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Modifying Porous Bacterial Cellulose with Chondroitin Sulfate/Gelatin for Improved Biocompatibility

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Abstract

Lacking large pores and insufficient bioactivity are two critical disadvantages of bacterial cellulose (BC). In this study, a new type of coating, chondroitin sulfate (CS) modified with gelatin (Gel), was selected to modify porous bacterial cellulose (PBC) for improved biocompatibility. The PBC was fabricated by adding Gel microspheres in the culture medium of BC, and the PBC-CS/Gel scaffolds were prepared by immersing PBC in the CS solutions followed by Gel modification. The morphology, chemical structure, physicochemical properties, and in vitro cell behavior of the PBC-CS/Gel scaffolds were characterized. The mechanical test shows that the tensile strength and Young's modulus of the PBC scaffold were increased with the introduction of CS/Gel coatings. The in vitro cell studies show that the CS/Gel coatings significantly promote cell proliferation, adhesion, differentiation, and ingrowth into scaffolds. The PBC-CS/Gel scaffolds are expected to be used in tissue engineering.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant nos. 31870963, 51973058, and 32160229), the Key Research and Development Program of Jiangxi Province (Grant no. 20192ACB80008), and the Key Project of Natural Science Foundation of Jiangxi Province (Grant no. 20202ACBL204013).

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Authors and Affiliations

  1. Jiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang, 330013, China

    Honglin Luo, Cheng Yin, Bingbing Zhong, Wei Li, Zhiwei Yang, Quanchao Zhang & Yizao Wan

  2. School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, China

    Honglin Luo & Yizao Wan

  3. Department of Cardiology, Jiangxi Cardiovascular Disease Hospital, Nanchang, 330006, China

    Hongmin Zhu, Yuliang Zhan & Xinyong Cai

  4. Department of Joint Surgery, Tianjin Hospital, Tianjin, 300211, China

    Kaijing Ren

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  1. Honglin Luo
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Correspondence to Quanchao Zhang or Yizao Wan.

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Luo, H., Yin, C., Zhong, B. et al. Modifying Porous Bacterial Cellulose with Chondroitin Sulfate/Gelatin for Improved Biocompatibility. Fibers Polym 24, 975–984 (2023). https://doi.org/10.1007/s12221-023-00036-8

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