The purpose of this observational study was to determine the prevalence of comorbid conditions in cancer patients with solid tumours selected for specific treatment at 12 divisions of medical oncology in Austria. Data from 1137 patients were collected using a standardized questionnaire; of these, 1036 datasets were evaluable for further analysis. Data were prospectively collected from patients during an in- or outpatient hospital visit over a 4-month period in 2011. Of these patients 42% had gastrointestinal cancer, 31% had breast cancer, 9% lung cancer and the remaining had urogenital cancer, sarcoma or other types of rare cancers. Around two-thirds of patients had metastatic disease (59%), confined to a single organ site in 55% of patients. A high proportion of patients had a good performance status (Eastern Cooperative Oncology Group [ECOG] 0, 1: 82%). Comorbid conditions were classified according to the Charlson scheme score and were present in 86% of patients with a median age of 64 years. The predominant conditions were cardiovascular diseases (57%), metabolic diseases (44%), endocrinological diseases (30%), gastrointestinal diseases (26%), neurological (23%) and respiratory diseases (23%). As has been reported by others we found a clear association between number of comorbid conditions and age. While 60% of the whole population had at least 2 comorbidities, most patients of the elderly population (89%) had more than three comorbidities. The high proportion of patients with comorbidities and accompanying medication represents a substantial challenge for medical oncologists in selecting the optimal cancer-specific treatment especially in the era of novel targeted and immunotherapies. Comorbid conditions and accompanying comedications require special precautions concerning potential interactions and unexpected adverse reactions from prescribed tumour-specific treatment.
In an age-adjusted view the overall cancer incidence and cancer mortality rates have declined slightly over the past decades. However, cancer incidence increases with age and due to the demographic changes with a growing older population the prevalence of cancer accumulates [1, 2]. In western countries more than 60% of newly diagnosed cancer patients are older than 65 years . Cancer treatment strategies aim to either maximise survival and/or to relieve cancer-associated symptoms limited by risks of treatment-related side effects. In elderly patients the achievements of modern oncology treatments seem to be of less impact on survival than in younger patients indicating challenging aspects concerning the risk–benefit ratio . Besides others, one major drawback may be the higher probability of comorbidity incidence in the aged population . More than half of all cancer patients older than 50 years had at least one comorbidity and it was shown that with higher age the number of comorbidities increases . Roger et al. reported that both cardiovascular disease and cancer are more prevalent with increasing age  with 38% of cancer patients suffering from hypertension . The negative prognostic impact of comorbid conditions in cancer patients has been shown in numerous reports [9, 10] and may be the result of an inadequate individually unadjusted anticancer treatment. In addition, a higher probability of treatment-related toxicity could also affect patients’ survival . Moreover, Satariano et al. reported on an independent effect of comorbidity on survival in breast cancer patients regardless of age, extent of disease and treatment . There is an increasing need for geriatric and social assessment in treatment planning in order to provide best treatment especially for elderly patients diagnosed with cancer.
The presence of comorbid conditions adds relevant complexity to the management of cancer patients by potential pharmacological interactions and unpredictable additional (new) toxicities induced by their accompanying comedications. At this time point we are lacking reliable data regarding this situation as patients with substantial comorbidities are generally excluded from participation in clinical cancer trials and vice versa cancer per se is an exclusion parameter for other trials. Consequently, anticancer drug development and their approval offer limited information relevant for daily routine treatment decisions. Therefore we face an urgent need on additional data dealing with real world patient cohorts to adopt to a more balanced risk–benefit evaluation. This initiative by the Austrian Society of Hematology and Oncology aims to illustrate the magnitude and impact of concomitant conditions in daily practice on a large cohort managed in daily routine.
Materials and methods
Study population and material
This hospital-based registry included cancer patients with solid tumours requiring systemic treatment admitted to 12 medical oncology departments in Austria. During a 4-month period in 2011 and based on predefined time spans, i.e. 5–10 working days, all patients admitted for treatment regardless of tumour stage were eligible and included in the study after written informed consent had been obtained. Information was gathered by means of a multi-item questionnaire including patients’ demographic and clinical characteristics, current treatment intention, indication of the Eastern Cooperative Oncology Group (ECOG) performance status and comorbid condition classified according to the Charlson score . Data were collected by treating physicians. The study was approved by the local ethical committee at the Medical University Graz.
In all, 1036 evaluable patients were included after informed consent was obtained: 56% were female and 44% were male, the majority of patients were older than 60 years of age (60%). Age distribution showed that 31% were between 60 and 70 years and 30% were older than 70 years of age. Five percent were younger than 40 and 34% were between 40 and 60 years of age at the time of inclusion. Median age was 64 years (range 21–92 years). Metastatic disease was the underlying cause for systemic treatment planned in the majority of patients (58%), fewer patients (39%) received neo/adjuvant or curative and only 3% of the patients a definitive treatment. The type of malignancy was distributed as follows: breast cancer in 31%, colorectal cancer in 25%, upper gastrointestinal (GI) cancer (including pancreas) in 17%, lung cancer in 9%, genitourinary cancer in 8%, and other (including sarcoma) in 9% of patients. In the presence of metastatic disease the predominant sites of metastatic involvement were liver, lung, bone and lymph nodes. Half of the patients presented with one metastatic site, 30% with two sites and 15% with multiple site involvement.
A total of 1137 questionnaires were collected in this 4‑month period and evaluable data on 1036 patients were obtained. Data on comorbid conditions were extracted from clinical records, letters, medical history and current medication (Table 1). The presence of at least one comorbid condition was documented in 86% of the patients. Similar proportions of patients had one (22%), two (23%), three (19%) or more than three (22%) comorbid conditions. The distribution of comorbidities in our population is shown in Table 2. A comparable distribution of comorbidities was reported when referring to the different tumour entities with the exception of lung cancer patients, who were more likely to have a higher rate of comorbidities. Only 5% of these patients had no, 38% had 1 or 2 and the remaining 57% had at least 3 comorbid conditions. There was a clear association between the number of comorbidities and the age of the patients (these differences were statistically significant, chi-squared test p < 0.001, Fig. 1). In our patient population cardiovascular diseases (57%) and metabolic diseases (44%) were predominantly seen, followed by endocrine diseases (30%). Among the patients with cardiovascular diseases 44% had hypertension, gastrointestinal (26%), neurological (23%) and diseases of the respiratory tract (23%) and renal impairment (13%).
A “low” comorbidity index (i.e. weighted Charlson index) was reported in 51%, “moderate” in 38%, “high” in 9%, and “very high” in 2% of patients. Metastases and second primary cancers were not counted as a separate comorbidity in this analysis, since the aim of the study was to assess comorbid conditions potentially interacting with tumour treatment . Otherwise, due to this fact more than two-thirds of patients would misleadingly have been allocated to the “very high” index group. Despite of the high proportion of patients with comorbid conditions (86%), the vast majority (82%) of the investigated population was in a good performance status (ECOG 0/1). We observed a significant association between increase in numbers of comorbid conditions and deterioration in performance status (chi-squared test p < 0.001, Fig. 2).
Concerning the cancer-specific treatment, 598 of the patients (58%) were allocated to receive palliative treatment, whereas for 409 patients (39%) the treatment was in adjuvant, neoadjuvant or curative intention. The remaining 29 patients (3%) were not clearly attributable to one of these treatment groups (e.g. definitive treatment with radiochemotherapy). The majority of patients treated (54%) were assigned to receive chemotherapy, regardless of the intention of treatment. Another 17% of the patients received a combination of chemo- and targeted therapy. Of the remaining patients, 14% were planned for targeted therapy alone and 17% for hormonal treatment. As indicated above, the majority of the patients (86%) allocated for treatment had at least one documented comorbid condition. Even patients with no comorbidity and with a good performance status, used medications other than those for cancer-specific treatment. We observed a significant correlation of number of medications prescribed in relation to the amount of comorbid conditions (chi-squared test p < 0.001, Fig. 3). Only 13% of the investigated population did not take any additional drug regardless of comorbidities and disease status. Patients who were assigned to get palliative tumour-specific treatment were more likely to have a higher number of comedications. There was a statistically significant increase in the number of medications prescribed in relation to the allocated cancer-specific treatment (chi-squared test p < 0.001; Fig. 4).
Our study demonstrates that a high proportion of patients had at least one comorbidity although in good performance status. Comorbid conditions were present in 86% of patients.
This study was performed in 2011, and since then an increasing number of different systemic treatments including a great number of novel tyrosine kinase inhibitors (TKIs) and diversity of immunotherapies were approved and are now used in patients with solid tumours. The awareness of comorbidities and comedications and their impact on prognosis of cancer patients along with a greater potential of drug interactions and increasing toxicity has therefore gained great importance. The performance status of the patient based on the comorbidities and their comedications has increasingly been taken into benefit–risk evaluation of different treatments and recently, practical management ASCO guidelines have been published for elderly patients  to improve patients’ management and selection.
Substantial increase of approved novel drugs in management of cancer patients offer new treatment options, but at the same time, a high rate of comorbidities and also older patients in the representative population in daily oncological practice is challenging a balanced treatment decision. The selection of drugs, dosing and safe prescription and administration are critical, considering the polypharmaceutical medication of the comorbid patients, particularly in the elderly. Others have already shown that comorbidities are correlated with an increased risk for toxicities, reduced treatment delivery and minor outcome when compared with a less comorbid patient cohort.
Profound knowledge on noncancer diseases is mandatory for medical oncologists, since comorbidities may exacerbate under anticancer treatment, e.g. diabetes (steroid-induced) or heart failure, coronary heart disease or other vascular diseases with life-threatening potential both due to worsening of pre-existing diseases or due to drug interaction (e.g. interaction with anticoagulation inducing bleeding). Recently, also the need for immunosuppressive drugs due to autoimmune diseases has come into focus, which became particularly important with the introduction of immune checkpoint inhibitors.
Our study performed on 1137 patients scheduled for cancer-specific treatment by using a standardized questionnaire exemplifies the magnitude of the clinical problem, demonstrating high prevalence of comorbid conditions with 83% of the patients having at least one comorbidity. Lung cancer patients had the highest prevalence, with 95% proven to have a concomitant comorbid condition. Furthermore, in the cohort of patients older than 70 years less than 10% of patients were free from any comorbidities, which is in line with the published literature .
In our evaluated population, an increase in the number of comorbid conditions, when disregarding their severity, did not correlate directly with worsening of the performance status. But in contrast to for example Coebergh et al., we did not limit comorbidities to serious diseases, as the purpose of our study was to indicate the potential of interaction of comorbidities with specific treatment planning and not to show an impact on survival .
Two-thirds of our patients were in palliative setting and 50% were planned for the first-line therapy. One-third of patients were in the curative setting (i.e. neoadjuvant, adjuvant or curative setting). In contrast, although the population in our series presented on average with a good performance status, we observed a high number of patients (87%) taking comedication regardless of the underlying reason.
These findings are important as various factors including comorbidity may lead to a higher risk of cancer treatment-related toxicity, as shown by Hurria et al. who developed a valuable prediction score in this regard . Treatment-related toxicity may lead to an inferior outcome, which is also influenced by either delayed diagnosis or limited use of chemotherapy in patients with comorbidities [10, 18]. Just one example of novel treatments and the needed caution when treating patients who are more commonly having both higher frequency of comorbidities and of comedications is given by the higher rate of increased toxicity of CDK 4/6 inhibitors in elderly compared to younger patients.
Facing these concerns about the possibility of increased toxicity clinicians are less likely to offer standard chemotherapy or most effective treatment to elderly patients or patients with comorbidities and are prone to accept even less efficacy or limited benefit of and alternative treatment chosen [19, 20]. Due to increasing importance of comorbidities and elderly in cancer treatment, guidelines have been published to support balanced decisions and trials are being designed to specifically address this population of patients [21, 22].
On the other hand, lacking data on elderly and/or comorbid patients might lead to a misleading assumption of a safe drug application, which is especially true for newer drugs, e.g. anti-VEGF antibodies, TKIs or novel immunotherapies, resulting in more complications and toxicities than reported in randomised trials .
Comedication is of special interest due to the fact that modern biologicals—especially TKIs—have the potential of interaction at the metabolizing cytochrome P‑450 enzyme system (CYP) or drug transporters [24, 25]. Due to a large degree of interindividual variability of these enzymes, overlapping toxicities and pharmacokinetic interactions of targeted therapies with various accompanying comedications have to be taken into consideration in patients with comorbid conditions . Findings from our observational study underline the importance of not only taking the individual patient’s cancer stage into consideration, but also comorbidities and comedication when deciding on individual tumour-specific treatment. The risk–benefit evaluation in the daily oncology practice situation may substantially differ from a highly biased clinical trial scenario. Individualized medical evaluation and thorough clinical judgement may be necessary to avoid additional toxicities and to preserve appropriate efficacy.
The high proportion of patients with comorbidities and corresponding medication represents a substantial challenge for medical oncologists in selecting the optimal tumour-specific treatment. These conditions require special precautions in order to avoid potential interactions and unexpected adverse reactions from prescribed cancer-specific treatment and indicate that there is an increasing need for multidisciplinary care and treatment decisions . Systemic anticancer treatment of an elderly and comorbid patient population deserves a profound knowledge in the management of noncancerous diseases. Therefore, the central role of a medical oncologist within interdisciplinary teams for a holistic perception of an individual cancer patient is stressed and implicates that young oncologists should receive comprehensive training in the management of the most relevant noncancerous diseases to be handled in an elderly population.
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Open access funding provided by Medical University of Graz.
Conflict of interest
M. Balic, W. Hilbe, S. Gusel, M. Fiegl, H. Ludwig, B. Mayrbäurl, J. Thaler, H. Samonigg, K. Hegenbarth, F. Eisner, B. Mlineritsch, R. Greil, M. Schandl, A. Weltermann, A. Petzer, M. Fuchs, W. Stangl, P. Krippl, R. Stauder, and H. Stöger declare that they have no competing interests.
We dedicate this study to our colleague, Ferdinand Ploner, who died in a tragic accident during the study.
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Balic, M., Hilbe, W., Gusel, S. et al. Prevalence of comorbidity in cancer patients scheduled for systemic anticancer treatment in Austria. memo 12, 290–296 (2019). https://doi.org/10.1007/s12254-019-00542-7
- Drug interactions
- Multiple chronic conditions
- Adverse events