Abstract
Sump syndrome is a rare complication of a side to side choledochoduodenostomy (CDD). After the introduction of endoscopic retrograde cholangiopancreatography (ERCP) in 1968 Kozarek (Gastroenterol Hepatol (N Y) 13(10):620-622, 2017), choledochoduodenostomy and its complications are seldom seen. The diagnosis of sump syndrome is further befogged by the lack of characteristic clinical or laboratory findings, the inability of the patient to provide medical records of their CDD, and the fact that sump syndrome only presents decades after a CDD. In this article, we will present a case of a 39-year-old female patient who presented as a case of ascending cholangitis with an initially unknown past surgical history. A detailed medical history was thoroughly taken, and her previous medical reports were presented after which an ERCP was done with extraction of debris was preformed. In a time where choledochoduodenostomy is rarely being chosen as a choice of treatment and its complications are infrequently encountered, this case serves as a reminder that even in the ERCP era, complications of choledochoduodenostomy should still be well understood.
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Case Presentation
This is a case of a 39-year-old female who presented to our emergency department in Mubarak Al Kabeer Hospital with abdominal pain, mainly in the right upper quadrant with nausea for two days. She also had bouts of repeated vomiting, jaundice, and pruritus. On admission her vitals were a heart rate of 78 beats per minute (BPM), a temperature of 37 °C, and a blood pressure of 130/80 mmHg. Her abdomen was tender in the right upper quadrant and epigastric regions, and she had guarding in the former.
Her surgical history was significant for an open cholecystectomy (most likely due to symptomatic cholelithiasis) when she was 14 years of age. She underwent three further procedures which were unknown at the time of presentation but after obtaining her medical reports; it was revealed that she had undergone an endoscopic retrograde cholangiopancreatography (ERCP), a common bile duct (CBD) exploration with an intra-operative cholangiogram (IOC) and a choledochoduodenostomy (for a CBD stone that could not have been removed by ERCP).
Initial laboratory investigations showed a white blood cell count (WBC) of 16.16 k/cmm, a total bilirubin of 38.5 mmol/L, direct bilirubin of 21, alkaline phosphatase of 298 IU/L, gamma glutamyl transpeptidase (GGT) of 564 U/L, aspartate transaminase/alanine transaminase (AST/ALT) of 150/107 U/L, and an amylase of 101 U/L. Initial imaging studies of an abdominal X-ray was unremarkable, abdominal ultrasound revealed intrahepatic dilatation of 1 cm, pneumobilia, and a normal CBD diameter. Computed tomography (CT) scan of the abdomen and pelvis with IV contrast revealed a large duodenal diverticulum in the second part of the duodenum causing a mass effect on the CBD and significant intra-hepatic dilatation, and the picture was consistent with ascending cholangitis.
The patient was started on meropenem for cholangitis, intravenous (IV) fluids, paracetamol, and tramadol (both IV) for controlling her abdominal pain. Within one day of her hospital admission, her clinical status worsened with a temperature of 38.5 °C and a heart rate of 120BPM, and her blood pressure was 90/60. She had a rise in her WBC (to 19.3 k/ccm), total bilirubin of 94.7, direct bilirubin of 65, alkaline phosphatase of 232, GGT of 421, and an ALT/AST of 80/75. She underwent a percutaneous transhepatic biliary drainage (PTBD) (right access), and she was admitted to the intensive care unit (ICU).
The patient’s clinical status improved after the placement of the PTBD tube. She was discharged from the ICU. Her vitals were normal with a normal heart rate, blood pressure, and temperature. A magnetic resonance cholangiopancreatography (MRCP) was done on her third hospital day and revealed S/P choledochoduodenostomy with dilated biliary system and a beaded like appearance of the dilated biliary radicles. Her clinical status continued to improve with WBC counts and bilirubin counts trending down. The PTBD was draining around 400–800 ml of bile per day. On her sixth admission day, she was able to get a report of her previous surgeries. After confirming that she had undergone a choledochoduodenostomy, an ERCP was done. The findings revealed 3 openings in the second part of the duodenum, feculent material was seen from what seemed to be a duodenal diverticulum which was cleared, the CBD was cannulated and she had extremely dilated intrahepatic radicles, a large filling defect was seen in the distal CBD and a sphincterotomy was done. The third opening was the choledochoduodenostomy anastomosis. After the ERCP, her bilirubin levels continued to trend down. Her ERCP was repeated with the presence of a hepatobiliary surgeon and a senior gastroenterologist present. The CBD was filled with debris; the debris was ascending all the way up to the intrahepatic radicles. The debris was cleared using a Dormia basket.
After the second ERCP, her WBC, bilirubin, and AST/ALT levels were back to normal levels. Her PTBD was clamped, and her investigations remained unchanged. Her PTBD tube was removed, and she was discharged with a diagnosis of sump syndrome complicated by ascending cholangitis.
Discussion
Sump syndrome has been managed as early as 1976 [1] with prevalence of 0–15.7% after a side-to-side choledochoduodenostomy, which was common in the pre-ERCP period [2] [3], making sump syndrome a rare complication of side to side choledochoduodenostomy [4]. Anatomically, there will be a potential reservoir or “sump” between the anastomosis and the ampulla of Vater. Patients presenting with ascending cholangitis decades after a choledochoduodenostomy should raise the suspicion of sump syndrome with cholangitis developing due to build up of debris, stones, or infected bile and a possible defect in the ampulla of Vater [5]. ERCP has almost completely replaced CDD for addressing obstructive CBD disease [2] [6], and so complications of CDD including sump syndrome are now very rarely seen. If ERCP fails, laparoscopic/open CBD exploration are the first line surgical procedures performed [7]. If drainage is not possible, choledochojejunostomy and hepaticojejunostomy are usually the procedures of choice making CDD and in effect sump syndrome very rarely seen. Furthermore, as seen with our patient, medical records may be difficult to obtain or lost, and patients may not full understand what procedure they have undergone making it more difficult to diagnose sump syndrome. Even radiological images may miss a choledochoduodenostomy in the absence of a proper surgical history.
When sump syndrome is suspected, ERCP is the first-line treatment [8], if sump syndrome recurs, a repeat ERCP is performed with good results; surgical intervention is not recommended considering the good results achieved by the ERCP [9]. In some instances, ERCP may be difficult such as cases who have undergone a Roux-en-Y gastric bypass [10], or in cases where ERCP fails, for those circumstances, a hepaticojejunostomy or choledochojejunostomy is the treatment of choice.
Conclusion
In the current practice, little is known about sump syndrome due to the scarcity of its presentation; however, it is important to include it in the differential diagnosis of cholangitis. After the introduction of ERCP, CDD is now rarely performed, but patients may present decades later, so it is important for the younger generation to understand its complications.
References
Caroli-Bosc FX, Demarquay JF, Peten EP, Dumas R, Bourgeon A, Rampal P, Delmont JP (2000) Endoscopic management of sump syndrome after choledochoduodenostomy: retrospective analysis of 30 cases. Gastrointest Endosc 51:180–183
Abraham H, Thomas S, Srivastava A (2017) Sump syndrome: a rare long-term complication of choledochoduodenostomy. Case Rep Gastroenterol 11(2):428–433
Suliman MS, Singh MM, Zaheer K et al (2019) Is it really SUMP syndrome? A Case Report. Cureus 11(10):e5837
Zeuge U, Fehr M, Meyenberger C, Sulz M (2014) C: Mind the sump! - diagnostic challenge of a rare complication of choledochoduodenostomy. Case Rep Gastroenterol 8:358–363
Hawes DR, Pelsang RE, Janda RC, Lu CC (1992) Imaging of the biliary sump syndrome. Am J Roentgenol 158:315–319
TStefanini P, Carboni M, Patrassi N, et al (1974) Transduodenal sphincteroplasty: its use in the treatment of lithiasis and benign obstruction of the common duct. Am J Surg 128:672–677
Marc Zerey MD, Stephen Haggerty MD, William Richardson MD, Byron Santos MD, Robert Fanelli MD, L. Michael Brunt MD, Dimitrios Stefanidis MD (2017) Clinical spotlight review: laparoscopic common bile duct exploration - SAGES; sages website
Baker AR, Neoptolemos JP, Carr-Locke DL, Fossard DP (1985) Sump syndrome following choledochoduodenostomy and its endoscopic treatment. Br J Surg 72:433–435
Mavrogiannis C, Liatsos C, Romanos A, Goulas S, Dourakis S, Nakos A, Karvountzis G (1999) Sump syndrome: endoscopic treatment and late recurrence. Am J Gastroenterol 94:972–975
Alqahtani MS, Alshammary SA, Alqahtani EM, Bojal SA, Alaidh A, Osian G (2016) Hepaticojejunostomy for the management of sump syndrome arising from choledochoduodenostomy in a patient who underwent bariatric Roux-en-Y gastric bypass: a case report. Int J Surg Case Rep 21:36–40
Kozarek RA (2017) The past, present, and future of endoscopic retrograde cholangiopancreatography. Gastroenterol Hepatol (N Y) 13(10):620–622
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare no competing interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Alnouri, H.H., Alyatama, K. The Challenges of Sump Syndrome: a Case Report and Literature Review. Indian J Surg 84, 1093–1095 (2022). https://doi.org/10.1007/s12262-021-03197-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12262-021-03197-z