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Methodology Studies on Detection of Aminoglycoside Residues

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Abstract

Aminoglycosides are a class of antibiotics commonly used in animal husbandry. If the antibiotics cannot be used legitimately, they would remain in animal foods and environment, even causing damage to human health. The effective detection to these residues is an important part of the protection of human health. In this review, the methodology studies about the detection of aminoglycoside residues are summarized for the related researchers to conveniently understand the progress of this field. These methodology studies involve multi-residue and single residue detection methods. The former includes high-performance liquid chromatography, liquid chromatography–mass spectrometry, and capillary electrophoresis, which are about 40 % of the literature we can access to. Developing the new fluorescent probe is a possible direction for these studies. The latter is about 50 % of the amount of literature, in which most are various immunoassays. The development of highly selective antibodies or aptamers is a possible direction for these assays. Since aminoglycosides have no useful absorption, their derivatization becomes an important part of the sample pretreatment. The presentations related to derivatization are about 30 % of the listed literature, and most of the rest are the purification of the samples. The development of solid-phase extraction adsorbent material which is high selectivity to this class of antibiotics and can be used repeatedly is a possible development direction.

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Acknowledgments

This work is supported by Specialized Research Fund for the Doctoral Program of Higher Education, Ministry of Education, China, (Grant No. 20093227110010) and The Science Fund of Jiangsu University (Grant No. 08JDG001).

Conflict of Interest

Guan-Hua Chen declares that he has no any financial/commercial conflicts of interest in this manuscript. Yi-Fang Tian declares that she has no any financial/commercial conflicts of interest in this manuscript. Li-Hui Guo declares that he has no any financial/commercial conflicts of interest in this manuscript. Xin Guo declares that she has no any financial/commercial conflicts of interest in this manuscript. Xiao-Yun Mei declares that she has no any financial/commercial conflicts of interest in this manuscript. This article does not contain any studies with human or animal subjects.

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  1. College of Food and Bioengineering, Jiangsu University, Zhenjiang, 212013, China

    Yi-Fang Tian, Guan-Hua Chen, Li-Hui Guo, Xin Guo & Xiao-Yun Mei

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Tian, YF., Chen, GH., Guo, LH. et al. Methodology Studies on Detection of Aminoglycoside Residues. Food Anal. Methods 8, 1842–1857 (2015). https://doi.org/10.1007/s12161-014-0067-5

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