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The Role of Serum Apelin Levels in Peripheral Artery Disease

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Abstract

Apelin is a bioactive mediator released by adipose tissue that can be involved in energy metabolism events and coronary artery disease. This study aims to investigate the role of serum apelin levels in patients with peripheral artery disease (PAD). The present observational case–control study consisted of 100 subjects (50 angiographically proven PAD patients and 50 healthy controls). Serum apelin and apelin receptor (APJ) levels were measured with blood samples. Clinical and laboratory findings were obtained from the hospital database system. The association between serum apelin levels, and PAD was investigated. The number of smokers and subjects with hypertension, coronary artery disease and diabetes mellitus was higher in the PAD group than in the control group (P < 0.05). Mean serum apelin levels were lower in the peripheral artery group than in the control group (mean: 13.94, SD 4.34 vs. mean: 16.79, SD 4.2, P = 0.001). On the other hand, the mean APJ levels were higher in the control group (mean: 36.1, SD 19.1 vs. mean: 27.7, SD 13.1, P = 0.019). There was no statistically significant difference between the two groups (20 (41.6%) vs. 21 (42%), P = 973) regarding the obesity. Our findings revealed that hypertension, smoking and diabetes mellitus rates were higher among patients with PAD. In fact, the lower apelin levels and higher APJ levels were risk factors associated with PAD; the obesity was not related with development of PAD.

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References

  1. Fowkes FG, Rudan D, Rudan I et al (2013) Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet 382:1329–1340

    Article  PubMed  Google Scholar 

  2. Kullo IJ, Rooke TW (2016) Peripheral artery disease. N Engl J Med 374:861–871

    Article  CAS  PubMed  Google Scholar 

  3. American Diabetes Association (2003) Peripheral arterial disease in people with diabetes. Diabetes Care 26:3333–3341

    Article  Google Scholar 

  4. Alzahrani HA, Wang D, Bakhotmah BA, Hu FB (2014) Risk factors for peripheral artery disease among patients with diabetes in Saudi Arabia. Vasc Med 19(2):103–111

    Article  PubMed  Google Scholar 

  5. Japp AG, Cruden NL, Barnes G, van Gemeren N, Mathews J, Adamson J et al (2010) Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. Circulation 121:1818–1827

    Article  CAS  PubMed  Google Scholar 

  6. Maguire JJ, Kleinz MJ, Pitkin SL, Davenport AP (2009) [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Hypertension 54:98–604

    Article  Google Scholar 

  7. Falcao-Pires I, Leite-Moreira AF (2005) Apelin: a novel neurohumoral modulator of the cardiovascular system: pathophysiologic importance and potential use as a therapeutic target. Rev Port Cardiol 24(10):1263–1276

    PubMed  Google Scholar 

  8. Szokodi I, Tavi P, Foldes G, Voutilainen-Myllyla S, Ilves M, Tokola H et al (2002) Apelin, the novel endogenous ligand of the orphan receptor APJ. regulates cardiac contractility. Circ Res 91(5):434–440

    Article  CAS  PubMed  Google Scholar 

  9. Kadoglou NP, Lampropoulos S, Kapelouzou A, Gkontopoulos A, Theofilogiannakos EK, Fotiadis G, Kottas G (2010) Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease–KOZANI STUDY. Transl Res 155(5):238–246

    Article  CAS  PubMed  Google Scholar 

  10. (2017) 2017 ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases. Developed in collaboration with the European Society for Vascular Surgery (ESVS). Eur Heart J 39(9):763–816

  11. Criqui MH, Aboyans V (2015) Epidemiology of peripheral artery disease. Circ Res 116:1509–1526

    Article  CAS  PubMed  Google Scholar 

  12. Bauersachs R, Zeymer U, Brière JB, Marre C, Bowrin K, Huelsebeck M (2019) Burden of coronary artery disease and peripheral artery disease: a literature review. Cardiovasc Ther 2019;26:8295054

  13. Aguilar-Salinas CA, García EG, Robles L, Riaño D, Ruiz-Gomez DG, García-Ulloa AC et al (2008) High adiponectin concentrations are associated with the metabolically healthy obese phenotype. J Clin Endocrinol Metab 93(10):4075–4079

    Article  CAS  PubMed  Google Scholar 

  14. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH (2009) The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 25(9):88

    Article  Google Scholar 

  15. Bełtowski J (2006) Apelin and visfatin: unique “beneficial” adipokines upregulated in obesity? Med Sci Monit 12(6):RA12-119

    Google Scholar 

  16. Yue P, Jin H, Xu S, Aillaud M, Deng AC, Azuma J et al (2011) Apelin decreases lipolysis via Gq. Gi. and AMPK-dependent mechanisms. Endocrinology 152:59–68

    Article  CAS  PubMed  Google Scholar 

  17. Than A, Zhang X, Leow MK, Poh CL, Chong SK, Chen P (2014) Apelin attenuates oxidative stress in human adipocytes. J Biol Chem 289(6):3763–3774

    Article  CAS  PubMed  Google Scholar 

  18. Lv S, Feng Y, Jiang Q, Lv X, Yang Y (2021) Relationship between Apelin/APJ signaling, oxidative stress, and diseases. Oxidative Med Cell Longev 2021:1–7

    Google Scholar 

  19. Akcilar R, Yumun G, Bayat Z, Donbaloglu O, Erselcan K, Ece E, Kokdasgil H, Genc O (2015) Characterization of the apelin -1860T>C polymorphism in Turkish coronary artery disease patients and healthy individuals. Int J Physiol Pathophysiol Pharmacol 7(4):165–171

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Li Z, Bai Y, Hu J (2008) Reduced apelin levels in stable angina. Intern Med 47(22):1951–1955

    Article  PubMed  Google Scholar 

  21. Chen T, Wu B, Lin R (2017) Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies. Oncotarget 8(34):57345–57355

    Article  PubMed  PubMed Central  Google Scholar 

  22. Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O’Dowd BF (2005) Modification of the terminal residue ofapelin-13 antagonizes its hypotensive action. Endocrinology. 146(1):231–236

    Article  CAS  PubMed  Google Scholar 

  23. Kaplan M, Yavuz F, Kaplan GI, Bursa N, Vuruşkan E, Sucu M (2021) Elabela as a novel marker: well-correlated with WIfI amputation risk score in lower extremity arterial disease patients. Anatol J Cardiol 25(5):330–337

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Butruille L, Drougard A, Knauf A, Moitrot E, Valet P, Storme L, Deruelle P, Lesage J (2013) The apelinergic system: sexual dimorphism and tissue-specific modulations by obesity and insulin resistance in female mice. Peptides 46(1):94–101

    Article  CAS  PubMed  Google Scholar 

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Funding

This study was supported by the Namık Kemal University Research Fund (Project no: NKUBAP.02.GA.18.169).

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Tekirdag Dr. Ismail Fehmi Cumalioglu City Hospital, Tekirdag, Turkey

    Gündüz Yümün

  2. Department of Cardiovascular Surgery, Tekirdag Namik Kemal University Medical Faculty Hospital, 59300, Tekirdag, Turkey

    Selami Gürkan

  3. Department of Biochemistry, Tekirdag Namik Kemal University, Medical Faculty, Tekirdag, Turkey

    Ahsen Yilmaz & Savaş Güzel

Authors
  1. Gündüz Yümün
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  2. Selami Gürkan
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  3. Ahsen Yilmaz
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  4. Savaş Güzel
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Correspondence to Gündüz Yümün.

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Yümün, G., Gürkan, S., Yilmaz, A. et al. The Role of Serum Apelin Levels in Peripheral Artery Disease. Indian J Surg 85 (Suppl 1), 214–218 (2023). https://doi.org/10.1007/s12262-022-03370-y

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  • DOI: https://doi.org/10.1007/s12262-022-03370-y

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