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Association of Genetic Variations in RTN4 3’-UTR with Risk of Uterine Leiomyomas

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Pathology & Oncology Research

Abstract

This pilot case-control study was conducted to test the hypothesis that the TATC (rs71682890) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3’-UTR are associated with the susceptibility to uterine leiomyoma (UL). The study recruited 286 premenopausal women with UL and 450 unrelated postmenopausal women not presenting the disease as control subjects. The polymorphisms of rs71682890 and rs34917480 were genotyped with the method of polymerase chain reaction polyacrylamide gel electrophoresis (PCR - PAGE). No statistically significant association was observed between the TATC insertion/deletion polymorphism and UL risk. However, increased UL risk was identified to be significantly associated with CAA insertion/deletion polymorphism in the recessive and codominant model. The present study provided evidence for the first time that CAA polymorphism in RTN4 3’-UTR, but not TATC polymorphism may be involved in susceptibility to UL.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 30871044, No. 81172440 and No. 30901596), the Applied Basic Research Programs of Science and Technology Commission Foundation of Sichuan Province (No. 2010SZ0122 and No. 2009SZ0163), and by Program for Chang-jiang Scholars and Innovative Research Team in University.

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Authors and Affiliations

  1. Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China

    Kui Zhang, Peng Bai & Lin Zhang

  2. Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, People’s Republic of China

    Shaoqing Shi

  3. Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China

    Bin Zhou, Yanyun Wang & Yaping Song

  4. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China

    Li Rao

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  1. Kui Zhang
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  2. Peng Bai
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  3. Shaoqing Shi
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  7. Li Rao
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  8. Lin Zhang
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Correspondence to Lin Zhang.

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Kui Zhang and Peng Bai have contributed equally to this work.

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Zhang, K., Bai, P., Shi, S. et al. Association of Genetic Variations in RTN4 3’-UTR with Risk of Uterine Leiomyomas. Pathol. Oncol. Res. 19, 475–479 (2013). https://doi.org/10.1007/s12253-013-9604-6

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  • DOI: https://doi.org/10.1007/s12253-013-9604-6

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