Skip to main content
SpringerLink
Log in

Automatically High-Throughput Quantification by Paper Spray Ionization Mass Spectrometry for Multiple Pesticides in Wine

  • Published:
Food Analytical Methods Aims and scope Submit manuscript

Abstract

A rapid paper spray (PS) ionization tandem mass spectrometry analytical method has been developed to determine multiple pesticides in red wine. Without chromatographic separation, 36 pesticides in wine could be simultaneously determined less than 9 and 3 min, followed by off-line QuEChERS treatment and on-line paper adsorption treatment, respectively. Isotopically labeled internal standard (IS) was utilized to calibrate injection process, and linear ranges were one to three orders of magnitude for different pesticides. LODs were ranging between 0.1 and 100 ng/mL, and LOQs were ranging between 0.3 and 300 ng/mL. Method validation was used to evaluate the accuracy and precision, and the results for most analytes were at the range of 75–120%. All the data processes were automatically achieved by build-in instrument software. These methods were also compared with QuEChERS-DART-MS/MS and DART-MS/MS. The results demonstrated that PS-MS/MS was a rapid and simple method to quantify multiple pesticides in red wine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Bridoux MC, Malandain H, Leprince F, Progent F, Machuron-Mandard X (2015) Quantitative analysis of phosphoric acid esters in aqueous samples by isotope dilution stir-bar sorptive extraction combined with direct analysis in real time (DART)-Orbitrap mass spectrometry. Anal Chim Acta 869:1–10

    Article  CAS  PubMed  Google Scholar 

  • Cajka T, Riddellova K, Zomer P, Mol H, Hajslova J (2011) Direct analysis of dithiocarbamate fungicides in fruit by ambient mass spectrometry. Food Addit Contam A 28:1372–1382

    Article  CAS  Google Scholar 

  • Carpinteiro I, Ramil M, Rodriguez I, Cela R (2010) Determination of fungicides in wine by mixed-mode solid phase extraction and liquid chromatography coupled to tandem mass spectrometry. J Chromatogr A 1217:7484–7492

    Article  CAS  PubMed  Google Scholar 

  • Codex Alimentarius Committee (CAC) (2018) Codex Pesticides Residues in Food Online Database. http://www.fao.org/fao-who-codexalimentarius/standards/pestres/en/

  • Cody RB, Laramee JA, Durst HD (2005) Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal Chem 77:2297–2302

    Article  CAS  PubMed  Google Scholar 

  • Crawford E, Musselman B (2012) Evaluating a direct swabbing method for screening pesticides on fruit and vegetable surfaces using direct analysis in real time (DART) coupled to an Exactive benchtop orbitrap mass spectrometer. Anal Bioanal Chem 403:2807–2812

    Article  CAS  PubMed  Google Scholar 

  • D'Agostino PA, Chenier CL, Hancock JR, Lepage CRJ (2007) Desorption electrospray ionisation mass spectrometric analysis of chemical warfare agents from solid-phase microextraction fibers. Rapid Commun Mass Spectrom 21:543–549

    Article  CAS  Google Scholar 

  • Edison SE, Lin LA, Gamble BM, Wong J, Zhang K (2011a) Surface swabbing technique for the rapid screening for pesticides using ambient pressure desorption ionization with high-resolution mass spectrometry. Rapid Commun Mass Spectrom 25:127–139

    Article  CAS  PubMed  Google Scholar 

  • Edison SE, Lin LA, Parrales L (2011b) Practical considerations for the rapid screening for pesticides using ambient pressure desorption ionisation with high-resolution mass spectrometry. Food Addit Contam A 28:1393–1404

    Article  CAS  Google Scholar 

  • Espy RD, Manicke NE, Ouyang Z, Cooks RG (2012) Rapid analysis of whole blood by paper spray mass spectrometry for point-of-care therapeutic drug monitoring. Analyst 137:2344–2349

    Article  CAS  PubMed  Google Scholar 

  • Evard H, Kruve A, Lohmus R, Leito I (2015) Paper spray ionization mass spectrometry: study of a method for fast-screening analysis of pesticides in fruits and vegetables. J Food Compos Anal 41:221–225

    Article  CAS  Google Scholar 

  • Garrett R, Rezende CM, Ifa DR (2013) Coffee origin discrimination by paper spray mass spectrometry and direct coffee spray analysis. Anal Methods UK 5:5944–5948

    Article  CAS  Google Scholar 

  • Gerbig S, Brunn HE, Spengler B, Schulz S (2015) Spatially resolved investigation of systemic and contact pesticides in plant material by desorption electrospray ionization mass spectrometry imaging (DESI-MSI). Anal Bioanal Chem 407:7379–7389

    Article  CAS  PubMed  Google Scholar 

  • Gerbig S, Stern G, Brunn HE, During RA, Spengler B, Schulz S (2017) Method development towards qualitative and semi-quantitative analysis of multiple pesticides from food surfaces and extracts by desorption electrospray ionization mass spectrometry as a preselective tool for food control. Anal Bioanal Chem 409:2107–2117

    Article  CAS  PubMed  Google Scholar 

  • Gomez-Rios GA, Gionfriddo E, Poole J, Pawliszyn J (2017) Ultrafast screening and quantitation of pesticides in food and environmental matrices by solid-phase microextraction-transmission mode (SPME-TM) and direct analysis in real time (DART). Anal Chem 89:7240–7248

    Article  CAS  PubMed  Google Scholar 

  • Guo TY, Fang PP, Jiang JJ, Zhang F, Yong W, Liu JH, Dong YY (2016) Rapid screening and quantification of residual pesticides and illegal adulterants in red wine by direct analysis in real time mass spectrometry. J Chromatogr A 1471:27–33

    Article  CAS  PubMed  Google Scholar 

  • Guo TY, Yong W, Jin Y, Zhang L, Liu J, Wang S, Chen Q, Dong Y, Su H, Tan T (2017a) Applications of DART-MS for food quality and safety assurance in food supply chain. Mass Spectrom Rev 36:161–187

    Article  CAS  PubMed  Google Scholar 

  • Guo TY, Zhang ZZ, Yannell KE, Dong YY, Cooks RG (2017b) Paper spray ionization mass spectrometry for rapid quantification of illegal beverage dyes. Anal Methods UK 9:6273–6279

    Article  CAS  Google Scholar 

  • Harper JD, Charipar NA, Mulligan CC, Zhang XR, Cooks RG, Ouyang Z (2008) Low-temperature plasma probe for ambient desorption ionization. Anal Chem 80:9097–9104

    Article  CAS  PubMed  Google Scholar 

  • International Union of Pure and Applied Chemistry (IUPAC) Gold Book (2018) https://goldbook.iupac.org/html/L/L03540.html

  • Ishibashi M, Izumi Y, Sakai M, Ando T, Fukusaki E, Bamba T (2015) High-throughput simultaneous analysis of pesticides by supercritical fluid chromatography coupled with high-resolution mass spectrometry. J Agric Food Chem 63:4457–4463

    Article  CAS  PubMed  Google Scholar 

  • Jeong ES, Kim KH, Cha E, Kwon OS, Cha S, Lee J (2016) Direct and rapid quantitation of ephedrines in human urine by paper spray ionization/high resolution mass spectrometry. J Chromatogr B 1028:237–241

    Article  CAS  Google Scholar 

  • Manicke NE, Bills BJ, Zhang CS (2016) Analysis of biofluids by paper spray MS: advances and challenges. Bioanalysis 8:589–606

    Article  CAS  PubMed  Google Scholar 

  • Mulligan CC, MacMillan DK, Noll RJ, Cooks RG (2007) Fast analysis of high-energy compounds and agricultural chemicals in water with desorption electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 21:3729–3736

    Article  CAS  PubMed  Google Scholar 

  • Na N, Zhang C, Zhao M, Zhang S, Yang C, Fang X, Zhang X (2007) Direct detection of explosives on solid surfaces by mass spectrometry with an ambient ion source based on dielectric barrier discharge. J Mass Spectrom 42:1079–1085. https://doi.org/10.1002/jms.1243

    Article  CAS  PubMed  Google Scholar 

  • Nanita SC, Kaldon LG (2016) Emerging flow injection mass spectrometry methods for high-throughput quantitative analysis. Anal Bioanal Chem 408:23–33

    Article  CAS  PubMed  Google Scholar 

  • Pelajic M, Pecek G, Pavlovic DM, Cepo DV (2016) Novel multiresidue method for determination of pesticides in red wine using gas chromatography-mass spectrometry and solid phase extraction. Food Chem 200:98–106

    Article  CAS  PubMed  Google Scholar 

  • Pertot I, Caffi T, Rossi V, Mugnai L, Hoffmann C, Grando MS, Gary C, Lafond D, Duso C, Thiery D, Mazzoni V, Anfora G (2017) A critical review of plant protection tools for reducing pesticide use on grapevine and new perspectives for the implementation of IPM in viticulture. Crop Prot 97:70–84

    Article  CAS  Google Scholar 

  • Pesticide action network (PAN) Europe. Message in a Bottle (2008). http://www.pan-europe.info/sites/pan-europe.info/files/public/resources/briefings/message-in-a-bottle.pdf

  • Reeber SL, Gadi S, Huang SB, Glish GL (2015) Direct analysis of herbicides by paper spray ionization mass spectrometry. Anal Methods UK 7:9808–9816

    Article  CAS  Google Scholar 

  • Rocca LM, Cecca J, L'Episcopo N, Fabrizi G (2017) Ambient mass spectrometry: direct analysis of dimethoate, tebuconazole, and trifloxystrobin on olive and vine leaves by desorption electrospray ionization interface. J Mass Spectrom 52:709–719

    Article  CAS  Google Scholar 

  • Schurek J, Vaclavik L, Hooijerink H(D), Lacina O, Poustka J, Sharman M, Caldow M, Nielen MWF, Hajslova J (2008) Control of Strobilurin fungicides in wheat using direct analysis in real time accurate time-of-flight and desorption electrospray ionization linear ion trap mass spectrometry. Anal Chem 80:9567–9575

    Article  CAS  PubMed  Google Scholar 

  • Schwarz T, Snow TA, Santee CJ, Mulligan CC, Class T, Wadsley MP, Nanita SC (2011) QuEChERS multiresidue method validation and mass spectrometric assessment for the novel anthranilic diamide insecticides Chlorantraniliprole and Cyantraniliprole. J Agric Food Chem 59:814–821

    Article  CAS  PubMed  Google Scholar 

  • Standardization Administration of China (SAC) (2018). National Food Safety Standard – Maximum Residue Limits for Pesticides in Food (GB 2763–2016). http://down.foodmate.net/standard/sort/3/40372.html

  • Takats Z, Wiseman JM, Gologan B, Cooks RG (2004) Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306:471–473

    Article  CAS  PubMed  Google Scholar 

  • United States Department of Agriculture (USDA). Maximum Residue Limits (MRL) Database. https://www.fas.usda.gov/maximum-residue-limits-mrl-database. 2018

  • Wang H, Liu JJ, Cooks RG, Ouyang Z (2010) Paper spray for direct analysis of complex mixtures using mass spectrometry. Angew Chem Int Ed 49:877–880

    Article  CAS  Google Scholar 

  • Yannell KE, Kesely KR, Chien HD, Kissinger CB, Cooks RG (2017) Comparison of paper spray mass spectrometry analysis of dried blood spots from devices used for in-field collection of clinical samples. Anal Bioanal Chem 409:121–131

    Article  CAS  PubMed  Google Scholar 

  • Yong W, Guo TY, Fang PP, Liu JH, Dong YY, Zhang F (2017) Direct determination of multi-pesticides in wine by ambient mass spectrometry. Int J Mass Spectrom 417:53–57

    Article  CAS  Google Scholar 

  • Zhu XQ, Huang Z, Gao W, Li X, Li L, Zhu H, Mo T, Huang B, Zhou Z (2016) Rapid microcystin determination using a paper spray ionization method with a time-of-flight mass spectrometry system. J Agric Food Chem 64:5614–5619

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Authors wish to thank the support of Tianyang Guo through the CSC Scholarship Program from BUCT.

Authors are also grateful to R. Graham Cooks, Karen E. Yannell, Qiang Ma, Fan Pu, and Pingping Fang for helpful advice.

Funding

This study was funded by the National Key R&D Program of China (2016YFF0203703), the Key Program of a Synchronized Detection Research and Risk Assessment for Radionuclides in Foods of Beijing Municipal Science & Technology Commission (D161100002116002), and NSFC grant (51673012).

Author information

Authors and Affiliations

  1. Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Technology and Business University, Beijing, 100048, China

    Tianyang Guo

  2. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China

    Tianyang Guo & Yiyang Dong

  3. Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing, 100176, China

    Wei Yong

Authors
  1. Tianyang Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wei Yong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yiyang Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yiyang Dong.

Ethics declarations

Conflict of Interest

Tianyang Guo declares that she has no conflict of interest. Wei Yong declares that he has no conflict of interest. Yiyang Dong declares that he has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals.

Informed Consent

Not applicable.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic Supplementary Material

ESM 1

(DOCX 31 kb)

ESM 2

(DOCX 32 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guo, T., Yong, W. & Dong, Y. Automatically High-Throughput Quantification by Paper Spray Ionization Mass Spectrometry for Multiple Pesticides in Wine. Food Anal. Methods 12, 1208–1217 (2019). https://doi.org/10.1007/s12161-019-01450-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12161-019-01450-6

Keywords

Search

Navigation