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Quantitative analysis of abdominal aortic blood flow by 99mTc-DTPA renal scintigraphy in patients with heart failure

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Abstract

Objective

This study aimed to explore the characteristics of abdominal aortic blood flow in patients with heart failure (HF) using 99mTc-diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy. We investigated the ability of renal scintigraphy to measure the cardiopulmonary transit time and assessed whether the time-to-peak of the abdominal aorta (TTPa) can distinguish between individuals with and without HF.

Methods

We conducted a retrospective study that included 304 and 37 patients with and without HF (controls), respectively. All participants underwent 99mTc-DTPA renal scintigraphy. The time to peak from the abdominal aorta’s first-pass time–activity curve was noted and compared between the groups. The diagnostic significance of TTPa for HF was ascertained through receiver operating characteristic (ROC) analysis and logistic regression. Factors influencing the TTPa were assessed using ordered logistic regression.

Results

The HF group displayed a significantly prolonged TTPa than controls (18.5 [14, 27] s vs. 11 [11, 13] s). Among the HF categories, HF with reduced ejection fraction (HFrEF) exhibited the longest TTPa compared with HF with mildly reduced (HFmrEF) and preserved EF (HFpEF) (25 [17, 36.5] s vs. 17 [15, 23] s vs. 15 [11, 17] s) (P < 0.001). The ROC analysis had an area under the curve of 0.831, which underscored TTPa’s independent diagnostic relevance for HF. The diagnostic precision was enhanced as left ventricular ejection fraction (LVEF) declined and HF worsened. Independent factors for TTPa included the left atrium diameter, LVEF, right atrium diameter, velocity of tricuspid regurgitation, and moderate to severe aortic regurgitation.

Conclusions

Based on 99mTc-DTPA renal scintigraphy, TTPa may be used as a straightforward and non-invasive tool that can effectively distinguish patients with and without HF.

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Funding

This study was supported by National Natural Science Foundation of China (No. 81670357) and medical technology tracking project of Hebei Province (GZ2022049).

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Authors and Affiliations

  1. Heart Failure Center, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang, 050031, Hebei, China

    Yue Li, Zhiqiang Yang, Lizhuo Li, Qingzhen Zhao, Yuzhi Zhen, Yu Wang & Chao Liu

  2. Department of Cardiology, The Second Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, 050000, Hebei, China

    Yue Li

  3. Cardiovascular Research Center of Hebei Medical University, Shijiazhuang, 050000, Hebei, China

    Yue Li & Chao Liu

  4. Health Institute of The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China

    Xian Gao

  5. Division of Nuclear Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China

    Pei Yin

Authors
  1. Yue Li
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  2. Zhiqiang Yang
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  3. Pei Yin
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  4. Xian Gao
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  5. Lizhuo Li
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  6. Qingzhen Zhao
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  7. Yuzhi Zhen
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  8. Yu Wang
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  9. Chao Liu
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Correspondence to Chao Liu.

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Li, Y., Yang, Z., Yin, P. et al. Quantitative analysis of abdominal aortic blood flow by 99mTc-DTPA renal scintigraphy in patients with heart failure. Ann Nucl Med (2024). https://doi.org/10.1007/s12149-024-01912-w

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  • DOI: https://doi.org/10.1007/s12149-024-01912-w

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