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Automatic formation of hypotheses on the relationships between structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens HK44

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Abstract

Seven hypotheses on relationships between the structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens were formulated using GUHA (General Unary Hypotheses Automaton) on a training set of 37 compounds. Prediction of bioluminescence response of 12 new naphthalene analogs was successful in 69 % cases and resulted in rejection of single hypothesis. The results demonstrate applicability of GUHA in structure-activity research, especially for qualitative data.

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Abbreviations

Faq:

Fisher association quantifier

ff-table:

four-fold table

Fimpl:

founded implication quantifier

GUHA:

general unary hypotheses automaton

nah :

genes of naphthalene degradation pathway

P.f. :

Pseudomonas fluorescens

(Q)SAR:

(quantitative) structure-activity relationship

RBL:

relative bioluminescence

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Authors and Affiliations

  1. Faculty of the Environment, J. E. Purkyně University in Ústí nad Labem, 400 96, Ústí nad Labem, Czech Republic

    J. Trögl

  2. Škábova 1/3052, 106 00, Prague 10, Czech Republic

    J. Hálová

  3. Institute of Chemical Process Fundamentals v.v.i., Academy of Sciences of the Czech Republic, 165 02, Prague 6, Czech Republic

    G. Kuncová

  4. Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, 532 10, Pardubice, Czech Republic

    P. Pařík

Authors
  1. J. Trögl
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  2. J. Hálová
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  3. G. Kuncová
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  4. P. Pařík
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Correspondence to J. Trögl.

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Trögl, J., Hálová, J., Kuncová, G. et al. Automatic formation of hypotheses on the relationships between structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens HK44. Folia Microbiol 55, 411–417 (2010). https://doi.org/10.1007/s12223-010-0069-7

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  • DOI: https://doi.org/10.1007/s12223-010-0069-7

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