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In this issue of the Magazine of European Medical Oncology (MEMO), we provide a series of articles summarizing data and discussing illustrative patient cases concerning the management of adverse events across oncological indications and affected organ systems.
Drs. Scheiner and Pinter present a case of immune-related hepatitis and dermatitis in a patient with hepatocellular carcinoma treated with nivolumab [1]. Based on this case report, they discuss the incidence and time of onset of immune checkpoint inhibitor (ICI)-associated autoimmune hepatitis, the choice of immune-modulating medication, and the implications for patient outcome.
Dr. Wass et al. discuss ICI-associated pneumonitis, a relatively rare immune-related adverse event, which may however substantially endanger patient’s quality of life and survival prognosis [2]. The authors provide a concise review on the topic and present a case report that illustrates the clinical management of ICI-associated pneumonitis.
Dr. Bergler-Klein reviews contemporary guidelines for prevention and treatment of cardiotoxicity from oncological therapies [3]. The article provides an overview of recommended strategies for baseline individual risk assessment, cardiovascular surveillance, echocardiography and blood-based biomarkers. In addition, a case vignette is discussed.
Finally, Drs. Wolf and Scherer summarize aspects on the clinical management of endocrine immune-related adverse events including thyroiditis, hypophysitis, diabetes mellitus, primary adrenal insufficiency and primary hypoparathyroidism [4].
Overall, the current collection of articles provides insights and clinically relevant information on adverse event management in oncological practice that may help to improve patient outcomes.
References
Pinter M, Scheiner B. Immune-related hepatitis in a patient with hepatocellular carcinoma treated with nivolumab. memo. 2021; https://doi.org/10.1007/s12254-021-00747-9.
Wass R, Lang D, Horner A, Lamprecht B. Checkpoint inhibitor pneumonitis: short review on literature and case report. memo. 2021; https://doi.org/10.1007/s12254-021-00756-8.
Bergler-Klein J. Cardiotoxicity—current recommendations of prevention and treatment. memo. 2021; https://doi.org/10.1007/s12254-021-00766-6.
Wolf P, Scherer T. Clinical challenges in the management of endocrine side effects of immune-oncological therapies. memo. 2021; https://doi.org/10.1007/s12254-021-00773-7.
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M. Preusser has received honoraria for lectures, consultation or advisory board participation from the following for-profit companies: Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, Astra Zeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome, Tocagen, Adastra, Gan & Lee Pharmaceuticals.
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Preusser, M. Toxicity management in severe and refractory cases—what we have learned. memo 15, 4 (2022). https://doi.org/10.1007/s12254-021-00788-0
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DOI: https://doi.org/10.1007/s12254-021-00788-0