Guenther, M. 2018. Wie wir Götter werden. Frankfurter Allgemeine Sonntagszeitung, No 19: 3, 12.05.2018.
Mueller, O., and S. Rotter. 2017. Neurotechnology: Current developments and ethical issues. Frontiers Systems Neuroscience 11: 00093.
Google Scholar
Merkel, R., G. Boer, J. Fegert, T. Galert, D. Hartmann, B. Nuttin, and S. Rosahl. 2007. Intervening in the brain. Berlin: Springer-Verlag.
Beauchamp, T.L., and J.F. Childress. 2013. Principles of biomedical ethics. 7th ed. New York: Oxford University Press.
Google Scholar
Clausen, J. 2009. Man, machine and in between. Nature 457: 1080–1081.
Google Scholar
Clausen, J., E. Fetz, J. Donoghue, J. Ushiba, U. Spörhase, J. Chandler, N. Birbaumer, and S.R. Soekadar. 2017. Help, hope, and hype: Ethical dimensions of neuroprosthetics. Science 356 (6345): 1338–1339.
Google Scholar
IEEE, Code of Ethics 2018. https://www.ieee.org/about/compliance.html ; last access: 2018-08-01.
Yuste, R., S. Goering, Blaise Agüera y Arcas, G. Bi, J.M. Carmena, A. Carter, J.J. Fins, P. Friesen, J. Gallant, J.E. Huggins, J. Illes, P. Kellmeyer, E. Klein, A. Marblestone, C. Mitchell, E. Parens, M. Pham, A. Rubel, N. Sadato, L. Specker Sullivan, M. Teicher, D. Wasserman, A. Wexler, M. Whittaker, and J. Wolpaw. 2017. Four ethical priorities for neurotechnologies and AI. Nature 551: 159–163.
Google Scholar
DiLuca, M., and J. Olesen. 2014. The cost of brain diseases: A burden or a challenge. Neuron 82 (6): 1205–1208.
Google Scholar
Famm, K., B. Litt, K.J. Tracey, E.S. Boyden, and M. Slaoui. 2013. A jump-start for electroceuticals. Nature 496: 159–161.
Google Scholar
Bouton, C. 2017. Cracking the neural code, treating paralysis and the future of bioelectronic medicine. Journal of Internal Medicine 282 (1): 37–45.
Google Scholar
Lenarz, T. 2018. Cochlear implant - state of the art. GMS Curr Top Otorhinolaryngol Head Neck Surg 16: cto000143.
NIDCD, NIH 2018. https://www.nidcd.nih.gov/health/cochlear-implants, last access: 2018-04-20.
Edwards, C.A., A. Kouzani, K.H. Lee, and E.K. Ross. 2017. Neurostimulation devices for the treatment of neurologic disorders. Mayo Clinic Proceedings 92 (9): 1427–1444.
Google Scholar
Brook, A.L., B.A. Georgy, and W.J. Olan. 2009. Spinal cord stimulation: A basic approach. Techniques in Vascular and Interventional Radiology 12: 64–70.
Google Scholar
Rijkhoff, N.J.M. 2004. Neuroprostheses to treat neurogenic bladder dysfunction: Current status and future perspectives. Child's Nervous System 20: 75–86.
Google Scholar
Lavelle, J.P., S. Teahan, D.Y. Kim, and M.B. Chancellor. 1999. Medical and minimally invasive treatment of urinary incontinence. Revista de Urología 1 (2): 111–120.
Google Scholar
Hatton, K.W., J.T. McLarney, T. Pittman, and B.G. Fahy. 2006. Vagal nerve stimulation: Overview and implications for anesthesiologists. Anesthesia and Analgesia 103 (5): 1241–1249.
Google Scholar
Groves, D.A., and V.J. Brown. 2005. Vagal nerve stimulation: A review of its applications and potential mechanisms that mediate its clinical effects. Neuroscience and Biobehavioral Reviews 29 (3): 493–500.
Google Scholar
Sobocki, J., G. Krolczyk, R.M. Herman, et al. 2005. Influence of vagal nerve stimulation on food intake and body weight – Results of experimental studies. Journal of Physiology and Pharmacology 56 (Suppl 6): 27–33.
Google Scholar
Plachta, D.T.T., M. Gierthmuehlen, O. Cota, N. Espinosa, F. Boeser, T.C. Herrera, T. Stieglitz, and J. Zentner. 2014. Blood pressure control with selective vagal nerve stimulation and minimal side effects. Journal of Neural Engineering 11 (3): 036011.
Google Scholar
Kiss, Z.H. 2009. Clinical and experimental aspects of deep brain stimulation. Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society: 2371–2374.
Albert, G.C., C.M. Cook, F.S. Prato, and A.W. Thomas. 2009. Deep brain stimulation, vagal nerve stimulation and transcranial stimulation: An overview of stimulation parameters and neurotransmitter release. Neuroscience and Biobehavioral Reviews 33 (7): 1042–1060.
Google Scholar
Coffey, R.J. 2009. Deep brain stimulation devices: A brief technical history and review. Artificial Organs 33 (3): 208–220.
Google Scholar
Perlmutter, J.S., and J.W. Mink. 2006. Deep brain stimulation. Annual Review of Neuroscience 29: 229–257.
Google Scholar
Stieglitz, T., and J.-U. Meyer. 2006. Neural implants in clinical practice. In Biomems, ed. G.A. Urban, 41–70. Dordrecht: Springer.
Google Scholar
Stieglitz, T., and J.-U. Meyer. 2006. Biomedical microdevices for neural implants. In Biomems, ed. G.A. Urban, 71–138. Dordrecht: Springer.
Google Scholar
Williams, D.F. 2018. On the mechanisms of biocompatibility. Biomaterials 29: 2941–2953.
Google Scholar
Medical Device Regulation (2017/745/EC), https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32017R0745. last access: 2018-08-01.
ISO 10993: International standard organization, ISO 10993: Biological evaluation of medical devices.
Erhardt, J.B., E. Fuhrer, O.G. Gruschke, J. Leupold, M.C. Wapler, J. Hennig, T. Stieglitz, and J.G. Korvink. 2018. Should patients with brain implants undergo MRI? Journal of Neural Engineering 15 (04): 041002.
Google Scholar
Alt, M.T., E. Fiedler, L. Rudmann, J.S. Ordonez, P. Ruther, and T. Stieglitz. 2017. Let there be light – Optoprobes for neural implants. Proceedings of the IEEE 105 (1): 101–138.
Google Scholar
Rudmann, L., M.T. Alt, D. Ashouri Vajari, and T. Stieglitz. 2018. Integrated optoelectronic microprobes. Current Opinion in Neurobiology 50: 72–82.
Google Scholar
Schuettler, M., and T. Stieglitz. 2013. Assembly and packaging. In Intelligent implantable sensor Systems for Medical Applications, ed. D. Hodgins and A. Inmann, 108–149. Cambridge: Woodhead Publishing Ltd.
Google Scholar
Kohler, F., C.A. Gkogkidis, C. Bentler, X. Wang, M. Gierthmuehlen, J. Fischer, C. Stolle, L.M. Reindl, J. Rickert, T. Stieglitz, T. Ball, and M. Schuettler. 2017. Closed-loop interaction with the cerebral cortex: A review of wireless implant technology. Brain-Computer Interfaces 4 (3): 146–154.
Google Scholar
Wise, K.D., D.J. Anderson, J.F. Hetke, D.R. Kipke, and K. Najafi. 2004. Wireless implantable microsystems: High- denisity electronic interfaces to the nervous system. Proceedings of the IEEE 92: 76–96.
Google Scholar
Zhao, H., F. Dehkhoda, R. Ramezani, D. Sokolov, P. Degenaar, Y. Liu, and T. Constandinou. 2015. A CMOS-based neural implantable optrode for optogenetic stimulation and electrical recording. Proc. IEEE biomedical circuits and systems conference (BioCAS), 1–4. Piscataway: IEEE.
Google Scholar
Hassler, C., T. Boretius, and T. Stieglitz. 2011. Polymers for neural implants. Journal of Polymer Science Part B: Polymer Physics 49 (1): 18–33.
Google Scholar
Ordonez, J., M. Schuettler, C. Boehler, T. Boretius, and T. Stieglitz. 2012. Thin films and microelectrode arrays for neuroprosthetics. MRS Bulletin 37 (06): 590–598.
Google Scholar
Mueller, M., N. de la Oliva, J. del Valle, I. Delgado-Martínez, X. Navarro, and T. Stieglitz. 2017. Rapid prototyping of flexible intrafascicular electrode arrays by picosecond laser structuring. Journal of Neural Engineering 14 (6): 66016.
Google Scholar
Gwon, T.M., C. Kim, S. Shin, J.H. Park, J.H. Kim, and S.J. Kim. 2016. Liquid crystal polymer (LCP)-based neural prosthetic devices. Biomedical Engineering Letters 6 (3): 148–163.
Google Scholar
Zijlmans, M., G.A. Worrell, M. Dümpelmann, T. Stieglitz, A. Barborica, M. Heers, A. Ikeda, N. Usui, and M. le van Quyen. 2017. How to record high-frequency oscillations in epilepsy. A practical guideline. Epilepsia 58 (8): 1305–1315.
Google Scholar
Fu, T.-M., G. Hong, R.D. Viveros, T. Zhou, and C.M. Lieber. 2017. Highly scalable multichannel mesh electronics for stable chronic brain electrophysiology. Proceedings of the National Academy of Sciences 114 (47): E10046–E10055.
Google Scholar
Traeger, R. 1977. Nonhermeticity of polymeric lid sealants. IEEE Transactions on Parts Hybrids and Packaging 13 (2): 147–152.
Google Scholar
Stieglitz, T. 2010. Manufacturing, assembling and packaging of miniaturized neural implants. Microsystem Technologies 16 (5): 723–734.
Google Scholar
Rupp, R., and H.J. Gerner. 2004. Neuroprosthetics of the upper extremity--clinical application in spinal cord injury and future perspectives. Biomedizinische Technik. Biomedical Engineering 49 (4): 93–98.
Google Scholar
Guiraud, D., T. Stieglitz, K.P. Koch, J.L. Divoux, and P. Rabischong. 2006. An implantable Neuroprostheses for standing and walking in paraplegia: 5 year patient follow up. Journal of Neural Engineering 3 (4): 268–275.
Google Scholar
Cogan, S.F. 2008. Neural stimulation and recording electrodes. Annual Review of Biomedical Engineering 10: 275–309.
Google Scholar
Stieglitz, T., T. Boretius, P. Čvančara, D. Guiraud, T. Guiho, V. M. Lopez-Alvarez, and X. Navarro 2016. On Biocompatibility and Stability of Transversal Intrafascicular Multichannel Electrodes—TIME. In J. Ibáñez, J. González-Vargas, J. M. Azorín, M. Akay, J. L. Pons (eds.) Converging Clinical and Engineering Research on Neurorehabilitation II. Proceedings of the 3rd International Conference on NeuroRehabilitation (ICNR2016), October 18–21, 2016, 731–735. Segovia: Springer International Publishing.
Barrese, J.C., J. Aceros, and J.P. Donoghue. 2016. Scanning electron microscopy of chronically implanted intracortical microelectrode arrays in non-human primates. Journal of Neural Engineering 13 (2): 026003.
Google Scholar
Barrese, J.C., N. Rao, K. Paroo, C. Triebwasser, C. Vargas-Irwin, L. Franquemont, and J.P. Donoghue. 2013. Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates. Journal of Neural Engineering 10 (6): 066014.
Google Scholar
Kampasi, K., E. Stark, J. Seymour, K. Na, H.G. Winful, G. Buzsáki, K.D. Wise, and E. Yoon. 2016. Fiberless multicolor neural optoelectrode for in vivo circuit analysis. Scientific Reports 6: 30961.
Google Scholar
Boehler, C., and M. Asplund. 2015. A detailed insight into drug delivery from PEDOT based on analytical methods. Effects and side effects. Journal of Biomedical Materials Research Part A 103 (3): 1200–1207.
Google Scholar
Chamanzar, M., D.J. Denman, T.J. Blanche, M.M. Maharbiz 2015. Ultracompact optoflex neural probes for high-resolution electrophysiology and optogenetic stimulation. Proc. of the 28th IEEE Int. Conf. on Micro Electro Mechanical Systems (MEMS). Piscataway, NJ: IEEE: 682–685.
Khodagholy, D., J.N. Gelinas, Z. Zhao, Y. Zifang, M. Yeh, M. Long, J.D. Greenlee, et al. 2016. Organic electronics for high-resolution electrocorticography of the human brain. Science Advances 2 (11): e1601027.
Google Scholar
Patel, P.R., H. Zhang, M.T. Robbins, J.B. Nofar, S.P. Marshall, M.J. Kobylarek, T.D.Y. Kozai, N.A. Kotov, and C.A. Chestek. 2016. Chronic in vivo stability assessment of carbon fiber microelectrode arrays. Journal of Neural Engineering 13 (6): 66002.
Google Scholar
Guitchounts, G., J.E. Markowitz, W.A. Liberti, and T. Gardner. 2013. A carbon-fiber electrode array for long-term neural recording. Journal of Neural Engineering 10 (4): 46016.
Google Scholar
Vomero, M., E. Castagnola, F. Ciarpella, E. Maggiolini, N. Goshi, E. Zucchini, S. Carli, L. Fadiga, S. Kassegne, and D. Ricci. 2017a. Highly stable glassy carbon interfaces for Long-term neural stimulation and low-noise recording of brain activity. Scientific Reports 7: 40332.
Google Scholar
Vomero, M., E. Castagnola, J.S. Ordonez, S. Carli, E. Zucchini, E. Maggiolini, et al. 2017b. Incorporation of silicon carbide and diamond-like carbon as adhesion promoters improves in vitro and in vivo stability of thin-film glassy carbon Electrocorticography arrays. Adv Biosys 10 (1700081).
Hochberg, L.R., M.D. Serruya, G.M. Friehs, et al. 2006. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442: 164–171.
Google Scholar
Tan, D.W., M.A. Schiefer, M.W. Keith, J.R. Anderson, J. Tyler, and D.J. Tyler. 2014. A neural interface provides long-term stable natural touch perception. Science Translational Medicine 6: 257ra138–257ra138.
Google Scholar
Raspopovic, S., M. Capogrosso, F.M. Petrini, M. Bonizzato, J. Rigosa, G.D. Pino, J. Carpaneto, M. Controzzi, T. Boretius, E. Fernandez, G. Granata, C.M. Oddo, L. Citi, A.L. Ciancio, C. Cipriani, M.C. Carrozza, W. Jensen, E. Guglielmelli, T. Stieglitz, P.M. Rossini, and S. Micera. 2014. Restoring natural sensory feedback in real-time bidirectional hand prostheses. Science Translational Medicine 6 (22): 222ra19.
Google Scholar
ICNIRP 2018: International Commission on Non-Ionizing Radiation Protection; https://www.icnirp.org/en/home/index.html; last access: 2018-08-01.
Obermeyer, Z., and E.J. Emanuel. 2016. Predicting the future — Big data, machine learning, and clinical medicine. The New England Journal of Medicine 375 (13): 1216–1219.
Google Scholar
Andreu-Perez, J., C.C. Poon, R.D. Merrifield, S.T. Wong, and G.Z. Yang. 2015. Big data for health. IEEE Journal of Biomedical and Health Informatics 19 (4): 1193–1208.
Google Scholar