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Geschichte der Kontrastechokardiographie

History of contrast echocardiography

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Die Kardiologie Aims and scope

Zusammenfassung

Die Entwicklung der Kontrastechokardiographie erstreckt sich über mehr als 50 Jahre. Die Besonderheit der Ultraschallkontrastmittel besteht darin, dass nennenswerte Kontrasteffekte nur dann zu erzielen sind, wenn Mikrogasbläschen in der Injektionslösung vorhanden sind. Dazu mussten Kontrastmittel und spezifische echokardiographische Techniken entwickelt werden. Meilensteine waren die Zulassung von stabilen, i.v. applizierbaren Kontrastmitteln und die Verfügbarkeit von Harmonic Imaging und kontrastspezifischen Ultraschallmethoden auf den Echokardiographiegeräten. Die experimentelle und klinische Forschung wurde von deutschen Wissenschaftlern und Klinikern entscheidend mitgeprägt und hat zur weltweiten Etablierung der Kontrastechokardiographie in der klinischen Diagnostik beigetragen. Wesentliche Studien und die beteiligten Wissenschaftler und Kliniker werden vorgestellt. Die Translation der Studienergebnisse in die klinische Praxis findet sich in den Anweisungen zur Kontrastechokardiographie im Manual zur Indikation und Durchführung spezieller echokardiographischer Anwendungen von 2021 der AG Kardiovaskulärer Ultraschall der Deutschen Gesellschaft für Kardiologie (DGK).

Abstract

The development of contrast echocardiography spans over more than 50 years. Ultrasound contrast agents are unique because significant contrast effects can only be achieved when gas containing microbubbles are present in the injection solution. In addition to suitable contrast agents, specific echocardiographic techniques were developed. Milestones included the approval of stable, intravenously injectable contrast agents and the availability of harmonic imaging and contrast-specific ultrasound methods on the echocardiography devices. German scientists and clinicians were leaders or co-investigators in major experimental and clinical research projects, which led to the global establishment of contrast echocardiography for clinical diagnostics. The essential studies and the involved scientists and clinicians are presented. The translation of study results into clinical practice can be found in the instructions for contrast echocardiography in the manual for the indications and implementation of special echocardiographic applications from 2021 of the Cardiovascular Ultrasound Working Group of the German Cardiac Society (DGK).

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Notes

  1. Becher H. Persönliche Mitteilung.

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  1. St. Marien Hospital Lünen, Medizinische Klinik I, KLW St. Paulus GmbH, Altstadtstr. 23, 44534, Lünen, Deutschland

    Andreas Helfen

  2. Mazankowski Alberta Heart Institute, ABACUS, 0A8.32, University of Alberta Hospital, 8440-112 Street, T6G 2B7, Edmonton, Kanada

    Harald Becher

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Die Autoren weisen auf folgende Beziehungen hin. A. Helfen hat Honorare für Vorträge von Bracco Imaging Deutschland erhalten. H. Becher hat Honorare für die Beratung von Lantheus Imaging, Bracco Imaging, Schering, Philips erhalten, sowie Forschungsgelder von Schering, Bracco Imaging und Lantheus Imaging, sowie Honorare für workshops gesponsert von Philips, Toshiba, Schering, Bracco Imaging, Lantheus Imaging.

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Helfen, A., Becher, H. Geschichte der Kontrastechokardiographie. Kardiologie (2024). https://doi.org/10.1007/s12181-024-00681-0

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  • DOI: https://doi.org/10.1007/s12181-024-00681-0

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