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Iron oxyhydroxide nanoparticles: green synthesis and their cytotoxicity activity against A549 human lung adenocarcinoma cells

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Abstract

Iron oxyhydroxide (α-FeOOH, Goethite) is one of the most thermodynamically stable iron oxides and a widespread soil mineral. In this study, a mixture of two phenolic extracts of rosemary and Echinacea was utilized as stabilizing and reducing agents for the synthesis of Goethite (FeOOH) nanoparticles without utilizing harmful toxic solvents. The resulting nanoparticles were characterized by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM)-energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), vibrating-sample magnetometer (VSM), thermogravimetry/differential thermal analysis (TG/DTA), and Brunauer–Emmett-Teller (BET). MTT assay was applied for evaluating the possible toxicity of the nanoparticles against A549 human lung adenocarcinoma cells.

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Acknowledgements

Author thanks from Shahid Beheshti University of Medical Sciences.

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Authors and Affiliations

  1. Department of Chemical and Petroleum Engineering, Sharif University of Technology, 11155-9465 Azadi Avenue, Tehran, Iran

    Hamed Sadeghi

  2. Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran

    Hajar Q. Alijani & Seyedeh-Sharifeh Rahimi

  3. Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

    Shahla Hashemi-Shahraki

  4. Faculty of Nursing and Midwifery, Zabol University of Medical Sciences, Zabol, Iran

    Mahin Naderifar

  5. Department of Surgery, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

    Firoozeh Abolhasani Zadeh

  6. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

    Siavash Iravani

  7. Behbahan Faculty of Medical Sciences, Behbahan, Iran

    Mojtaba Haghighat

  8. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Mehrdad Khatami

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  1. Hamed Sadeghi
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  2. Hajar Q. Alijani
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  8. Mojtaba Haghighat
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Sadeghi, H., Alijani, H.Q., Hashemi-Shahraki, S. et al. Iron oxyhydroxide nanoparticles: green synthesis and their cytotoxicity activity against A549 human lung adenocarcinoma cells. Rend. Fis. Acc. Lincei 33, 461–469 (2022). https://doi.org/10.1007/s12210-022-01065-w

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