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Ultrathin Polymer Fibers Coated with an Amorphous SiO2–CaO–P2O5 Bioactive Powders for Biomedical Applications

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Abstract

The development of new biomaterials with improved properties is a trend in tissue regeneration. In this way, an innovative approach is employed in this work for obtaining polymer fibers coated with nanoparticles resulting from the simultaneous application of poly (lactic acid) (PLA)/polycaprolactone (PCL) electrospinning and bioactive particles from an amorphous multicomponent silica–calcium–phosphorus system (AMS) electrospraying. The osteogenesis was evaluated in vitro and in vivo using male rats, in which total protein, alkaline phosphatase, and biological performance through histological and histomorphometric analysis were discussed. The morphological results assessed by scanning electron microscopy showed a mesh of PLA/PCL fibers associated with AMS. The spraying of 17.44% of AMS particles in the PLA/PCL electrospun fibers decreased the Young’s modulus and tensile strength. However, the amount of AMS particles sprayed was enough to promote a reduction of 17.8% in the measured contact angle values. Phosphatase alkaline higher mean value was also observed in the fibers when in contact with the AMS, but nonstatistical difference was observed (p > 0.05). It was possible to observe the presence of mineralized nodules deposited on the bottom of the plate and between the fibers. The newly formed bone into defect filled with PLA/PCL-AMS fibers was higher than that observed in the control group. These findings suggest PLA/PCL-AMS fibers as a multifunctional composite system that may be attractive for both bone and dental tissue engineering applications.

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Acknowledgements

The authors are grateful to the Brazilian agencies: Coordination for the Improvement of Higher Education Personnel—CAPES, Brazil (Grant CAPES/Print: 8888.572851/2020-00), National Council for Scientific and Technological Development—CNPq, Brazil (Grant PQ: 309406/2019-6), Sao Paulo Research Foundation—FAPESP (Grant: 2019/19594-4 and Grant: 2021/14277-0). The authors thank the use of the multi-user center (NAPCEM) at the Federal University of Sao Paulo (UNIFESP/SJC).

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Authors and Affiliations

  1. Institute of Science and Technology of São José dos Campos, Department of Dental Materials and Prosthodontics, São Paulo State University (Unesp), 777 Eng. Francisco Jose Longo Avenue, São Jose dos Campos, SP, 12245-000, Brazil

    Lilian de Siqueira & Alexandre Luiz Souto Borges

  2. Instituto de Ciência e Tecnologia, Bioceramics Laboratory (BIOCERAM), Universidade Federal de São Paulo, 330 Talim Street-Vila Nair, São Jose dos Campos, SP, 12231-280, Brazil

    Verônica Ribeiro dos Santos & Eliandra de Sousa Trichês

  3. Institute of Science and Technology of São José dos Campos, Department of Bioscience and Oral Diagnosis, São Paulo State University (Unesp), São Jose dos Campos, 12245-000, Brazil

    Juliani Caroline Ribeiro de Araújo, Hugo Gutemberg Patiño de Oliveira Filho & Luana Marotta Reis de Vasconcellos

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  1. Lilian de Siqueira
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de Siqueira, L., dos Santos, V.R., de Araújo, J.C.R. et al. Ultrathin Polymer Fibers Coated with an Amorphous SiO2–CaO–P2O5 Bioactive Powders for Biomedical Applications. Fibers Polym 24, 3139–3150 (2023). https://doi.org/10.1007/s12221-023-00287-5

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