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Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice

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Abstract

Berries and red fruits are important dietary sources of polyphenols [1]. In vitro and animal studies have demonstrated the bioavailability and the anti-proliferative and anticarcinogenic properties of these fruits or of their phenolic components [2, 3]. Consumption of berries may contribute to the reduction of colon cancer by mechanisms not yet understood. Gene expression analysis using microarrays allows for a more comprehensive study of the possible molecular mechanisms by which food or food components may prevent certain cancers of the gastrointestinal tract [4]. The aim of this research is to investigate the anti-proliferative effects of a polyphenol-rich berry juice on a human model of colon cancer cells and its association to transcriptional changes in relation to colon cancer.

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Acknowledgments

This research was funded by the Fundación Séneca, Murcia, Spain (PB/18/FS/02; 00490/PPC/04) and by the CICYT, Spain (AGL2003-02195; AGL2004-03989).

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Authors and Affiliations

  1. Research Group on Quality, Safety and Bioactivity of Plant Foods, Food Science and Technology, CEBAS-CSIC, Campus de Espinardo, 30100, Murcia, Spain

    M. J. Bermúdez-Soto, M. Larrosa, J. C. Espín, F. A. Tomás-Barberan & M. T. García-Conesa

  2. Unidad de Genómica, Parque Científico de Madrid, Facultad Biología, Universidad Complutense Madrid, 28040, Madrid, Spain

    J. García-Cantalejo

Authors
  1. M. J. Bermúdez-Soto
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  2. M. Larrosa
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  3. J. García-Cantalejo
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  4. J. C. Espín
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  5. F. A. Tomás-Barberan
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  6. M. T. García-Conesa
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Corresponding author

Correspondence to M. T. García-Conesa.

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Bermúdez-Soto, M.J., Larrosa, M., García-Cantalejo, J. et al. Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice. Genes Nutr 2, 111–113 (2007). https://doi.org/10.1007/s12263-007-0026-5

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  • DOI: https://doi.org/10.1007/s12263-007-0026-5

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