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Research Update on Bioreactors Used in Tissue Engineering

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Abstract

Owing to the paucity of donor organs and their acute rejection by the immune system after transplantation, advanced organ failure is one of the major challenges faced by the medical community. Static culturing used for synthesising tissues and organs cannot simulate the in vivo mechanical and biochemical signals; therefore, such artificial organs fail to maintain effective functional activity following transplantation. Tissue engineering can overcome these hurdles by successfully enabling regeneration of tissues and organs in vitro. Bioreactors are pivotal in the development and generation of engineered biological products. They simulate the in vivo microenvironment of tissue growth while also providing various mechanical stimuli and biochemical signals to stem cells to effectively generate transplantable organs or tissues. Various designs and types of bioreactors, their applications, and future research prospects are summarised, which promote functional tissue engineering.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China

    Wenhao Wang  (王文豪), Qian Deng  (邓迁), Lei Qiang  (强磊), Jinwu Wang  (王金武) & Kerong Dai  (戴尅戎)

  2. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Wenhao Wang  (王文豪), Tao Li  (李涛), Yang Liu  (刘洋), Changxu Deng  (邓昌旭), Zhenjiang Ma  (马振江), Jinwu Wang  (王金武) & Kerong Dai  (戴尅戎)

  3. Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

    Yuehua Liu  (刘月华)

  4. Hunan Polytechnic of Environment and Biology, Hengyang, Hunan, 422000, China

    Yeye Sun  (孙叶叶)

  5. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China

    Xiaojun Zhou  (周小军)

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  1. Wenhao Wang  (王文豪)
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  3. Tao Li  (李涛)
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  11. Jinwu Wang  (王金武)
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Correspondence to Jinwu Wang  (王金武) or Kerong Dai  (戴尅戎).

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Foundation item: the National Key Research and Development Program of China (No. 2018YFB1105600)

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Wang, W., Deng, Q., Li, T. et al. Research Update on Bioreactors Used in Tissue Engineering. J. Shanghai Jiaotong Univ. (Sci.) 26, 272–283 (2021). https://doi.org/10.1007/s12204-021-2293-5

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