1. I. Churruca
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  2. A. Fernández-Quintela
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  3. A. Zabala
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  4. M. T. Macarulla
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  5. V. Navarro
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  6. V. M. Rodríguez
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  7. E. Simón
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  8. F. Milagro
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  9. M. P. Portillo
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Correspondence to M. P. Portillo.

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Churruca, I., Fernández-Quintela, A., Zabala, A. et al. The effect of trans-10,cis-12 conjugated linoleic acid on lipogenesis is tissue dependent in hamsters. Genes Nutr 2, 121–123 (2007). https://doi.org/10.1007/s12263-007-0031-8

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  • DOI: https://doi.org/10.1007/s12263-007-0031-8

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