Skip to main content
Log in

Contralateral Anterior Cruciate Ligament Injuries Following Index Reconstruction in the Pediatric Athlete

  • Hot Topics
  • Published:
Current Reviews in Musculoskeletal Medicine Aims and scope Submit manuscript

Abstract

Purpose of Review

The purpose of this review is to discuss relevant anatomy and pathoanatomy in the knee following anterior cruciate ligament reconstruction, risk factors for contralateral ACL tear, and mechanisms of contralateral injuries in the pediatric population.

Recent Findings

Contralateral ACL rupture rates following ACL reconstruction (ACLR) range from 4% to 42%. Pediatric patients show increased risk compared with adults, likely due to inherent anatomical differences along with biomechanical and neuromuscular changes that occur in both the operative and contralateral knees following index ACLR. Pediatric athletes who return to sport more quickly have been found to be at increased risk for contralateral tears, as have athletes who participate in cutting and pivoting sports. Contralateral tears tend to occur via non-contact mechanisms.

Summary

Pediatric patients are at increased risk of contralateral ACL injury following index ACL reconstruction compared with adults. Further study is warranted to determine appropriate biologic, functional, and rehabilitative parameters gauged toward preventing contralateral ACL tear while minimizing time lost from sport.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Hootman JM, Dick R, Agel J. Epidemiology of collegiate injuries for 15 sports: summary and recommendations for injury prevention initiatives. J Athl Train. 2007;42(02):311–9.

    PubMed  PubMed Central  Google Scholar 

  2. Dodwell ER, LaMont LE, Green DW, Pan TJ, Marx RG, Lyman S. 20 years of pediatric anterior cruciate ligament reconstruction in New York state. Am J Sports Med. 2014;42:675–80.

    Article  PubMed  Google Scholar 

  3. Mall NA, Chalmers PN, Moric M. Incidence and trends of anterior cruciate ligament reconstruction in the United States. Am J Sports Med. 2014;42(10):2363–70.

    Article  PubMed  Google Scholar 

  4. Werner BC, Yang S, Looney AM, Gwathmey FWJ. Trends in pediatric and adolescent anterior cruciate ligament injury and reconstruction. J Pediatr Orthop. 2016;36(5):447–52.

    Article  PubMed  Google Scholar 

  5. Anderson AF. Transepiphyseal replacement of the anterior cruciate ligament in skeletally immature patients. A preliminary report. J Bone Joint Surg Am. 2003;85-A:1255.

    Article  Google Scholar 

  6. Kocher MS, Saxon HS, Hovis WD, Hawkins RJ. Management and complications of anterior cruciate ligament injuries in skeletally immature patients: survey of the Herodicus Society and The ACL Study Group. J Pediatr Orthop. 2002;22(4):452–7.

    PubMed  Google Scholar 

  7. Mall et al. Pediatric ACL injuries: evaluation and management. Curr Rev Musculoskeletal Med. 2013.

  8. • Cordasco FA, Mayer SW, Green DW. All-inside, all-epiphyseal anterior cruciate ligament reconstruction in skeletally immature athletes: return to sport, incidence of second surgery, and 2-year clinical outcomes. Am J Sports Med. 2017;45:856–63 Case series suggesting targeted rehabilitation of over a year for contralateral strength and neuromuscular control deficiencies after ACLR to decrease instances of contralateral tear in pediatric athletes who have remaining growth.

    Article  PubMed  Google Scholar 

  9. Placella G, Bartoli M, Peruzzi M, Speziali A, Pace V, Cerulli G. Return to sport activity after anterior cruciate ligament reconstruction in skeletally immature athletes with manual drilling original all inside reconstruction at 8 years follow-up. Acta Orthop Traumatol Turc. 2016;50:635–8.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Andrish JT. Anterior cruciate ligament injuries in the skeletally immature patient. Am J Orthop. 2001;30:103–10.

    CAS  PubMed  Google Scholar 

  11. Webster KE, Feller JA, Kimp AJ, Whitehead TS. Revision anterior cruciate ligament reconstruction outcomes in younger patients: medial meniscal pathology and high rates of return to sport are associated with third ACL injuries. Am J Sports Med. 2018;46(5):1137–42.

    Article  PubMed  Google Scholar 

  12. Webster KE, Feller JA. Exploring the high reinjury rate in younger patients undergoing anterior cruciate ligament reconstruction. Am J Sports Med. 2016;44(11):2827–32.

    Article  PubMed  Google Scholar 

  13. •• Dekker TJ, Godin JA, Dale KM, Garrett WE, Taylor DC, Riboh JC. Return to sport after pediatric anterior cruciate ligament reconstruction and its effect on subsequent anterior cruciate ligament injury. J Bone Joint Surg Am. 2017;99(11):897–904 Cohort study finding that the only protective factor for contralateral tear in pediatric athletes is delayed return-to-sport, suggesting a role for timed biological recovery that is independent of strength and neuromuscular control benchmarks.

    Article  PubMed  Google Scholar 

  14. Swärd P, Kostogiannis I, Roos H. Risk factors for a contralateral anterior cruciate ligament injury. Knee Surg Sports Traumatol Arthrosc. 2010;18:277–91. https://doi.org/10.1007/s00167-009-1026-3.

    Article  PubMed  Google Scholar 

  15. Lohmander LS, Östenberg A, Englund M, Roos H. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum. 2004;50:3145–52. https://doi.org/10.1002/art.20589.

    Article  CAS  PubMed  Google Scholar 

  16. Frank CB, Jackson DW. The science of reconstruction of the anterior cruciate ligament. J Bone Joint Surg Am. 1997;79(10):1556–76.

    Article  CAS  PubMed  Google Scholar 

  17. Lohmander LS, Englund PM, Dahl LL, Roos EM. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med. 2007;35:1756–69.

    Article  PubMed  Google Scholar 

  18. Petersen W, Zantop T. Anatomy of the anterior cruciate ligament with regard to its two bundles. Clin Orthop Relat Res. 2007;454:35–47.

    Article  PubMed  Google Scholar 

  19. Kepler C, Potter H, Green DW, Hammoud S. Intercondylar notch dimensions and growth patterns in young pediatric patients. Presented at the Annual Meeting of the American Academy of Orthopedic Surgeons; 2011 Feb 16–19; San Diego, CA.

  20. Domzalski ME, Keller MS, Grzelak P, Gabos P. MRI evaluation of the development of the intercondylar notch width in children. Surg Radiol Anat. 2015;37:609–15. https://doi.org/10.1007/s00276-015-1433-8.

    Article  PubMed  Google Scholar 

  21. O’Malley, MP, Milewski MD, Solomitp MJ, Erwteman AS, Nissen CW. The association of tibial slope surgery 2015; 31(1) 7–82.

  22. Dare DM, Fabricant PD, McCarthy MM, Rebolledo BJ, Green DW, Cordasco FA, et al. Increased lateral tibial slope is a risk factor for pediatric anterior cruciate ligament injury. Am J Sports Med. 2015;43(7):1632–8. https://doi.org/10.1177/0363546515579182.

    Article  PubMed  Google Scholar 

  23. DeFrancesco CJ, Storey EP, Shea KG, et al. Challenges in the management of anterior cruciate ligament ruptures in skeletally immature patients. J Am Acad Orthop Surg. 2018;26(3):e50–61.

    Article  PubMed  Google Scholar 

  24. Dimeglio A: Growth in pediatri orthopaedics. In Morrissey RT WR (ed): Lovell and Winter's pediatric Orthopaedics. Philadelphia, PA, Lippincott, 2001, pp 33–63.

  25. Morgan MD, Salmon LJ, Waller A, Roe JP, Pinczewski LA. Fifteen-year survival of endoscopic anterior cruciate ligament reconstruction in patients aged 18 years and younger. Am J Sports Med. 2016;44(2):384–92.

    Article  PubMed  Google Scholar 

  26. Mosley CF. Leg length discrepancy. In: Morrissy RT, Weinstein SL, editors. Lovell and Winter’s Pediatric Orthopaedics. 5. Philadelphia: Lippincott Wiliams & Wilkins; 2001. p. 1111–27.

    Google Scholar 

  27. Anderson AF. Transepiphyseal replacement of the anterior cruciate ligament using quadruple hamstring grafts in skeletally immature patients. J Bone Joint Surg Am. 2004;86-A Suppl 1(Pt 2):201–9.

    Article  PubMed  Google Scholar 

  28. Kocher MS, Garg S, Micheli LJ. Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents. J Bone Joint Surg Am. 2005;87(11):2371–9.

    PubMed  Google Scholar 

  29. Feagin JA Jr, Curl WW. Isolated tear of the anterior cruciate ligament: 5-year follow-up study. Am J Sports Med. 1976;4(3):95–100.

    Article  PubMed  Google Scholar 

  30. Marshall JL, Warren RF, Wickiewicz TL, et al. The anterior cruciate ligament: a technique of repair and reconstruction. Clin Orthop Relat Res. 1979;143:97–106.

    Google Scholar 

  31. Strand T, Molster A, Hordvik M, et al. Long-term follow-up after primary repair of the anterior cruciate ligament: clinical and radiological evaluation 15-23 years postoperatively. Arch Orthop Trauma Surg. 2005;125(4):217–21.

    Article  CAS  PubMed  Google Scholar 

  32. DeLee JC, Curtis R. Anterior cruciate ligament insufficiency in children. Clin Orthop Relat Res. 1983;172:112–8.

    Google Scholar 

  33. DiFelice GS, Villegas C, Taylor S. Anterior cruciate ligament preservation: early results of a novel arthroscopic technique for suture anchor primary anterior cruciate ligament repair. Arthroscopy. 2015;31(11):2162–71.

    Article  PubMed  Google Scholar 

  34. van der List JP, DiFelice GS. Arthroscopic primary anterior cruciate ligament repair with suture augmentation. Arthrosc Tech. 2017;6(5):e1529–34.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Murray MM, Flutie BM, Kalish LA, Ecklund K, Fleming BC, Proffen BL, et al. The bridge-enhanced anterior cruciate ligament repair (BEAR) procedure: an early feasibility cohort study. Orthop J Sports Med. 2016;4(11):2325967116672176.

    PubMed  PubMed Central  Google Scholar 

  36. Murray MM, Kalish LA, Fleming BC, et al. Bridge-enhanced anterior cruciate ligament repair: two-year results of a first-in-human study. Orthop J Sports Med. 2019;7(3):2325967118824356.

    PubMed  PubMed Central  Google Scholar 

  37. Anderson AF, Anderson CN. Correlation of meniscal and articular cartilage injuries in children and adolescents with timing of anterior cruciate ligament reconstruction. Am J Sports Med. 2015;43:275–81.

    Article  PubMed  Google Scholar 

  38. Ramski DE, Kanj WW, Franklin CC, Baldwin KD, Ganley TJ. Anterior cruciate ligament tears in children and adolescents: a meta-analysis of nonoperative versus operative treatment. Am J Sports Med. 2014 Nov;42(11):2769–76.

    Article  PubMed  Google Scholar 

  39. Dumont GD, Hogue GD, Padalecki JR, Okoro N, Wilson PL. Meniscal and chondral injuries associated with pediatric anterior cruciate ligament tears: relationship of treatment time and patient-specific factors. Am J Sports Med. 2012 Sep;40(9):2128–33.

    Article  PubMed  Google Scholar 

  40. Kaeding CC, Flanigan D, Donaldson C. Surgical techniques and outcomes after anterior cruciate ligament reconstruction in preadolescent patients. Arthroscopy. 2010;26:1530–8. https://doi.org/10.1016/j.arthro.2010.04.065.

    Article  PubMed  Google Scholar 

  41. Frosch KH, Stengel D, Brodhun T, Stietencron I, Holsten D, Jung C, et al. Outcomes and risks of operative treatment of rupture of the anterior cruciate ligament in children and adolescents. Arthroscopy. 2010;26(11):1539–50.

    Article  PubMed  Google Scholar 

  42. Kercher J, Xerogeanes J, Tannenbaum A, al-Hakim R, Black JC, Zhao J. Anterior cruciate ligament reconstruction in the skeletally immature: an anatomical study utilizing 3-dimensional magnetic resonance imaging reconstructions. J Pediatr Orthop. 2009;29(2):124–9.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Lipscomb AB, Anderson AF. Tears of the anterior cruciate ligament in adolescents. J Bone Joint Surg Am. 1986;68(1):19–28.

    Article  CAS  PubMed  Google Scholar 

  44. Papageorgiou CD, Gil JE, Kanamori A, Fenwick JA, Woo SL, Fu FH. The biomechanical interdependence between the anterior cruciate ligament replacement graft and the medial meniscus. Am J Sports Med. 2001;29:226–31.

    Article  CAS  PubMed  Google Scholar 

  45. Gokeler A, Benjaminse A, van Eck CF, Webster KE, Schot L, Otten E. Return of normal gait as an outcome measurement in acl reconstructed patients. A systematic review. Int J Sports Phys Ther. 2013;8(4):441–51.

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Hart HF, Culvenor AG, Collins NJ, Ackland DC, Cowan SM, Machotka Z, et al. Knee kinematics and joint moments during gait following anterior cruciate ligament reconstruction: a systematic review and meta-analysis. Br J Sports Med. 2016 May;50(10):597–612.

    Article  PubMed  Google Scholar 

  47. •• Graziano J, Chiaia T, de Mille P, Nawabi DH, Green DW, Cordasco FA. Return to sport for skeletally immature athletes after ACL reconstruction: preventing a second injury using a quality of movement assessment and quantitative measures to address modifiable risk factors. Orthop J Sport Med. 2017;5:232596711770059 Clinical series with standardized return-to-sport criteria that suggests competitive pediatric athletes who return to noncontact cutting sports within 12 months are most at risk of contralateral injury and need to meet alignment and neuromuscular control benchmarks.

    Article  Google Scholar 

  48. Greenberg EM, Greenberg ET, Ganley TJ, Lawrence JTR. Strength and functional performance recovery after anterior cruciate ligament reconstruction in preadolescent athletes. Sports Health. 2014;6:309–12.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Nagelli CV, Hewett TE. Should return to sport be delayed until 2 years after anterior cruciate ligament reconstruction? Biological and functional considerations. Sports Med. 2017;47(2):221–32.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Roewer BD, Di Stasi SL, Snyder-Mackler L. Quadriceps strength and weight acceptance strategies continue to improve two years after anterior cruciate ligament reconstruction. J Biomech. 2011;44(10):1948–53.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Shelbourne KD, Gray T, Haro M. Incidence of subsquent injury to either knee within 5 years after anterior cruciate ligament reconstruction with patellar tendon autograft. Am J Sports Med. 2009;37(2):246–51.

    Article  PubMed  Google Scholar 

  52. Webster KE, Feller JA, Leigh WB, Richmond AK. Younger patients are at increased risk for graft rupture and contralateral injury after anterior cruciate ligament reconstruction. Am J Sports Med. 2014;42(3):641–7.

    Article  PubMed  Google Scholar 

  53. • Kay J, Memon M, Marx RG, Peterson D, Simunovic N, Ayeni OR. Over 90% of children and adolescents return to sport after anterior cruciate ligament reconstruction: a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2018;26(4):1019–36 Suggests an extremely high rate of return to sport after ACL reconstruction for pediatric patients, likely contributing to elevated rates of contralateral ACL tears that mirror rates of graft ruptures.

    Article  PubMed  Google Scholar 

  54. Pauzenberger L, Syre S, Shurz M. “Ligamentization” in hamstring tendon grafts after anterior cruciate ligament reconstruction: a systematic review of the literature and a glimpse into the future. Arthroscopy. 2013;29(10):1712–21.

    Article  PubMed  Google Scholar 

  55. Capin JJ, Khandha A, Zarzycki R, Manal K, Buchanan TS, Snyder-Mackler L. Gait mechanics and second ACL rupture: implications for delaying return-to-sport [published online 2016]. J Orthop Res. 2017. https://doi.org/10.1002/jor.23476.

  56. Arendt EA, Bershadsky B, Agel J. Periodicity of noncontact anterior cruciate ligament injuries during the menstrual cycle. J Gend Specif Med. 2002;5:19–26.

    PubMed  Google Scholar 

  57. Hewett TE, Myer GD, Ford KR. Biomechanical measures of neuromuscular control and valgus loading of the knee predict anterior cruciate ligament injury risk in female athletes: a prospective study. Am J Sports Med. 2005;33(4):492–501.

    Article  PubMed  Google Scholar 

  58. Hewett TE. Neuromuscular and hormonal factors associated with knee injuries in female athletes: strategies for intervention. Sports Med. 2000;29:313–27.

    Article  CAS  PubMed  Google Scholar 

  59. McLean SG, Lipfert S, van den Bogert AJ. Effect of gender and defensive opponent on the biomechanics of sidestep cutting. Med Sci Sports Exerc. 2004;36:1008–16.

    Article  PubMed  Google Scholar 

  60. Slauterbeck JR, Hardy DM. Sex hormones and knee ligament injuries in female athletes. Am J Med Sci. 2001;322:196–9.

    Article  CAS  PubMed  Google Scholar 

  61. Wojtys EM, Ashton-Miller JA, Huston LJ. A gender-related difference in the contribution of the knee musculature to sagittal-plane shear stiffness in subjects with similar knee laxity. J Bone Joint Surg Am. 2002;84:10–6.

    Article  PubMed  Google Scholar 

  62. Boden BP, Dean GS, Feagin JA, et al. Mechanisms of anterior cruciate ligament injury. Orthopedics. 2000;23:573–8.

    Article  CAS  PubMed  Google Scholar 

  63. Kobayashi H, Kanamura T, Koshida S, Miyashita K, Okado T, Shimizu T, et al. Mechanisms of the anterior cruciate ligament injury in sports activities: a twenty-year clinical research of 1,700 athletes. J Sports Sci Med. 2010;9(4):669–7.

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Derrick M. Knapik.

Ethics declarations

Conflict of Interest

Michael J. Salata, MD, is a paid consultant for Smith and Nephew, Stryker, and Linvatec, outside the current submission. James E. Voos, MD, is a paid consultant for Arthrex, outside the current submission.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gaal, B.T., Knapik, D.M., Karns, M.R. et al. Contralateral Anterior Cruciate Ligament Injuries Following Index Reconstruction in the Pediatric Athlete. Curr Rev Musculoskelet Med 13, 409–415 (2020). https://doi.org/10.1007/s12178-020-09652-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12178-020-09652-w

Keywords

Navigation