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Electrospun SrO-Incorporated Nanofiber Membranes for Biomedical Applications

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Abstract

Bioactive ceramics have gained increasing interest in biomedical applications. Strontium (Sr)-based ceramics show unique bioactivity in stimulating cell proliferation and migration and promoting angiogenesis. Incorporation of bioactive ceramics into nanofibers represents a facile approach to alter the material properties of electrospun nanofiber membranes. Herein, we prepared SrO-incorporated nanofiber membranes by electrospinning and investigated the effects of SrO particles on the physicochemical properties and cytocompatibility of these membranes. Our results indicate that simple one-stream electrospinning could smoothly introduce SrO particles into poly(L-lactic acid) (PLA)/gelatin nanofibers. SrO-incorporated membranes showed significantly improved wettability but became brittle compared with PLA/gelatin nanofiber membranes. Cells differentially responded to SrO-incorporated membranes: endothelial cells showed greater cell area and coverage on SrO-incorporated membranes; in contrast, fibroblasts were inhibited on these membranes. These findings suggest that SrO-incorporated membranes might find opportunities in specific biomedical applications in which pro-angiogenesis and antiadhesion are simultaneously demanded.

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Acknowledgements

The authors acknowledge financial support from the Science and Technology Commission of Shanghai Municipality (19440741300, 20DZ2254900).

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  1. Zhe Chen and Jitao Fan contributed equally to the manuscript.

Authors and Affiliations

  1. Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Department of Biomedical Engineering, Donghua University, Shanghai, 201620, People’s Republic of China

    Zhe Chen, Yangfan Ding, Yunlong Zhang, Ahmed I. Abd-Elhamid, Jinglei Wu & Binbin Sun

  2. Department of Pediatrics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, People’s Republic of China

    Jitao Fan

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  1. Zhe Chen
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Contributions

Binbin Sun and Zhe Chen designed the study and wrote the manuscript. Zhe Chen, Jitao Fan, Yangfan Ding, and Jinglei Wu performed the experiments. Binbin Sun, Ahmed I. Abd-Elhamid, and Jinglei Wu analyzed and interpreted the data. All authors discussed the results and approved the final version of this article.

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Correspondence to Binbin Sun.

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Chen, Z., Fan, J., Ding, Y. et al. Electrospun SrO-Incorporated Nanofiber Membranes for Biomedical Applications. Fibers Polym 24, 3775–3786 (2023). https://doi.org/10.1007/s12221-023-00361-y

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