Abstract
Pancreatic cancer is an important public health problem, although infrequent but with an exceptionally high mortality rate worldwide. Given that the majority of cancers occur in association with smoking, diabetes, pancreatitis, genetic factors, and others and with a growing population worldwide in mind, more cases would be expected in the near future giving further impetus to investigating prevention and treatment strategies to this international issue. The representative data on epidemiology of carcinoma of pancreas in India and Nepal are very poor. While there are many questions to be resolved, it is apparent that many facets of pancreatic cancer are becoming increasingly understood, and prospects for prevention are becoming apparent. Hence, screening research, recommendations, and implementation is an obvious priority. Although previous studies have contributed to the knowledge of carcinoma of pancreas epidemiology, such association needs to be further verified with proper epidemiological work. A new and global approach to the study of carcinoma of pancreas epidemiology is required if the disease prevention and treatment strategies are to be adequately directed and supported in the coming years. The collection and analysis of epidemiologic carcinoma of pancreas data will play a critical role in guiding future disease prevention strategies and optimizing patient management.
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References
Parkin DM, Bray F, Ferlay J, Pisani P (2002) Global cancer statistics. CA Cancer J Clin 55(2):74–108
Raimondi S, Maisonneuve P, Lowenfels AB (2009) Epidemiology of pancreatic cancer: an overview. Nat Rev Gastroenterol Hepatol 6(12):699–708
SEER Cancer Statistics Factsheets: Pancreas Cancer. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/statfacts/html/pancreas.html
Dhir V, Mohandas K (1999) Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas. Indian J Gastroenterol 18(1):24–28
Calhoun ES, Kern SE (2008) Molecular genetics of pancreatic cancer. In: Lowy AM, Leach SD, Philip PA (eds) Pancreatic cancer. Springer, New York
Hart AR, Kennedy H, Harvey I (2008) Pancreatic cancer: a review of the evidence on causation. Clin Gastroenterol Hepatol 6(3):275–82
Lowenfels AB, Maisonneuve P, DiMagno EP et al (1997) Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst 89(6):442–6
Giardiello FM, Brensinger JD, Tersmette AC et al (2000) Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119(6):1447–53
Yoon KH, Lee JH, Kim JW et al (2006) Epidemic obesity and type 2 diabetes in Asia. Lancet 368(9548):1681–8
Muniraj T, Chari ST (2012) Diabetes and pancreatic cancer. Minerva Gastroenterol Dietol 58(4):331–345
Huxley R, Ansary-Moghaddam A, Berrington de González A, Barzi F, Woodward M (2005) Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 92(11):2076–83
Li D (2012) Diabetes and pancreatic cancer. Mol Carcinog 51(1):64–74
Howes N, Neoptolemos JP (2002) Risk of pancreatic ductal adenocarcinoma in chronic pancreatitis. Gut 51(6):765–76
Chari ST, Mohan V, Pitchumoni CS et al (1994) Risk of pancreatic carcinoma in tropical calcifying pancreatitis: an epidemiologic study. Pancreas 9(1):62–66
Rebours V, Boutron-Ruault MC, Schnee M et al (2008) Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. Am J Gastroenterol 103(1):111–9
Bansal P, Sonnenberg A (1995) Pancreatitis is a risk factor for pancreatic cancer. Gastroenterology 109(1):247–51
Iodice S, Gandini S, Maisonneuve P, Lowenfels AB (2008) Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg 393(4):535–45
Bosetti C, Lucenteforte E, Silverman DT et al (2012) Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-control Consortium (Panc4). Ann Oncol 23:1880–8
Boffetta P, Hecht S, Gray N, Gupta P, Straif K (2008) Smokeless tobacco and cancer. Lancet Oncol 9(7):667–75
Jang JH, Cotterchio M, Borgida A et al (2012) Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk. Carcinogenesis 33(4):818–27
Pandol SJ, Apte MV, Wilson JS et al (2012) The burning question: why is smoking a risk factor for pancreatic cancer? Pancreatology 12(4):344–9
Raimondi S, Maisonneuve P, Löhr J-M, Lowenfels AB (2007) Early onset pancreatic cancer: evidence of a major role for smoking and genetic factors. Cancer Epidemiol Biomarkers Prev 16(9):1894–7
Yadav D, Lowenfels AB (2013) The epidemiology of pancreatitis and pancreatic cancer. Gastroenterol 144(6):1252–1261
Kreiger N, Lacroix J, Sloan M (2001) Hormonal factors and pancreatic cancer in women. Ann Epidemiol 11(8):563–7
Silverman DT, Hoover RN, Brown LM et al (2003) Why do Black Americans have a higher risk of pancreatic cancer than White Americans? Epidemiology 14(1):45–54
Ye W, Lagergren J, Weiderpass E et al (2002) Alcohol abuse and the risk of pancreatic cancer. Gut 51:236–9
Jiao L, Silverman DT, Schairer C et al (2009) Alcohol use and risk of pancreatic cancer: the NIH-AARP Diet and Health Study. Am J Epidemiol 169(9):1043–51
Vrieling A, Verhage BAJ, van Duijnhoven FJB et al (2009) Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 124(8):1926–34
Ghorbani Z, Hekmatdoost A, Zinab HE et al (2015) Dietary food groups intake and cooking methods associations with pancreatic cancer: a case-control study. Indian J Gastroenterol 34(3):225–32
Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J, Albanes D (2002) Prospective study of diet and pancreatic cancer in male smokers. Am J Epidemiol 155:783–92
Lee IM, Sesso HD, Oguma Y, Paffenbarger RS Jr (2003) Physical activity, bodyweight, and pancreatic cancer mortality. Br J Cancer 88:679–83
Bonifazi M, Gallus S, Bosetti C et al (2010) Aspirin use and pancreatic cancer risk. Eur J Cancer Prev 19:352–4
Streicher SA, Yu H, Lu L, Kidd MS, Risch HA (2014) Case-control study of aspirin use and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 23(7):1254–63. doi:10.1158/1055-9965.EPI-13-1284
Tan XL, Reid Lombardo KM, Bamlet WR et al (2011) Aspirin, nonsteroidal anti-inflammatory drugs, acetaminophen, and pancreatic cancer risk: a clinic-based case-control study. Cancer Prev Res 4:1835–41
Khurana V, Sheth A, Caldito G, Barkin JS (2007) Statins reduce the risk of pancreatic cancer in humans: a case-control study of half a million veterans. Pancreas 34(2):260–5
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Thapa, P. Epidemiology of Pancreatic and Periampullary Cancer. Indian J Surg 77, 358–361 (2015). https://doi.org/10.1007/s12262-015-1365-x
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DOI: https://doi.org/10.1007/s12262-015-1365-x