Skip to main content

Advertisement

SpringerLink
Log in

Alkaline sucrose as a solvent for delivery of water-insoluble drugs

  • Published:
Folia Microbiologica Aims and scope Submit manuscript

Abstract

Alkaline sucrose solution was demonstrated to be a good solvent for the solubilization of water-insoluble drugs. At high concentration and alkaline pH, sucrose solubilizes water-insoluble molecules through intramolecular conformations. Tetracyline and chloramphenicol, when dissolved in alkaline sucrose solution, retained their bactericidal activity. Gel permeation-chromatography analysis and atomic-force-microscopy studies confirmed the formation of sucrose-antibiotics complex.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

AFM:

atomic force microscopy

GPC:

gel permeation chromatography

Me2SO:

dimethyl sulfoxide (‘DMSO’)

MIC:

minimum inhibitory concentration

PBS:

phosphate-buffered saline

References

  • Azim A., Shah V., Doncel G.F., Peterson N., Gao W., Gross R.: Amino acid conjugated sophorolipids: a new family of functionalized glycolipids. Bioconjugate 17, 1523–1529 (2006).

    Article  CAS  Google Scholar 

  • Blevins J.E., Stanley B.G., Reidelberger R.D.: DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol.Biochem.Behav. 71, 277–282 (2002).

    Article  PubMed  CAS  Google Scholar 

  • Burgess J.L., Hamner A.P., Robertson W.O.: Sulfhemoglobinemia after dermal application of DMSO. Vet.Hum.Toxicol. 40, 87–89 (1998).

    PubMed  CAS  Google Scholar 

  • Coe E.M., Bowen L.H., Bereman R.D., Speer J.A., Monte W.T., Scaggs L.: A study of an iron dextran complex by Mössbauer spectroscopy and x-ray diffraction. J. Inorg.Biochem. 57, 63–71 (1995).

    Article  CAS  Google Scholar 

  • Davis J.M., Rowlen S.D., Braine H.G., Piantadosi S., Santos G.W.: Clinical toxicity of cryopreserved bone marrow graft infusion. Blood 75, 781–786 (1990).

    PubMed  CAS  Google Scholar 

  • Dudeck O., Jordon O., Hoffmann K.T., Okuducu A.F., Tesmer K., Kreuzer-Nagy T., Rüfenacht D.A., Doelker E., Felix R.: Organic solvents as vehicles for precipitating liquid embolics: a comparative angiotoxicity study with superselective injections of swine rete mirabile. Am.J.Neuroradiol. 27, 1900–1906 (2000).

    Google Scholar 

  • Hameroff S.R., Otto C.W., Kanel J., Weinstein P.R., Blitt C.D.: Acute cardiovascular effects of dimethylsulfoxide. Ann.N.Y. Acad.Sci. 411, 94–99 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Hardin R., Pierre J., Schulze R., Mueller C.M., Fu S.L., Wallner S.R., Stanek A., Shah V., Gross R.A., Weedon J., Nowakowski M., Zenilman M.E., Bluth M.H.: Sophorolipids improve sepsis survival: effects of dosing and derivatives. J.Surg. Res. 142, 314–319 (2007).

    Article  PubMed  CAS  Google Scholar 

  • Kacuráková M., Mathlouthi M.: FTIR and laser-Raman spectra of oligosaccharides in water: characterization of the glycosidic bond. Carbohydr.Res. 284, 145–157 (1996).

    Article  PubMed  Google Scholar 

  • Kudasheva D.S., Lai J., Ulman A., Cowman M.K.: Structure of carbohydrate-bound polynuclear iron oxyhydroxide nanoparticles in parenteral formulations. J.Inorg.Biochem. 98, 1757–1769 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Laurent A., Mottu F., Chapot R., Zhang J.Q., Jordon O., Rufenacht D.A., Doelker E., Merland J.J.: Cardiovascular effects of selected water-miscible solvents for pharmaceutical injections and embolization materials: a comparative hemodynamic study using a sheep model. PDA J.Pharm.Sci.Technol. 61, 64–74 (2007).

    PubMed  CAS  Google Scholar 

  • Marshall P.R., Rutherford D.: Physical investigations on colloidal iron-dextran complexes J.Coll.Inter. Sci. 37, 390–402 (1971).

    Article  CAS  Google Scholar 

  • Mottu F., Laurent A., Rufenacht D.A., Doelker E.: Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxicity data. PDA J.Pharm.Sci.Technol. 54, 456–469 (2000).

    PubMed  CAS  Google Scholar 

  • Mottu F., Stelling M.J., Rufenacht D.A., Doelker E.: Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection. PDA J.Pharm.Sci.Technol. 55, 16–23 (2001).

    PubMed  CAS  Google Scholar 

  • Rapoport A.P., Rowe J.M., Packman C.H., Ginsberg S.J.: Cardiac arrest after autologous marrow infusion. Bone Marrow Transplant. 7, 401–403 (1991).

    PubMed  CAS  Google Scholar 

  • Samoszuk M., Reid M.E., Toy P.T.: Intravenous dimethylsulfoxide therapy causes severe hemolysis mimicking a hemolytic transfusion reaction. Transfusion 23, 405 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Sipos P., Pierre T.G., Tombacz T., Webb J.: Rod-like iron(III) oxyhydroxide particles in iron(III)-polysaccharide solutions. J.Inorg. Biochem. 58, 129–138 (1995).

    Article  CAS  Google Scholar 

  • Styler M.J., Topolsky D.L., Crilley P.A., Covalesky V., Bryan R., Bulova S., Brodsky I.: Transient high grade heart block following autologous bone marrow infusion. Bone Marrow Transplant. 10, 435–438 (1992).

    PubMed  CAS  Google Scholar 

  • Topacoglu H., Karcioglu O., Ozsarac M., Oray D., Niyazi O.D., Tuncok Y.: Massive intracranial hemorrhage associated with the ingestion of dimethylsulfoxide. 46, 138–140 (2004).

    Google Scholar 

  • Tran V.H., Brady J.W.: Disaccharide conformational flexibility — I. An adiabatic potential energy map for sucrose. Biopolymers 29, 961–976 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa K., Yagi K., Nanjo S., Seno A., Shiono T., Tobe K., Suzuki S.: Contrast agent for magnetic resonance angiography: experimental evaluation of superparamagnetic iron oxide composed of polysaccharide complex involving chondroitinsulfuric acid. Acad.Radiol. 3, 297S–298S (1996).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, Dowling College, Oakdale, NY, 11955, USA

    V. Shah, D. Badia & D. Kudasheva

Authors
  1. V. Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Badia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Kudasheva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. Shah.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shah, V., Badia, D. & Kudasheva, D. Alkaline sucrose as a solvent for delivery of water-insoluble drugs. Folia Microbiol 54, 195–198 (2009). https://doi.org/10.1007/s12223-009-0030-9

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12223-009-0030-9

Keywords

Search

Navigation