Skip to main content

Advertisement

SpringerLink
Log in

Distribution of Basement Membrane in Supraglottic Carcinoma

  • Published:
Pathology & Oncology Research

Abstract

The object of this study was to assess the distribution of basement membrane in supraglottic squamous cell carcinomas. Expression of type IV collagen was detected by immunohistochemistry in resected supraglottic squamous cell carcinomas, and the correlation was examined between expression of type IV collagen and clinicopathological factors and cervical lymph node metastasis of supraglottic squamous cell carcinomas patients. An intact, continuous basement membrane was found in 17 cases (42.5%), while partial or widespread loss of the basement membrane was detected in the other 23 cases (57.5%). Heavily defective basement membrane was much more frequently observed in cases with poor histological differentiation (P < 0.05). Cases with BM destruction were more likely to be accompanied by cervical lymph node metastasis (P < 0.05). These data suggest that assessing the distribution pattern of basement membrane may be helpful in evaluating the malignancy grading of supraglottic squamous cell carcinomas and the potential occurrence of cervical lymph node metastasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

BM:

Basement Membrane

SSCC:

Supraglottic Squamous Cell Carcinomas

References

  1. Brown PD, Levy AT, Margulies IM, Liotta LA, Stetler-Stevenson WG (1990) Independent distribution pattern and celluler processing of the 72 KD type IV collagenase and interstital collagenase in human tumorgenic cell lines. Cancer Res 50:6184–6191

    PubMed  CAS  Google Scholar 

  2. Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL (1990) Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J Biol chem 265:11421–11424

    PubMed  CAS  Google Scholar 

  3. Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI (1988) H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J Biol Chem 263:6579–6587

    PubMed  CAS  Google Scholar 

  4. Lunt SJ, Chaudary N, Hill RP (2009) The tumor microenvironment and metastatic disease. Clin Exp Metastasis 26:19–34

    Article  PubMed  Google Scholar 

  5. Hay ED (1982) Cell biology of ertracellular matrix. Plenum, New York

    Google Scholar 

  6. Liotta LA (1984) Tumor invasion and metastases: role of the basement membrane. Am J Pathol 117:339–348

    PubMed  CAS  Google Scholar 

  7. Leblond CP, Inoue S (1989) Structure, composition and assembly of basement membrane. Am J Anat 185:367–390

    Article  PubMed  CAS  Google Scholar 

  8. Sakr WA, Zarbo RJ, Jacobs JR, Crissman JD (1987) Distribution of basement membrane in squamous cell carcinoma of the head and neck. Hum pathol 18:1043–1050

    Article  PubMed  CAS  Google Scholar 

  9. Carter RL, Burman JF, Barr L, Gusterson BA (1985) Immunohistochemical localization of basement membrane type IV Collagen in invasive and metastatic squamous carcinomas of the head and neck. J Pathol 147:159–164

    Article  PubMed  CAS  Google Scholar 

  10. Martinez-Hernandez A, Amenta PS (1983) The basement membrane in pathology. Lab Invest 48:656–677

    PubMed  CAS  Google Scholar 

  11. Barsky SH, Siegal GP, Jannotta F, Liotta LA (1983) Loss of basement membrane components by invasive tumors but not by their begin counterparts. Lab Invest 49:140–147

    PubMed  CAS  Google Scholar 

  12. Yamamoto E, Kohama G, Sunakawa H, Iwai M, Hiratsuka H (1983) Mode of invasion, bleomycin sensitivity and clinical course in squamous cell carcinoma of the oral cavity. Cancer 51:2175–2180

    Article  PubMed  CAS  Google Scholar 

  13. Radisky DC (2005) Epithelial-mesenchymal transition. J Cell Sci 118:4325–4326

    Article  PubMed  CAS  Google Scholar 

  14. Bienz M (2005) beta-Catenin a pivot between cell adhesion and Wnt signalling. Curr Biol 15:64–67

    Article  Google Scholar 

  15. Bonitsis N, Batistatou A, Karantima S, Charalabopoulos K (2006) The role of cadherin/catenin complex in malignant melanoma. Exp Oncol 28:187–193

    PubMed  CAS  Google Scholar 

  16. Andreasen PA, Egelund R, Petersen HH (2000) The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57:25–40

    Article  PubMed  CAS  Google Scholar 

  17. Osinsky SP, Ganusevich II, Bubnovskaya LN, Valkovskaya NV, Kovelskaya AV, Sergienko TK, Zimina SV (2005) Hypoxia level and matrix metalloproteinases-2 and–9 activity in Lewis lung carcinoma: correlation with metastasis. Exp Oncol 27:202–205

    PubMed  CAS  Google Scholar 

  18. Rofstad EK, Rasmussen H, Galappathi K, Mathiesen B, Nilsen K, Graff BA (2002) Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res 62:1847–1853

    PubMed  CAS  Google Scholar 

  19. Visser R, van der Beek JM, Havenith MG, Cleutjens JP, Bosman FT (1986) Immunocytochemical detection of basement membrane antigens in the histopathological evaluation of laryngeul dysplasia and neoplasia. Histopathology 10:171–180

    Article  PubMed  CAS  Google Scholar 

  20. Répássy G, Czigner J, Ribári O, Lapis K (1988) The barrier-like role of activated connective tissue against the spread of supraglottic carcinoma. Arch Otorhinolaryngol 245:151–154

    Article  PubMed  Google Scholar 

  21. Wang Y, Tian J, Ren Z (1997) The relationship between histologic grading of malignancy and regional lymph node metastasis in squamous cell carcinoma of larynx. J Clin Otorhinolaryngol (China) 11:160–162

    CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by Scientific Research Grants (30540080) from the National Natural Science Foundation of China and a grant from the Society for the Promotion of International Oto-Rhino-Laryngology (SPIO) of Japan.

Author information

Authors and Affiliations

  1. Department of Otolaryngology, the 1st Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Yan Wang, He Yu & Z. M. Pan

  2. Department of Surgery, the 4th Affiliated Hospital, China Medical University, ShenYang, 110001, China

    W. Y. Sun

  3. Laryngal Cancer Research Institution, the 1st Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Yan Wang & Chao Guan

Authors
  1. Yan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Y. Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chao Guan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. He Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Z. M. Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yan Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, Y., Sun, W.Y., Guan, C. et al. Distribution of Basement Membrane in Supraglottic Carcinoma. Pathol. Oncol. Res. 17, 1–5 (2011). https://doi.org/10.1007/s12253-010-9250-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-010-9250-1

Keywords

Search

Navigation