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Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?

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Cell Stress and Chaperones Aims and scope

Abstract

Several studies suggest that the response to various stressors differs between the sexes. We aimed to study serum HSP70 and levels of oxidized-LDL (ox-LDL) as markers of oxidative stress in men and women with type 2 diabetes. We quantified serum HSP70 and levels of ox-LDL in three cohorts; patients with newly diagnosed diabetes, patients with long-standing diabetes and normal controls. The cohort of patients with newly diagnosed diabetes was followed up for 3 months under glucose-lowering therapy with metformin. Our findings showed that serum HSP70 level was increased in women with long-standing diabetes in comparison with men. HSP70 did not decrease after glucose lowering therapy in women with newly diagnosed diabetes, but it did decrease in men. There was no significant difference on ox-LDL between men and women in any of the studied cohorts. It decreased significantly in the cohort of patients with newly diagnosed diabetes after treatment, regardless of sex. There was no significant correlation between HSP70 and ox-LDL in any of the studied cohorts except among normal women. We suggest that diabetes induces an immune response and impairs cellular defense mechanisms against oxidative stress more commonly in women with type 2 diabetes than in men.

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Authors and Affiliations

  1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran

    Manouchehr Nakhjavani, Afsaneh Morteza, Alireza Esteghamati, Omid Khalilzadeh, Fatemeh Esfahanian, Leyla Khajeali & Firouzeh Feiz

  2. Department of Community and Preventive Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Alipasha Meysamie

Authors
  1. Manouchehr Nakhjavani
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  2. Afsaneh Morteza
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  3. Alipasha Meysamie
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  4. Alireza Esteghamati
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  5. Omid Khalilzadeh
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  6. Fatemeh Esfahanian
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  7. Leyla Khajeali
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  8. Firouzeh Feiz
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Correspondence to Manouchehr Nakhjavani.

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Nakhjavani, M., Morteza, A., Meysamie, A. et al. Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?. Cell Stress and Chaperones 16, 195–201 (2011). https://doi.org/10.1007/s12192-010-0232-8

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  • DOI: https://doi.org/10.1007/s12192-010-0232-8

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