Skip to main content

Advertisement

Log in

Return to sport after muscle injury

  • Muscle Injuries (SJ McNeill Ingham, Section Editor)
  • Published:
Current Reviews in Musculoskeletal Medicine Aims and scope Submit manuscript

Abstract

Skeletal muscle injuries are among the most common sports-related injuries that result in time lost from practice and competition. The cellular response to muscle injury can often result in changes made to the muscle fibers as well as the surrounding extracellular matrix during repair. This can negatively affect the force and range of the injured muscle even after the patient’s return to play. Diagnosis of skeletal muscle injury involves both history and physical examinations; imaging modalities including ultrasound and magnetic resonance imaging (MRI) can also be used to assess the extent of injury. Current research is investigating potential methods, including clinical factors and MRI, by which to predict a patient’s return to sports. Overall, function of acutely injured muscles seems to improve with time. Current treatment methods for skeletal muscle injuries include injections of steroids, anesthetics, and platelet-rich plasma (PRP). Other proposed methods involve inhibitors of key players in fibrotic pathways, such as transforming growth factor (TGF)-ß and angiotensin II, as well as muscle-derived stem cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Feeley BT, Kennelly S, Barnes RP, et al. Epidemiology of National Football League training camp injuries from 1998 to 2007. Am J Sports Med. 2008;36(8):1597–603.

    Article  PubMed  Google Scholar 

  2. Hallen A, Ekstrand J. Return to play following muscle injuries in professional footballers. J Sports Sci. 2014;32(13):1229–36. 12-year prospective cohort study on muscle injuries in professional soccer players. Hamstring injuries were found to be the most commonly injured muscle, and were associated with the longest time to return to play.

    Article  PubMed  Google Scholar 

  3. Cezar CA, Mooney DJ. Biomaterial-based delivery for skeletal muscle repair. Adv Drug Deliv Rev. Sep 28 2014.

  4. Agel J, Evans TA, Dick R, Putukian M, Marshall SW. Descriptive epidemiology of collegiate men’s soccer injuries: National Collegiate Athletic Association Injury Surveillance System, 1988–1989 through 2002–2003. J Athl Train. 2007;42(2):270–7.

    PubMed Central  PubMed  Google Scholar 

  5. Agel J, Olson DE, Dick R, Arendt EA, Marshall SW, Sikka RS. Descriptive epidemiology of collegiate women’s basketball injuries: National Collegiate Athletic Association Injury Surveillance System, 1988–1989 through 2003–2004. J Athl Train. 2007;42(2):202–10.

    PubMed Central  PubMed  Google Scholar 

  6. Dick R, Ferrara MS, Agel J, et al. Descriptive epidemiology of collegiate men’s football injuries: National Collegiate Athletic Association Injury Surveillance System, 1988–1989 through 2003–2004. J Athl Train. 2007;42(2):221–33.

    PubMed Central  PubMed  Google Scholar 

  7. Dick R, Hertel J, Agel J, Grossman J, Marshall SW. Descriptive epidemiology of collegiate men’s basketball injuries: National Collegiate Athletic Association Injury Surveillance System, 1988–1989 through 2003–2004. J Athl Train. 2007;42(2):194–201.

    PubMed Central  PubMed  Google Scholar 

  8. Morgan BE, Oberlander MA. An examination of injuries in major league soccer. The inaugural season. Am J Sports Med. 2001;29(4):426–30.

    CAS  PubMed  Google Scholar 

  9. Walden M, Hagglund M, Ekstrand J. UEFA Champions League study: a prospective study of injuries in professional football during the 2001–2002 season. Br J Sports Med. 2005;39(8):542–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Le Gall F, Carling C, Reilly T. Injuries in young elite female soccer players: an 8-season prospective study. Am J Sports Med. 2008;36(2):276–84.

    Article  PubMed  Google Scholar 

  11. Cross KM, Gurka KK, Saliba S, Conaway M, Hertel J. Comparison of hamstring strain injury rates between male and female intercollegiate soccer athletes. Am J Sports Med. 2013;41(4):742–8.

    Article  PubMed  Google Scholar 

  12. Ahmad CS, Dick RW, Snell E, et al. Major and minor league baseball hamstring injuries: epidemiologic findings from the major league baseball injury surveillance system. Am J Sports Med. 2014;42(6):1464–70.

    Article  PubMed  Google Scholar 

  13. Tidball JG. Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol. 2005;288(2):R345–353.

    Article  CAS  PubMed  Google Scholar 

  14. Karalaki M, Fili S, Philippou A, Koutsilieris M. Muscle regeneration: cellular and molecular events. In Vivo. 2009;23(5):779–96.

    CAS  PubMed  Google Scholar 

  15. Mantovani A, Sica A, Locati M. New vistas on macrophage differentiation and activation. Eur J Immunol. 2007;37(1):14–6.

    Article  CAS  PubMed  Google Scholar 

  16. Ciciliot S, Schiaffino S. Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implications. Curr Pharm Des. 2010;16(8):906–14.

    Article  CAS  PubMed  Google Scholar 

  17. Boppart MD, De Lisio M, Zou K, Huntsman HD. Defining a role for non-satellite stem cells in the regulation of muscle repair following exercise. Front Physiol. 2013;4:310.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Motohashi N, Asakura A. Muscle satellite cell heterogeneity and self-renewal. Front Cell Dev Biol. 2014;2:1.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Quintero AJ, Wright VJ, Fu FH, Huard J. Stem cells for the treatment of skeletal muscle injury. Clin Sports Med. 2009;28(1):1–11.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Gumucio JP, Flood MD, Phan AC, Brooks SV, Mendias CL. Targeted inhibition of TGF-beta results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury. J Appl Physiol (1985). 2013;115(4):539–45.

    Article  CAS  Google Scholar 

  21. Lieber RL, Ward SR. Cellular mechanisms of tissue fibrosis. 4. Structural and functional consequences of skeletal muscle fibrosis. Am J Physiol Cell Physiol. 2013;305(3):C241–252.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Heiderscheit BC, Sherry MA, Silder A, Chumanov ES, Thelen DG. Hamstring strain injuries: recommendations for diagnosis, rehabilitation, and injury prevention. J Orthop Sports Phys Ther. 2010;40(2):67–81.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Moen MH, Reurink G, Weir A, Tol JL, Maas M, Goudswaard GJ. Predicting return to play after hamstring injuries. Br J Sports Med. 2014;48(18):1358–63. doi:10.1136/bjsports-2014-093860.

  24. Kerkhoffs GM, van Es N, Wieldraaijer T, Sierevelt IN, Ekstrand J, van Dijk CN. Diagnosis and prognosis of acute hamstring injuries in athletes. Knee Surg, Sports Traumatol, Arthrosc: Off J ESSKA. 2013;21(2):500–9.

    Article  Google Scholar 

  25. Mueller-Wohlfahrt HW, Haensel L, Mithoefer K, et al. Terminology and classification of muscle injuries in sport: the Munich consensus statement. Br J Sports Med. 2013;47(6):342–50.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Malliaropoulos N, Papacostas E, Kiritsi O, Papalada A, Gougoulias N, Maffulli N. Posterior thigh muscle injuries in elite track and field athletes. Am J Sports Med. 2010;38(9):1813–9.

    Article  PubMed  Google Scholar 

  27. Clark BB, Jaffe D, Henn 3rd RF, Lovering RM. Evaluation and imaging of an untreated grade III hamstring tear: a case report. Clin Orthop Relat Res. 2011;469(11):3248–52.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Lee JC, Mitchell AW, Healy JC. Imaging of muscle injury in the elite athlete. Br J Radiol. 2012;85(1016):1173–85.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Jacobson J. Basic pathology concepts: muscle and tendon injuries. Fundamentals of musculoskeletal ultrasound . Vol 2nd edition 2013.

  30. Hayashi D, Hamilton B, Guermazi A, de Villiers R, Crema MD, Roemer FW. Traumatic injuries of thigh and calf muscles in athletes: role and clinical relevance of MR imaging and ultrasound. Insights Imaging. 2012;3(6):591–601.

    Article  PubMed Central  PubMed  Google Scholar 

  31. Martinoli CAS, Bignotti B, Tagliafico A. Imaging the skeletal muscle: when to use MR imaging and when to use ultrasound 2014. Book chapter that details optimal use of ultrasound and MRI. Ultrasound and MRI have equal sensitivity for diagnosing muscle strains, except in first few hours of injury, where ultrasound is less effective because new hemorrhage has a similar echogenicity as normal muscle tissue.

  32. McMillan AB, Shi D, Pratt SJ, Lovering RM. Diffusion tensor MRI to assess damage in healthy and dystrophic skeletal muscle after lengthening contractions. J Biomed Biotechnol. 2011;2011:970726.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Ekstrand J, Hagglund M, Walden M. Epidemiology of muscle injuries in professional football (soccer). Am J Sports Med. 2011;39(6):1226–32.

    Article  PubMed  Google Scholar 

  34. Peetrons P. Ultrasound of muscles. Eur Radiol. 2002;12(1):35–43.

    Article  CAS  PubMed  Google Scholar 

  35. Ekstrand J, Healy JC, Walden M, Lee JC, English B, Hagglund M. Hamstring muscle injuries in professional football: the correlation of MRI findings with return to play. Br J Sports Med. 2012;46(2):112–7.

    Article  PubMed  Google Scholar 

  36. Reurink G, Brilman EG, de Vos RJ, et al. Magnetic resonance imaging in acute hamstring injury: can we provide a return to play prognosis? Sports Med. Aug 15 2014. Systematic review of 12 studies evaluating MRI as a prognostic tool for return to play after acute muscle injury. The authors concluded that there is lack of strong evidence to use MRI as a tool to predict return to play due to high risk of bias. There is moderate evidence that injuries without hyperintensity on MRI are associated with shorter return to play time.

  37. Cloke D, Moore O, Shah T, Rushton S, Shirley MD, Deehan DJ. Thigh muscle injuries in youth soccer: predictors of recovery. Am J Sports Med. 2012;40(2):433–9.

    Article  PubMed  Google Scholar 

  38. Mendiguchia J, Samozino P, Martinez-Ruiz E, et al. Progression of mechanical properties during on-field sprint running after returning to sports from a hamstring muscle injury in soccer players. Int J Sports Med. 2014;35(8):690–5.

    Article  CAS  PubMed  Google Scholar 

  39. Delos D, Maak TG, Rodeo SA. Muscle injuries in athletes: enhancing recovery through scientific understanding and novel therapies. Sports Health. 2013;5(4):346–52.

    Article  PubMed Central  PubMed  Google Scholar 

  40. Levine WN, Bergfeld JA, Tessendorf W, Moorman 3rd CT. Intramuscular corticosteroid injection for hamstring injuries. A 13-year experience in the National Football League. Am J Sports Med. 2000;28(3):297–300.

    CAS  PubMed  Google Scholar 

  41. Stevens KJ, Crain JM, Akizuki KH, Beaulieu CF. Imaging and ultrasound-guided steroid injection of internal oblique muscle strains in baseball pitchers. Am J Sports Med. 2010;38(3):581–5.

    Article  PubMed  Google Scholar 

  42. Delos D, Leineweber MJ, Chaudhury S, Alzoobaee S, Gao Y, Rodeo SA. The effect of platelet-rich plasma on muscle contusion healing in a rat model. Am J Sports Med. 2014;42(9):2067–74.

    Article  PubMed  Google Scholar 

  43. Hammond JW, Hinton RY, Curl LA, Muriel JM, Lovering RM. Use of autologous platelet-rich plasma to treat muscle strain injuries. Am J Sports Med. 2009;37(6):1135–42.

    Article  PubMed Central  PubMed  Google Scholar 

  44. Gigante A, Del Torto M, Manzotti S, et al. Platelet rich fibrin matrix effects on skeletal muscle lesions: an experimental study. J Biol Regul Homeost Agents. 2012;26(3):475–84.

    CAS  PubMed  Google Scholar 

  45. Wright-Carpenter T, Opolon P, Appell HJ, Meijer H, Wehling P, Mir LM. Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model. Int J Sports Med. 2004;25(8):582–7.

    Article  CAS  PubMed  Google Scholar 

  46. Hamid MSA, Mohamed Ali MR, Yusof A, George J, Lee LP. Platelet-rich plasma injections for the treatment of hamstring injuries: a randomized controlled trial. Am J Sports Med. 2014;42(10):2410–8. doi:10.1177/0363546514541540.

  47. Bubnov R, Yevseenko V, Semeniv I. Ultrasound guided injections of platelets rich plasma for muscle injury in professional athletes. Comparative study. Med Ultrason. 2013;15(2):101–5.

    Article  PubMed  Google Scholar 

  48. Wright-Carpenter T, Klein P, Schaferhoff P, Appell HJ, Mir LM, Wehling P. Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains. Int J Sports Med. 2004;25(8):588–93.

    Article  CAS  PubMed  Google Scholar 

  49. Gharaibeh B, Chun-Lansinger Y, Hagen T, et al. Biological approaches to improve skeletal muscle healing after injury and disease. Birth Defects Res C Embryol Today. 2012;96(1):82–94.

    Article  CAS  Google Scholar 

  50. Fanbin M, Jianghai C, Juan L, et al. Role of transforming growth factor-beta1 in the process of fibrosis of denervated skeletal muscle. J Huazhong Univ Sci Technol Med Sci. 2011;31(1):77–82.

    Article  PubMed  Google Scholar 

  51. Burks TN, Cohn RD. Role of TGF-beta signaling in inherited and acquired myopathies. Skelet Muscle. 2011;1(1):19.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  52. Bedair HS, Karthikeyan T, Quintero A, Li Y, Huard J. Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle. Am J Sports Med. 2008;36(8):1548–54.

    Article  PubMed  Google Scholar 

  53. Chun Y, Ingham SJ, Irrgang J, et al. Improving recovery following recurrent hamstring injury using an angiotensin II receptor blocker: two case studies. 56th Orthopaedic Research Society. New Orleans, LA 2010.

  54. Terada S, Ota S, Kobayashi M, et al. Use of an antifibrotic agent improves the effect of platelet-rich plasma on muscle healing after injury. J bone Joint surg Am Vol. 2013;95(11):980–8.

    Article  Google Scholar 

  55. Torrente Y, Tremblay JP, Pisati F, et al. Intraarterial injection of muscle-derived CD34(+)Sca-1(+) stem cells restores dystrophin in mdx mice. J Cell Biol. 2001;152(2):335–48.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  56. Deasy BM, Lu A, Tebbets JC, et al. A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency. J Cell Biol. 2007;177(1):73–86.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  57. Ota S, Uehara K, Nozaki M, et al. Intramuscular transplantation of muscle-derived stem cells accelerates skeletal muscle healing after contusion injury via enhancement of angiogenesis. Am J Sports Med. 2011;39(9):1912–22.

    Article  PubMed  Google Scholar 

Download references

Compliance with Ethics Guidelines

Conflict of Interest

Stephanie Wong, Anne Ning, Carlin Lee, and Brian T. Feeley declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Brian T. Feeley.

Additional information

This article is part of the Topical Collection on Muscle Injuries

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wong, S., Ning, A., Lee, C. et al. Return to sport after muscle injury. Curr Rev Musculoskelet Med 8, 168–175 (2015). https://doi.org/10.1007/s12178-015-9262-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12178-015-9262-2

Keywords

Navigation