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The P5 disulfide switch: taming the aging unfolded protein response

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Fig. 1
Fig. 2
Fig. 3

Abbreviations

ATF:

Activating transcription factor

BiP:

Binding immunoglobulin protein

CHOP:

CCAAT-enhancer-binding protein homologous protein

ER:

Endoplasmic reticulum

ERAD:

ER-associated degradation

GADD:

Growth arrest and DNA-damage-inducible

GRP:

Glucose-regulated protein

IRE-1:

Inositol-requiring enzyme-1

NADPH:

Nicotinamide adenine dinucleotide phosphate

NOX:

NADPH oxidases

PDI:

Protein disulfide isomerase

PERK:

Protein kinase RNA-like endoplasmic reticulum kinase

QC:

Quality control

ROS:

Reactive oxygen species

UPR:

Unfolded protein response

XBP-1:

X-box binding protein-1

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Acknowledgments

This study was carried out with funding received from UNESCO and the China Scholarship Council under the guidelines of the UNESCO/Great Wall Fellowship Award 2013–14. I would like to thank Prof. Chih-Chen (Zhizhen) Wang, of the Chinese Academy of Sciences for hosting me in her group for the duration of this fellowship. Her encouragement and support were invaluable in writing this manuscript. I would also like to extend my gratitude to Dr. K.V. Sindhu, Dr. Wang Lei, and Dr. Wang Xi who took the time to discuss this idea with me, gave me valuable notes regarding the construction of this manuscript, and Mr. Akhil Mathew who illustrated Fig. 3 of this manuscript, as well as Dr. P. Allirani for her assistance in designing Fig. 1 of this manuscript.

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  1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15-Datun Road, Beijing, 100101, China

    Akash Mathew

  2. Department of Biochemistry, University of Delhi, South Campus, Benito Juarez marg, New Delhi, 110021, India

    Akash Mathew

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Mathew, A. The P5 disulfide switch: taming the aging unfolded protein response. Cell Stress and Chaperones 20, 743–751 (2015). https://doi.org/10.1007/s12192-015-0606-z

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