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Three-dimensional phase contrast magnetic resonance imaging validated to assess pulmonary artery flow in patients with chronic thromboembolic pulmonary hypertension

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Abstract

In this study, three-dimensional phase contrast magnetic resonance imaging (3D-PC MRI), a novel technique, was validated to assess pulmonary artery (PA) flow in patients with chronic thromboembolic pulmonary hypertension (CTEPH). The MR data of PAs from 3D-PC and two-dimensional PC (2D-PC) from before and after treatment for 3 patients with CTEPH were retrospectively analyzed. Additionally, 3D- and 2D-PC MR scans of PA were performed in 5 healthy volunteers. Correlation of stroke volumes (SVs) obtained by 3D-PC and 2D-PC was analyzed using Pearson’s correlation coefficients. There was an excellent correlation in the SV of main PA, left PA and right PA between 3D-PC and 2D-PC (main PA: r = 0.91, p < 0.01, left PA: r = 0.72, p < 0.01 and right PA: r = 0.77, p < 0.01). In conclusion, 3D-PC MRI was able to accurately quantify the PA flow in patients with CTEPH.

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Acknowledgements

The authors state that this work has not received any funding and declare that they have no conflicts of interest. All procedures in studies involving human participants were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in this study.

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Authors and Affiliations

  1. Department of Radiological Technology, Faculty of Fukuoka Medical Technology, Teikyo University, 6-22 Misaki-machi, Omuta, Fukuoka, Japan

    Masateru Kawakubo

  2. Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan

    Hiroshi Akamine

  3. Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Hiroshi Akamine

  4. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Yuzo Yamasaki

  5. Philips Electronics Japan, Ltd, Tokyo, Japan

    Atsushi Takemura

  6. Department of Advanced Cardiovascular Regulation and Therapeutics, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan

    Kohtaro Abe

  7. Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan

    Kazuya Hosokawa

  8. Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan

    Junji Morishita

  9. Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University, Tokyo, Japan

    Michinobu Nagao

Authors
  1. Masateru Kawakubo
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  2. Hiroshi Akamine
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  3. Yuzo Yamasaki
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  4. Atsushi Takemura
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  5. Kohtaro Abe
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  6. Kazuya Hosokawa
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  7. Junji Morishita
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  8. Michinobu Nagao
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Correspondence to Masateru Kawakubo.

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All authors have no conflicts of interest to disclose.

Ethical approval

All procedures in studies involving human participants were performed in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in this study.

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Kawakubo, M., Akamine, H., Yamasaki, Y. et al. Three-dimensional phase contrast magnetic resonance imaging validated to assess pulmonary artery flow in patients with chronic thromboembolic pulmonary hypertension. Radiol Phys Technol 10, 249–255 (2017). https://doi.org/10.1007/s12194-016-0383-0

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  • DOI: https://doi.org/10.1007/s12194-016-0383-0

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