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Treatment and clinical results in childhood AML in Greece

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Abstract

Background

The primary objective of our study is to describe the clinical results of children with AML, treated with BFM protocols, in two institutions in Greece.

Patients and methods

Between January 1997 and December 2011, 84 children with primary and secondary AML were treated with BFM AML 93, 98 and 2004 protocol and were eligible for evaluation.

Results

Median follow-up for survivors was 86.3 months. The most usual cytogenetic abnormalities t(8;21), t(15;17) and Myeloid/Lymphoid (MLL) rearrangement were detected in eight, six, and nine children respectively. Out of the 73 patients with primary AML, three died before completion of first induction. Only one has never responded to chemotherapy and eight patients had M2 or M3 bone marrow after induction and required more than one courses to achieve remission. On the whole, 46/70 (65.7 %) patients are alive, in remission. Out of 24 patients who suffered from relapse, only seven are alive in second remission. The event-free survival in standard and high risk group was 17/21 (80.9 %) and 31/52 (59.6 %), respectively, with the difference being statistically significant.

Conclusions

The major cause of mortality in children with AML in our institutions was recurrence of disease. Supportive care, molecular features of the disease, and response to therapy are increasingly used to optimize treatment for all patients.

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References

  1. Woods W. Curing childhood acute myeloid leukemia (AML) at the half-way point: promises to keep and miles to go before we sleep. Pediatr Blood Cancer. 2006;46:565–69.

    Article  PubMed  Google Scholar 

  2. Pession A, Massetti R, Rizarri C, et al. Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia. Blood. 2013;122(2):170–8.

    Article  PubMed  CAS  Google Scholar 

  3. Rubnitz JE, Inaba H. Childhood acute myeloid leukemia. Br J Haematol. 2012;159(3):259–76.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Creutzig U, Zimmermann M, Dworzak MN, et al. Development of a curative treatment within the AML-BFM studies. Klin Padiatr. 2013;225(Suppl 1):p. 79–86.

    Google Scholar 

  5. Sung L, Aplenc R, Alonzo TA, et al. Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from Children’s Oncology Group. Blood. 2013;121(18):3573–7.

    Article  PubMed  CAS  Google Scholar 

  6. O’Brien T, Russell S, Vowels M, et al. Results of consecutive trials for children newly diagnosed with acute myeloid leukemia from the Australian and New Zealand Children’s Cancer Study Group. Blood. 2002;100:2708–16.

    Article  PubMed  Google Scholar 

  7. Lange B, Smith F, Feusner J, et al. Untreated pediatric acute myeloid leukemia: a report from the children’s outcomes in CCG-2961, a children’s oncology group phase 3 trial for oncology group. Blood. 2009;111:1044–53.

    Article  CAS  Google Scholar 

  8. Rubnitz JE, Inaba H, Dahl G, et al. Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial. Lancet Oncol. 2010;11(6):543–52.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Kaspers G, Zwaan C. Pediatric acute myeloid leukemia: towards high-quality cure of all patients. Hematologica. 2007;92:1519–32.

    Article  Google Scholar 

  10. de Botton SC, Chevret S, et al. Outcome of childhood acute promyelocytic leukemia with all-trans-retinoic acid and chemotherapy. J Clin Oncol. 2004;22(8):1404–12.

    Article  PubMed  CAS  Google Scholar 

  11. Sanz M, Grimwade D, Tallman M, et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 2009;113(9):1875–91.

    Article  PubMed  CAS  Google Scholar 

  12. Manola KN, Panitsas F, Polychronopoulou S, et al. Cytogenetic abnormalities and monosomal karyotypes in children and adolescents with acute myeloid leukemia: correlations with clinical characteristics and outcome. Cancer Genet. 2013;206(3):63–72.

    Article  PubMed  CAS  Google Scholar 

  13. Harrison C, Hills R, Moorman A, et al. Cytogenetics of childhood acute myeloid leukemia: United Kingdom medical research council treatment trials AML 10 and 12. J Clin Oncol. 2010;28(16):2674–81.

    Article  PubMed  Google Scholar 

  14. von Neuhoff CR, Sander A, et al. Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98. J Clin Oncol. 2010;28(16):2682–9.

    Article  CAS  Google Scholar 

  15. Kavcic M, Fisher BT, Li Y, et al. Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States. Cancer. 2013;119(10):1916–23.

    Article  PubMed  CAS  Google Scholar 

  16. Kurt B, Flynn P, Shenep JL, et al. Prophylactic antibiotics reduce morbidity due to septicaemia during intensive treatment for pediatric acute myeloid leukemia. Cancer. 2008;113(2):376–82.

    Article  PubMed  Google Scholar 

  17. Johannsen KH, Handrup MM, Lausen B, Schrøder H, Hasle H. High frequency of streptococcal bacteraemia during childhood AML therapy irrespective of dose of cytarabine. Pediatr Blood Cancer. 2013;60(7):1154–60.

    Article  PubMed  Google Scholar 

  18. Creutzig U, van den Heuvel-Eibrink M, Gibson B, et al. Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel. Blood. 2012;120(16):3187–205.

    Article  PubMed  CAS  Google Scholar 

  19. Creutzig U, Zimmermann M, Lehrnbecher T, et al. Less toxicity by optimizing chemotherapy, but not by addition of granulocyte colony-stimulating factor in children and adolescents with acute myeloid leukemia: results of AML-BFM 98. J Clin Oncol. 2006;24(27):4499–506.

    Article  PubMed  CAS  Google Scholar 

  20. Rubnitz JE, Pounds S, Cao X, et al. Treatment outcome in older patients with childhood acute myeloid leukemia. Cancer. 2012;118(24):6253–9.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Niewerth D, Creutzig U, Bierings MB, Kaspers GJ. A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia. Blood. 2010;116(13):2205–14.

    Article  PubMed  CAS  Google Scholar 

  22. Inaba H, Coustan-Smith E, Cao X, et al. Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia. J Clin Oncol. 2012;30(29):3625–32.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Pui C, Carroll W, Meshinchi S, Arceci R. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol. 2011;29(5):551–65.

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Hematology-Oncology, “Agia Sofia” Children’s Hospital, Thivon and Papadiamantopoulou, 11527, Athens, Greece

    Sofia Polychronopoulou,  Vasilios Papadakis,  Georgia Avgerinou &  Mirella Abatzidou

  2. Oncology Department, Children’s Hospital “P. & A. Kyriakou”, Thivon and Levadias, 11527, Athens, Greece

    Margarita Baka,  Marina Servitzoglou,  Apostolos Pourtsidis &  Helen Kosmidis

Authors
  1. Sofia Polychronopoulou
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  2. Margarita Baka
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  3. Marina Servitzoglou
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  4. Vasilios Papadakis
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  5. Apostolos Pourtsidis
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  6. Georgia Avgerinou
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  7. Mirella Abatzidou
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  8. Helen Kosmidis
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Corresponding author

Correspondence to Marina Servitzoglou.

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Polychronopoulou, S., Baka, M., Servitzoglou, M. et al. Treatment and clinical results in childhood AML in Greece. memo 7, 50–55 (2014). https://doi.org/10.1007/s12254-013-0112-x

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  • DOI: https://doi.org/10.1007/s12254-013-0112-x

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