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Outcome of Acute Myeloid Leukemia in Children Adolescents and Young Adults Treated with an Uniform Protocol in Casablanca, Morocco

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Treatment of acute myeloblastic leukemia in children, adolescents and young adults (AYA) is a challenge in low-income countries. To evaluate treatment outcomes of children (≤ 15 years) and AYA (15–30 years) diagnosed with novo AML and treated in a single center according to the AML-MA 2011 protocol. From January 2011 to December 2015, eligible patients (age ≤ 30 years) with novo AML had been enrolled on a uniform treatment protocol. The diagnosis was confirmed according to the FAB classification using the WHO 2008 criteria. Patients with WBC ≥ 50 G/L had pretreated 4 days of hydroxyurea followed by two inductions and two consolidations. Supportive care consisted of transfusion of labile blood products, antibiotics and antifungals, and patient and family education by the hygiene team. 155 patients were recruited, 41 were < 15 years old (22 boys, median age 7.8 years). Of the 114 AYA enrolled, (48 women, median age 23 years). Complete remission after two inductions was 28/41 (68.3%) of the children, including 100% of the children in the favorable group and 71/114 (62.3%) of the AYA, 22 of whom (68.7%) were in the favorable group. The number of deaths among children was 6 (14.6%). The evaluation of the AML-MA-2011 National Protocol in the age groups of children and AYA reveals that the objective of treatment is almost achieved in terms of complete remission in the two age groups.

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Authors and Affiliations

  1. Department of Hematology and Pediatric Oncology, Hospital 20 August, University Hassan II Casablanca, Casablanca, Morocco

    B. Housou, S. Cherkaoui, M. Lamchahab, R. Massi, N. Khoubila, M. Qachouh, M. Rachid, A. Madani & A. Quessar

  2. McMaster University, Hamilton, Canada

    U. H. Athale

  3. Clinical Hematology and Pediatric Oncology Department, Hospital 20 August, CHU Ibn Rochd, 20250, Casablanca, Morocco

    B. Housou, S. Cherkaoui, M. Lamchahab, R. Massi, N. Khoubila, M. Qachouh, M. Rachid, A. Madani & A. Quessar

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  1. B. Housou
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  2. S. Cherkaoui
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  3. M. Lamchahab
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  4. R. Massi
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  5. N. Khoubila
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  6. M. Qachouh
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  7. M. Rachid
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  8. A. Madani
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  9. U. H. Athale
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  10. A. Quessar
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Correspondence to B. Housou.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Housou, B., Cherkaoui, S., Lamchahab, M. et al. Outcome of Acute Myeloid Leukemia in Children Adolescents and Young Adults Treated with an Uniform Protocol in Casablanca, Morocco. Indian J Hematol Blood Transfus 35, 255–259 (2019). https://doi.org/10.1007/s12288-018-1013-2

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  • DOI: https://doi.org/10.1007/s12288-018-1013-2

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