Abstract
A batch experiment was conducted to investigate the effect of 10-deacetylpaclitaxel (10-DAP) on the adsorption characteristics of paclitaxel in a two-component adsorption of paclitaxel and 10-DAP by varying the concentration of 10-DAP (1,000–3,000 ppm) and adsorption temperature (298–318 K). The maximum adsorbed amount and adsorption rate constant of paclitaxel decreased by 10.1–21.3% and 5.5–28.6% at 298 K, 6.0–20.4% and 5.8–28.4% at 308 K, and 6.2–17.7% and 7.5–29.0% at 318 K, respectively, compared with the single-component adsorption of paclitaxel (control). These results show that the decrease rate was higher as the concentration of 10-DAP increased. In addition, as the concentration of 10-DAP increased, the adsorption rate constant decreased at all the adsorption temperatures, indicating that 10-DAP inhibited the adsorption of paclitaxel. The intraparticle diffusion rates decreased by 2.6–6.6% (10-DAP 1,000 ppm), 3.6–8.2% (10-DAP 2,000 ppm), and 8.0–10.0% (10-DAP 3,000 ppm) compared with the control. The thermodynamic study showed that the two-component adsorption was physical, endothermic, irreversible, and nonspontaneous.
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References
Kang, H. J. and J. H. Kim (2020) Removal of residual toluene and methyl tertiary butyl ether from amorphous paclitaxel by simple rotary evaporation with alcohol pretreatment. Biotechnol. Bioprocess Eng. 25: 86–93.
Seca, A. M. L. and D. C. G. A. Pinto (2018) Plant secondary metabolites as anticancer agents: Successes in clinical trials and therapeutic application. Int. J. Mol. Sci. 19: 263.
Kang, H. J. and J. H. Kim (2019) Removal of residual chloroform from amorphous paclitaxel pretreated by alcohol. Korean J. Chem. Eng. 36: 1965–1970.
Pyo, S. H., H. J. Choi, and B. H. Han (2006) Large-scale purification of 13-dehydroxybaccatin III and 10-deacetylpaclitaxel, semi-synthetic precursors of paclitaxel, from cell cultures of Taxus chinensis. J. Chromatogr. A. 1123: 15–21.
Seo, H. W. and J. H. Kim (2019) Ultrasound-assisted fractional precipitation of paclitaxel from Taxus chinensis cell cultures. Process Biochem. 87: 238–243.
Choi, H. K., J. S. Son, G. H. Na, S. S. Hong, Y. S. Park, and J. Y. Song (2002) Mass production of paclitaxel by plant cell culture. Korean J. Plant Biotechnol. 29: 59–62.
Yoo, K. W. and J. H. Kim (2018) Kinetics and mechanism of ultrasound-assisted extraction of paclitaxel from Taxus chinensis. Biotechnol. Bioprocess Eng. 23: 532–540.
Lee, C. G. and J. H. Kim (2016) Separation behavior of paclitaxel and its semi-synthetic precursor 10-deacetylpaclitaxel from plant cell cultures. Korean Chem. Eng. Res. 54: 89–93.
Lim, Y. S. and J. H. Kim (2017) Isotherm, kinetic and thermodynamic studies on the adsorption of 13-dehydroxybaccatin III from Taxus chinensis onto Sylopute. J. Chem. Thermodyn. 115: 261–268.
Kim, J. H., I. S. Kang, H. K. Choi, S. S. Hong, and H. S. Lee (2002) A novel prepurification for paclitaxel from plant cell cultures. Process Biochem. 37: 679–682.
Pyo, S. H., H. B. Park, B. K. Song, B. H. Han, and J. H. Kim (2004) A large-scale purification of paclitaxel from cell cultures of Taxus chinensis. Process Biochem. 39: 1985–1991.
Pyo, S. H., B. K. Song, C. H. Ju, B. H. Han, and H. J. Choi (2005) Effects of absorbent treatment on the purification of paclitaxel from cell cultures of Taxus chinensis and yew tree. Process Biochem. 40: 1113–1117.
Lee, J. Y. and J. H. Kim (2011) Development and optimization of a novel simultaneous microwave-assisted extraction and adsorbent treatment process for separation and recovery of paclitaxel from plant cell cultures. Sep. Purif. Technol. 80: 240–245.
Oh, H. J., H. R. Jang, K. Y. Jung, and J. H. Kim (2013) Evaluation of surface area of mesoporous silica adsorbents for separation and purification of paclitaxel. Microporous Mesoporous Mater. 180: 109–113.
Kang, H. J. and J. H. Kim (2019) Adsorption kinetics, mechanism, isotherm, and thermodynamic analysis of paclitaxel from extracts of Taxus chinensis cell cultures onto Sylopute. Biotechnol. Bioprocess Eng. 24: 513–521.
Lee, S. H. and J. H. Kim (2019) Kinetic and thermodynamic characteristics of microwave-assisted extraction for the recovery of paclitaxel from Taxus chinensis. Process Biochem. 76: 187–193.
Kim, H. S. and J. H. Kim (2017) Kinetics and thermodynamics of microwave-assisted drying of paclitaxel for removal of residual methylene chloride. Process Biochem. 56: 163–170.
Maneechakr, P. and S. Karnjanakom (2017) Adsorption behaviour of Fe(II) and Cr(VI) on activated carbon: Surface chemistry, isotherm, kinetic and thermodynamic studies. J. Chem. Thermodyn. 106: 104–112.
Cho, D. N. and J. H. Kim (2020) Isotherm, kinetic and thermodynamic characteristics for adsorption of acenaphthene onto Sylopute. Korean Chem. Eng. Res. 58: 127–134.
Kang, D. Y. and J. H. Kim (2021) Ultrasonic cavitation bubble- and gas bubble-assisted adsorption of paclitaxel from Taxus chinensis onto Sylopute. Korean J. Chem. Eng. 38: 2286–2293.
Wu, F. C., R. L. Tseng, and R. S. Juang (2005) Comparisons of porous and adsorption properties of carbons activated by steam and KOH. J. Colloid Interface Sci. 283: 49–56.
Marczewski, A. W., M. Seczkowska, A. Derylo-Marczewska, and M. Blachnio (2016) Adsorption equilibrium and kinetics of selected phenoxyacid pesticides on activated carbon: effect of temperature. Adsorption. 22: 777–790.
Kim, Y. S. and J. H. Kim (2019) Isotherm, kinetic and thermodynamic studies on the adsorption of paclitaxel onto Sylopute. J. Chem. Thermodyn. 130: 104–113.
Shin, H. S. and J. H. Kim (2016) Isotherm, kinetic and thermodynamic characteristics of adsorption of paclitaxel onto Diaion HP-20. Process Biochem. 51: 917–924.
Boparai, H. K., M. Joseph, and D. M. O’Carroll (2011) Kinetics and thermodynamics of cadmium ion removal by adsorption onto nano zerovalent iron particles. J. Hazard. Mater. 186: 458–465.
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This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2021R1A2C1003186).
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Kang, DY., Kim, JH. Two-component Adsorption Characteristics of Paclitaxel and 10-deacetylpaclitaxel from Taxus chinensis onto Sylopute. Biotechnol Bioproc E 27, 145–155 (2022). https://doi.org/10.1007/s12257-021-0123-0
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DOI: https://doi.org/10.1007/s12257-021-0123-0