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Hepcidin: a New Serial Biomarker for Iron Deficiency Anemia in Bariatric Surgery

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Abstract

Iron deficiency anemia (IDA) is one of the most common nutritional problems in patients with obesity and after bariatric surgery. While it can be reduced with diet and oral supplementation, a subset of patients is refractory to these measures. Several factors have been implicated including high hepcidin levels reducing the release of absorbed iron into the circulation. We found 6 papers studying hepcidin levels before and after bariatric surgery. Patients with obesity have higher hepcidin and other inflammatory markers. Five out of six studies reported significant falls in hepcidin levels after bariatric surgery. This was accompanied by an improvement in the RBC morphology indices in restrictive surgeries. However, the fall in hepcidin is not uniform and may be a contributing factor for refractory IDA.

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  1. Belle Vue Clinic, Kolkata, India

    Sarfaraz J. Baig & Pallawi Priya

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Author 1 conceived the idea for the topic and initiated the research. Authors 1 and 2 wrote the manuscript. Both authors participated in the discussions on the topic. Both authors have seen the final version and approve of it.

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Baig, S.J., Priya, P. Hepcidin: a New Serial Biomarker for Iron Deficiency Anemia in Bariatric Surgery. Indian J Surg 85, 1035–1043 (2023). https://doi.org/10.1007/s12262-023-03690-7

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