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Intrasubstance Anterior Cruciate Ligament Injuries in the Pediatric Population

  • Symposium - Pediatric Trauma
  • Published:
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Abstract

Pediatric intrasubstance anterior cruciate ligament (ACL) tears have a significant epidemiologic impact as their numbers continue to grow globally. This review focuses on true pediatric intrasubstance ACL tears, which occur >400,000 times annually. Modifiable and non-modifiable risk factors include intercondylar notch width, ACL size, gender, landing mechanisms, and hormonal variations. The proposed mechanisms of injury include anterior tibial shear and dynamic valgus collapse. ACL tears can be associated with soft tissue and chondral defects. History and physical examination are the most important parts of evaluation, including the Lachman test, which is considered the most accurate physical examination maneuver. Imaging studies should begin with AP and lateral radiographs, but magnetic resonance imaging is very useful in confirming the diagnosis and preoperative planning. ACL injury prevention programs targeting high risk populations have been proven to reduce the risk of injury, but lack uniformity across programs. Pediatric ACL injuries were conventionally treated nonoperatively, but recent data suggest that early operative intervention produces best long term outcomes pertaining to knee stability, meniscal tear risk, and return to previous level of play. Current techniques in ACL reconstruction, including more vertically oriented tunnels and physeal sparing techniques, have been described to reduce the risk of physeal arrest and limb angulation or deformity. Data consistently show that autograft is superior to allograft regarding failure rate. Mean durations of postoperative therapy and return to sport were 7 ± 3 and 10 ± 3 months, respectively. These patients have good functional outcomes compared to the general population yet are at increased risk of additional ACL injury. Attempts at primary ACL repair using biological scaffolds are under investigation.

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References

  1. Fabricant PD, Jones KJ, Delos D, Cordasco FA, Marx RG, Pearle AD, et al. Reconstruction of the anterior cruciate ligament in the skeletally immature athlete: A review of current concepts: AAOS exhibit selection. J Bone Joint Surg Am 2013;95:e28.

  2. Beck NA, Lawrence JT, Nordin JD, DeFor TA, Tompkins M. ACL tears in school-aged children and adolescents over 20 years. Pediatrics 2017;139. pii: e20161877.

  3. Nordenvall R, Bahmanyar S, Adami J, Stenros C, Wredmark T, Felländer-Tsai L, et al. A population-based nationwide study of cruciate ligament injury in Sweden, 2001–2009: Incidence, treatment, and sex differences. Am J Sports Med 2012;40:1808–13.

    Article  PubMed  Google Scholar 

  4. Gianotti SM, Marshall SW, Hume PA, Bunt L. Incidence of anterior cruciate ligament injury and other knee ligament injuries: A national population-based study. J Sci Med Sport 2009;12:622–7.

    Article  PubMed  Google Scholar 

  5. Griffin LY, Albohm MJ, Arendt EA, Bahr R, Beynnon BD, Demaio M, et al. Understanding and preventing noncontact anterior cruciate ligament injuries: A review of the hunt valley II meeting, January 2005. Am J Sports Med 2006;34:1512–32.

    Article  PubMed  Google Scholar 

  6. Renstrom P, Ljungqvist A, Arendt E, Beynnon B, Fukubayashi T, Garrett W, et al. Non-contact ACL injuries in female athletes: An International Olympic Committee current concepts statement. Br J Sports Med 2008;42:394–412.

    Article  PubMed  CAS  Google Scholar 

  7. Kaynak M, Nijman F, van Meurs J, Reijman M, Meuffels DE. Genetic variants and anterior cruciate ligament rupture: A systematic review. Sports Med 2017;47:1637–50.

    Article  PubMed  PubMed Central  Google Scholar 

  8. John R, Dhillon MS, Sharma S, Prabhakar S, Bhandari M. Is there a genetic predisposition to anterior cruciate ligament tear? A systematic review. Am J Sports Med 2016;44:3262–9.

    Article  PubMed  Google Scholar 

  9. Dodwell ER, Lamont LE, Green DW, Pan TJ, Marx RG, Lyman S, et al. 20 years of pediatric anterior cruciate ligament reconstruction in New York state. Am J Sports Med 2014;42:675–80.

    Article  PubMed  Google Scholar 

  10. Murray MM. Current status and potential of primary ACL repair. Clin Sports Med 2009;28:51–61.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kessler MA, Behrend H, Henz S, Stutz G, Rukavina A, Kuster MS, et al. Function, osteoarthritis and activity after ACL-rupture: 11 years followup results of conservative versus reconstructive treatment. Knee Surg Sports Traumatol Arthrosc 2008;16:442–8.

    Article  PubMed  CAS  Google Scholar 

  12. Meunier A, Odensten M, Good L. Long term results after primary repair or non-surgical treatment of anterior cruciate ligament rupture: A randomized study with a 15-year followup. Scand J Med Sci Sports 2007;17:230–7.

    PubMed  CAS  Google Scholar 

  13. Mather RC 3rd, Koenig L, Kocher MS, Dall TM, Gallo P, Scott DJ, et al. Societal and economic impact of anterior cruciate ligament tears. J Bone Joint Surg Am 2013;95:1751–9.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Anderson AF, Anderson CN. Correlation of meniscal and articular cartilage injuries in children and adolescents with timing of anterior cruciate ligament reconstruction. Am J Sports Med 2015;43:275–81.

    Article  PubMed  Google Scholar 

  15. Petersen W, Zantop T. Anatomy of the anterior cruciate ligament with regard to its two bundles. Clin Orthop Relat Res 2007;454:35–47.

    Article  PubMed  Google Scholar 

  16. Toy BJ, Yeasting RA, Morse DE, McCann P. Arterial supply to the human anterior cruciate ligament. J Athl Train 1995;30:149–52.

    PubMed  PubMed Central  CAS  Google Scholar 

  17. Schutte MJ, Dabezies EJ, Zimny ML, Happel LT. Neural anatomy of the human anterior cruciate ligament. J Bone Joint Surg Am 1987;69:243–7.

    Article  PubMed  CAS  Google Scholar 

  18. Boden BP, Dean GS, Feagin JA Jr., Garrett WE Jr. Mechanisms of anterior cruciate ligament injury. Orthopedics 2000;23:573–8.

    Article  PubMed  CAS  Google Scholar 

  19. Quatman CE, Hewett TE. The anterior cruciate ligament injury controversy: Is “valgus collapse” a sex-specific mechanism? Br J Sports Med 2009;43:328–35.

  20. Jaremko JL, Guenther ZD, Jans LB, Macmahon PJ. Spectrum of injuries associated with paediatric ACL tears: An MRI pictorial review. Insights Imaging 2013;4:273–85.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Millett PJ, Willis AA, Warren RF. Associated injuries in pediatric and adolescent anterior cruciate ligament tears: Does a delay in treatment increase the risk of meniscal tear? Arthroscopy 2002;18:955–9.

  22. Dumont GD, Hogue GD, Padalecki JR, Okoro N, Wilson PL. Meniscal and chondral injuries associated with pediatric anterior cruciate ligament tears: Relationship of treatment time and patient-specific factors. Am J Sports Med 2012;40:2128–33.

    Article  PubMed  Google Scholar 

  23. Pai DR, Strouse PJ. MRI of the pediatric knee. AJR Am J Roentgenol 2011;196:1019–27.

    Article  PubMed  Google Scholar 

  24. Papalia R, Torre G, Vasta S, Zampogna B, Pedersen DR, Denaro V, et al. Bone bruises in anterior cruciate ligament injured knee and long term outcomes. A review of the evidence. Open Access J Sports Med 2015;6:37–48.

    PubMed  PubMed Central  Google Scholar 

  25. Stevens KJ, Dragoo JL. Anterior cruciate ligament tears and associated injuries. Top Magn Reson Imaging 2006;17:347–62.

    Article  PubMed  Google Scholar 

  26. Hagino T, Ochiai S, Senga S, Yamashita T, Wako M, Ando T, et al. Meniscal tears associated with anterior cruciate ligament injury. Arch Orthop Trauma Surg 2015;135:1701–6.

    Article  PubMed  Google Scholar 

  27. Chhadia AM, Inacio MC, Maletis GB, Csintalan RP, Davis BR, Funahashi TT, et al. Are meniscus and cartilage injuries related to time to anterior cruciate ligament reconstruction? Am J Sports Med 2011;39:1894–9.

  28. Sankar WN, Wells L, Sennett BJ, Wiesel BB, Ganley TJ. Combined anterior cruciate ligament and medial collateral ligament injuries in adolescents. J Pediatr Orthop 2006;26:733–6.

    Article  PubMed  Google Scholar 

  29. Stanitski CL, Harvell JC, Fu F. Observations on acute knee hemarthrosis in children and adolescents. J Pediatr Orthop 1993;13:506–10.

    Article  PubMed  CAS  Google Scholar 

  30. Bach BR Jr., Warren RF, Wickiewicz TL. The pivot shift phenomenon: Results and description of a modified clinical test for anterior cruciate ligament insufficiency. Am J Sports Med 1988;16:571–6.

    Article  PubMed  Google Scholar 

  31. Gurtler RA, Stine R, Torg JS. Lachman test evaluated. Quantification of a clinical observation. Clin Orthop Relat Res 1987;216:141–50.

    Google Scholar 

  32. Benjaminse A, Gokeler A, van der Schans CP. Clinical diagnosis of an anterior cruciate ligament rupture: A meta-analysis. J Orthop Sports Phys Ther 2006;36:267–88.

    Article  PubMed  Google Scholar 

  33. Vaishya R, Hasija R. Joint hypermobility and anterior cruciate ligament injury. J Orthop Surg 2013;21(2):182–4.

  34. Anderson AF, Snyder RB, Federspiel CF, Lipscomb AB. Instrumented evaluation of knee laxity: A comparison of five arthrometers. Am J Sports Med 1992;20:135–40.

    Article  PubMed  CAS  Google Scholar 

  35. Rose NE, Gold SM. A comparison of accuracy between clinical examination and magnetic resonance imaging in the diagnosis of meniscal and anterior cruciate ligament tears. Arthroscopy 1996;12:398–405.

    Article  PubMed  CAS  Google Scholar 

  36. Taylor JB, Waxman JP, Richter SJ, Shultz SJ. Evaluation of the effectiveness of anterior cruciate ligament injury prevention programme training components: A systematic review and meta-analysis. Br J Sports Med 2015;49:79–87.

    Article  PubMed  Google Scholar 

  37. Yoo JH, Lim BO, Ha M, Lee SW, Oh SJ, Lee YS, et al. A meta-analysis of the effect of neuromuscular training on the prevention of the anterior cruciate ligament injury in female athletes. Knee Surg Sports Traumatol Arthrosc 2010;18:824–30.

    Article  PubMed  Google Scholar 

  38. Myer GD, Sugimoto D, Thomas S, Hewett TE. The influence of age on the effectiveness of neuromuscular training to reduce anterior cruciate ligament injury in female athletes: A meta-analysis. Am J Sports Med 2013;41:203–15.

    Article  PubMed  Google Scholar 

  39. Ramski DE, Kanj WW, Franklin CC, Baldwin KD, Ganley TJ. Anterior cruciate ligament tears in children and adolescents: A meta-analysis of nonoperative versus operative treatment. Am J Sports Med 2014;42:2769–76.

    Article  PubMed  Google Scholar 

  40. Samora WP 3rd, Palmer R, Klingele KE. Meniscal pathology associated with acute anterior cruciate ligament tears in patients with open physes. J Pediatr Orthop 2011;31:272–6.

    Article  PubMed  Google Scholar 

  41. Lawrence JT, Argawal N, Ganley TJ. Degeneration of the knee joint in skeletally immature patients with a diagnosis of an anterior cruciate ligament tear: Is there harm in delay of treatment? Am J Sports Med 2011;39:2582–7.

  42. Kaeding CC, Aros B, Pedroza A, Pifel E, Amendola A, Andrish JT, et al. Allograft versus autograft anterior cruciate ligament reconstruction: Predictors of failure from a MOON prospective longitudinal cohort. Sports Health 2011;3:73–81.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Mall NA, Paletta GA. Pediatric ACL injuries: Evaluation and management. Curr Rev Musculoskelet Med 2013;6:132–40.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Dekker TJ, Godin JA, Dale KM, Garrett WE, Taylor DC, Riboh JC, et al. Return to sport after pediatric anterior cruciate ligament reconstruction and its effect on subsequent anterior cruciate ligament injury. J Bone Joint Surg Am 2017;99:897–904.

    Article  PubMed  Google Scholar 

  45. Beynnon BD, Johnson RJ, Naud S, Fleming BC, Abate JA, Brattbakk B, et al. Accelerated versus nonaccelerated rehabilitation after anterior cruciate ligament reconstruction: A prospective, randomized, double-blind investigation evaluating knee joint laxity using roentgen stereophotogrammetric analysis. Am J Sports Med 2011;39:2536–48.

    Article  PubMed  Google Scholar 

  46. Andersson C, Gillquist J. Treatment of acute isolated and combined ruptures of the anterior cruciate ligament. A long term followup study. Am J Sports Med 1992;20:7–12.

    Article  PubMed  CAS  Google Scholar 

  47. Andersson C, Odensten M, Gillquist J. Knee function after surgical or nonsurgical treatment of acute rupture of the anterior cruciate ligament: A randomized study with a long term followup period. Clin Orthop Relat Res 1991;264:255–63.

    Google Scholar 

  48. Engström B, Gornitzka J, Johansson C, Wredmark T. Knee function after anterior cruciate ligament ruptures treated conservatively. Int Orthop 1993;17:208–13.

    Article  PubMed  Google Scholar 

  49. Cassard X, Cavaignac E, Maubisson L, Bowen M. Anterior cruciate ligament reconstruction in children with a quadrupled semitendinosus graft: Preliminary results with minimum 2 years of followup. J Pediatr Orthop 2014;34:70–7.

    Article  PubMed  Google Scholar 

  50. Longo UG, Ciuffreda M, Casciaro C, Mannering N, Candela V, Salvatore G, et al. Anterior cruciate ligament reconstruction in skeletally immature patients: A systematic review. Bone Joint J 2017;99-B: 1053–60.

  51. von Porat A, Roos EM, Roos H. High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: A study of radiographic and patient relevant outcomes. Ann Rheum Dis 2004;63:269–73.

    Article  Google Scholar 

  52. Murray MM, Fleming BC. Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery. Am J Sports Med 2013;41:1762–70.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Kiapour AM, Murray MM. Basic science of anterior cruciate ligament injury and repair. Bone Joint Res 2014;3:20–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  54. Robson AW. VI. Ruptured crucial ligaments and their repair by operation. Ann Surg 1903;37:716–8.

    PubMed  CAS  Google Scholar 

  55. O’Donoghue DH. Surgical treatment of fresh injuries to the major ligaments of the knee 1950. Clin Orthop Relat Res 2007;454:23–6.

    Article  PubMed  Google Scholar 

  56. Sandberg R, Balkfors B, Nilsson B, Westlin N. Operative versus nonoperative treatment of recent injuries to the ligaments of the knee. A prospective randomized study. J Bone Joint Surg Am 1987;69:1120–6.

    Article  PubMed  CAS  Google Scholar 

  57. Mastrangelo AN, Haus BM, Vavken P, Palmer MP, Machan JT, Murray MM, et al. Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res 2010;28:1100–6.

    PubMed  PubMed Central  Google Scholar 

  58. Nau T, Teuschl A. Regeneration of the anterior cruciate ligament: Current strategies in tissue engineering. World J Orthop 2015;6:127–36.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Nohara H, Kanaya F. Biomechanical study of adjacent intervertebral motion after lumbar spinal fusion and flexible stabilization using polyethylene-terephthalate bands. J Spinal Disord Tech 2004;17:215–9.

    Article  PubMed  Google Scholar 

  60. Anderson AF. Transepiphyseal replacement of the anterior cruciate ligament in skeletally immature patients. A preliminary report. Journal of Bone and Joint Surgery. 2003;85-A(7):1255–63.

  61. Guzzanti V, Falciglia F, Stanitski CL. Physeal-Sparing Intraarticular Anterior Cruciate Ligament Reconstruction in Preadolescents. American Journal of Sports Medicine. 2003;31(6):949–53.

  62. Cordasco FA, Mayer SW, Green DW. All-Inside, All-Epiphyseal Anterior Cruciate Ligament Reconstruction in Skeletally Immature Athletes: Return to Sport, Incidence of Second Surgery, and 2-Year Clinical Outcomes. American Journal of Sports Medicine. 2017;45(4):856–63.

  63. Wall EJ, Ghattas PJ, Eismann EA, Myer GD, Carr P. Outcomes and Complications After All-Epiphyseal Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients. Orthopaedic Journal of Sports Medicine. 2017; 5(3):2325967117693604.

  64. Kocher MS, Garg S, Micheli LJ. Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents: surgical technique. Journal of Bone and Joint Surgery. 2006;88:283–93.

    Article  Google Scholar 

  65. Bonnard C, Fournier J, Babusiaux D, Planchenault M, Bergerault F, de Courtivron B. Physeal-sparing reconstruction of anterior cruciate ligament tears in children: results of 57 cases using patellar tendon. Journal of Bone and Joint Surgery. 2011;93(4): 542–7.

  66. Koch PR Fucentese SF, Blatter SC. Complications after epiphyseal reconstruction of the anterior cruciate ligament in prepubescent children. Knee Surgery, Sports Traumatology, Arthroscopy. 2016;24(9):2736–40.

  67. McIntosh AL, Dahm DL, Stuart MJ. Anterior cruciate ligament reconstruction in the skeletally immature patient. Arthroscopy. 2006;22(12): 1325–30.

  68. Kocher MS, Smith JT, Zoric BJ, Lee B, Micheli LJ. Transphyseal anterior cruciate ligament reconstruction in skeletally immature pubescent adolescents. Journal of Bone and Joint Surgery. 2007;89(12):2632–9.

  69. Liddle AD, Imbuldeniya AM, Hunt DM. Transphyseal reconstruction of the anterior cruciate ligament in prepubescent children. Journal of Bone and Joint Surgery. 2008;90(10):1317–22.

  70. Courvoisier A, Grimaldi M, Plaweski S. Good surgical outcome of transphyseal ACL reconstruction in skeletally immature patients using four-strand hamstring graft. Knee Surgery, Sports Traumatology Arthroscopy. 2011;19(4):588–91.

  71. Kumar S, Ahearne D, Hunt DM. Transphyseal anterior cruciate ligament reconstruction in the skeletally immature: followup to a minimum of sixteen years of age. Journal of Bone and Joint Surgery. 2013;95(1):e1.

  72. Schmale GA, Kweon C, Larson RV, Bompadre V. High satisfaction yet decreased activity 4 years after transphyseal ACL reconstruction. Clinical Orthopaedics and Related Research. 2014;472(7):2168–74.

  73. Calvo R, Figueroa D, Gili F, Vaisman A, Mocoçain P, Espinosa M, León A, Arellano S. Transphyseal anterior cruciate ligament reconstruction in patients with open physes: 10-year follow-up study. American Journal of Sports Medicine. 2015:43(2):289–94.

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Correspondence to Khalid Hesham.

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Aylyarov, A., Tretiakov, M., Walker, S.E. et al. Intrasubstance Anterior Cruciate Ligament Injuries in the Pediatric Population. IJOO 52, 513–521 (2018). https://doi.org/10.4103/ortho.IJOrtho_381_17

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