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An Overview on Taxol Production Technology and Its Applications as Anticancer Agent

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An Erratum to this article was published on 24 December 2022

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Abstract

Cancer is undeniably a major health risk factor that is growing rapidly globally despite promising medicinal and pharmaceutical development. Treatment of cancer remains an issue due to financial constrains in most of the developing countries. The majority of today’s medicines are derived from medicinal plants, as we all know. Taxol is such a plant-based chemotherapeutic agent which has blown the anticancer research field. The extinction of Taxus spp., which is the main natural source of taxol synthesis, required the development of novel alternative approaches in the oncology field. Many novel discoveries have been in trend in which endophytic microbial fermentation process is more focused as this area is cost-efficacious, less time consumable, and eco-friendly. Endophytes are one of another alternative approach for the taxol production, preserving the natural resources of Taxus plants worldwide. Endophytic microorganisms can be exploited in the taxol industry because most of the endophytic microbes have yet to be explored for the eco-friendly and economical production of this wonder drug. The aim of this review article is to cover everything from the discovery of taxol through the development of new natural resource-based biotechnology techniques. Furthermore, the current review has emphasised the use of taxol in fields other than anti-cancer properties, as well as pointing to some future opportunities.

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Acknowledgements

The authors would like to thank Prof. P. K. Khosla, Hon’ble Chancellor, Shoolini University of Biotechnology and Management Sciences, Solan and Foundation for Life Sciences and Business Management (FLSBM), Solan (H.P.)-India for providing financial support and necessary facilities.

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Authors and Affiliations

  1. Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India

    Aparajita Sharma, Aditya Banyal, Ishita Chanana, Saurabh Kulshrestha & Pradeep Kumar

  2. Department of Biological Engineering, College of Engineering, Konkuk University, Seoul, 05029, Korea

    Shashi Kant Bhatia

  3. School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India

    Anil Kumar

  4. Department of Biotechnology, Himachal Pradesh University, Summer Hill, Shimla, 171005, India

    Duni Chand

  5. Department of Environmental Engineering, Ajou University, Suwon, 16499, Korea

    Pradeep Kumar

Authors
  1. Aparajita Sharma
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  2. Shashi Kant Bhatia
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  3. Aditya Banyal
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  4. Ishita Chanana
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  5. Anil Kumar
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  6. Duni Chand
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  7. Saurabh Kulshrestha
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  8. Pradeep Kumar
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Contributions

Aparajita Sharma: Conceptualization, Data curation, Formal analysis, Writing-original draft, Writing-Review & editing, Validation; Shashi Kant Bhatia: Data curation, Formal analysis, Writing-Review & editing, Validation; Aditya Banyal: Data curation, Formal analysis, Validation; Ishita Chanana: Data curation, Formal analysis; Anil Kumar: Formal analysis, Data curation, Formal analysis, Validation; Duni Chand: Formal analysis, Data curation, Formal analysis; Saurabh Kulshrestha: Data curation, Formal analysis; Pradeep Kumar: Conceptualization, Data curation, Formal analysis, Writing-original draft, Writing-Review & editing, Validation.

Corresponding author

Correspondence to Pradeep Kumar.

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Sharma, A., Bhatia, S.K., Banyal, A. et al. An Overview on Taxol Production Technology and Its Applications as Anticancer Agent. Biotechnol Bioproc E 27, 706–728 (2022). https://doi.org/10.1007/s12257-022-0063-3

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  • DOI: https://doi.org/10.1007/s12257-022-0063-3

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