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3D Printing Silk Fibroin/Hydroxyapatite/Sodium Alginate Composite Scaffolds for Bone Tissue Engineering

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Abstract

Silk Fibroin (SF) is a protein polymer with great biocompatibility, which can promote cell proliferation and differentiation, and enhance bone repair. In this paper, the effects of distinctive concentrations of SF solutions on the physicochemical and biological properties of the SF-HA-SA scaffolds were investigated. The SF-HA-SA porous scaffolds were prepared utilizing the pneumatic extrusion 3D printing technique, composed of hydroxyapatite (HA) and different concentrations of SF solution, and sodium alginate (SA) as a binder. The results shown the SF-HA-SA scaffolds can promote cell proliferation with the increase of SF concentration in scaffolds, and the strength meets the necessities of trabecular bone defects of bone and cartilage repair. It provides an important reference for the application of SF in bone tissue engineering.

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Data availability

The datasets used or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors gratefully acknowledge the financial supports from the National Natural Science Foundation of China (No. 32001017, 31960207, 52061031). This work was also supported by Nanchang Municipal Key Laboratory of 3D Bioprinting Technology and Equipment (No. 2019NCZDSY001).

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Authors and Affiliations

  1. School of Advanced Manufacturing, Nanchang University, Nanchang, 330031, People’s Republic of China

    Zhenyu Xu, Ke Li, Kui Zhou, Shuiyuan Li, Hongwei Chen, Jiaqi Zeng & Rugang Hu

  2. Nanchang Municipal Key Laboratory of 3D Bioprinting Technology and Equipment, Nanchang University, Nanchang, 330031, People’s Republic of China

    Kui Zhou

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  1. Zhenyu Xu
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Correspondence to Kui Zhou.

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Xu, Z., Li, K., Zhou, K. et al. 3D Printing Silk Fibroin/Hydroxyapatite/Sodium Alginate Composite Scaffolds for Bone Tissue Engineering. Fibers Polym 24, 275–283 (2023). https://doi.org/10.1007/s12221-023-00090-2

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