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Treatment results of childhood acute myeloid leukemia in Serbia

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Abstract

We present the results of a retrospective study of acute myeloid leukemia (AML) treatment in Serbia in the period 2000–2012. Treatment was performed in four centers, two of which were located in Belgrade, one in Nis, and one in Novi Sad. Children affected by non-acute promyelocytic leukemia (non-APL) subtypes received treatment regimens derived from protocols of Berlin Frankfurt Munster AML study group, whereas children with APL were treated according to the AIEOP/GIMEMA ATRA plus Idarubicin “AIDA” protocol. Total number of patients was 106, out of whom 48 were girls (45.3 %) and 58 boys (54.7 %); median age at diagnosis was 9.0 years (range 1 month–17.9 years). In total, 82.1 % of patients achieved complete remission after induction treatment. Twelve patients (11.3 %) died during induction, before achieving complete remission; there were nine deaths during remission (10.5 %) and 20 patients relapsed (23.2 %). Median time of follow-up was 54 months. Two patients (1.9 %) were lost to follow-up. Event-free survival was 50.3 % and overall survival was 58.9 %.

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Conflict of interest

The authors report no conflict of interest.

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Authors and Affiliations

  1. Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000, Belgrade, Serbia

    Krstovski Nada MD,  Kuzmanovic Milos MD,  Dokmanovic Lidija MD,  Skoric Dejan MD &  Janic Dragana MD

  2. Medical Faculty, University of Novi Sad, Novi Sad, Serbia

    Konstantinidis Nada MD

  3. Department of Hematology and Oncology, University Children’s Hospital, Tirsova 10, 11000, Belgrade, Serbia

    Krstovski Nada MD,  Dokmanovic Lidija MD,  Skoric Dejan MD, Lazic Jelena MD, MSc, Rodic Predrag MD, MSc &  Janic Dragana MD

  4. Department of Hematology, Mother and Child Healthcare Institute “Dr Vukan Cupic”, Radoja Dakica 8, 11000, Belgrade, Serbia

    Kuzmanovic Milos MD,  Vujic Dragana MD, Micic Dragan MD, Slavkovic Bojana MD, Jovanovic Ankica MD, PhD & Jovic Milena MD, MSc

  5. Department of Hematology and Oncology, Clinic for Childrens Internal Diseases, Nis, Serbia

    Kostic Gordana MD

Authors
  1. Krstovski Nada MD
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  2. Kuzmanovic Milos MD
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  3. Vujic Dragana MD
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  4. Dokmanovic Lidija MD
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  5. Micic Dragan MD
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  6. Slavkovic Bojana MD
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  7. Skoric Dejan MD
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  8. Lazic Jelena MD, MSc
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  9. Jovanovic Ankica MD, PhD
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  10. Jovic Milena MD, MSc
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  11. Konstantinidis Nada MD
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  12. Kostic Gordana MD
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  13. Rodic Predrag MD, MSc
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  14. Janic Dragana MD
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Corresponding author

Correspondence to Janic Dragana MD.

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Nada, K., Milos, K., Dragana, V. et al. Treatment results of childhood acute myeloid leukemia in Serbia. memo 6, 63–68 (2013). https://doi.org/10.1007/s12254-012-0051-y

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  • DOI: https://doi.org/10.1007/s12254-012-0051-y

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