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IL-10 promoter polymorphism associated with decreased risk of aGvHD after stem cell transplantation: a meta-analysis

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Abstract

The bulk of evidences indicates that variations in the coding for cytokines or the regulation of their expression may play a role in acute graft-versus-host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT). It is unclear whether IL-10 promoter polymorphism is associated with the occurrence of aGvHD in allogeneic HSCT. A systematic search was performed in PubMed and Embase databases and 10 studies were identified for inclusion. Data were extracted and pooled ORs together with 95 % CIs were calculated. The pooled result indicated that −592A allele in recipient was significantly associated with reduced risk of moderate aGvHD in HSCT [OR = 0.41 (0.21, 0.79), P = 0.008, I 2 = 25 %]. The same pattern was also obtained from the −819T allele in recipient [OR = 0.38 (0.18, 0.79), P = 0.01, I 2 = 41 %]. Furthermore, we found a significant positive correlation between the −592AA homozygote and lower risk of severe aGvHD in HSCT [OR = 0.54 (0.34, 0.86), P = 0.01, I 2 = 29 %]. The similar result was gained from the −1082A allele in recipient and decreased risk of severe aGvHD [OR = 0.71 (0.52, 0.98), P = 0.04, I 2 = 19 %]. However, there was no significant association between −592A, −819T, or −1082A allele in donor and risk of aGvHD. This meta-analysis suggests that the IL-10 A allele or AA homozygote at −592, T allele at −819 and the A allele at −1082 are associated with reduced risk of aGvHD in allogeneic HSCT.

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Acknowledgments

The National Natural Science Foundation of China (Grant No. 81072440), NSFC-Guangdong Union Grant (Grant No. U0832003) and Hubei Province Natural Science Fund project (2012FFB03708) supported this work.

Conflict of interest

The authors declare no financial conflict of interest.

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Authors and Affiliations

  1. Department of Internal Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China

    Ping Zhu

  2. Department of Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China

    Li Xie

  3. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Yan Yang, Feili Gong & Min Fang

  4. Department of Immunology, Medical College of China Three Gorges University, Yichang, China

    Jiajun Wang

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  1. Ping Zhu
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Correspondence to Li Xie.

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12185_2013_1363_MOESM1_ESM.tif

Fig.S1. Flow chart of article selection for meta-analysis. IU = HLA-identical unrelated; IS = HLA-identical sibling; aGVHD = acute graft-versus-host disease; R = recipient; D = donor; n = number of eligible studies (TIFF 1033 kb)

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Zhu, P., Xie, L., Yang, Y. et al. IL-10 promoter polymorphism associated with decreased risk of aGvHD after stem cell transplantation: a meta-analysis. Int J Hematol 98, 102–111 (2013). https://doi.org/10.1007/s12185-013-1363-3

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  • DOI: https://doi.org/10.1007/s12185-013-1363-3

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