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Diagnostic performance of Tc-99m HMPAO SPECT for early and late onset Alzheimer’s disease: a clinical evaluation of linearization correction

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Abstract

Objective

This study examined the influence of linearization correction (LC) on brain perfusion single-photon emission computed tomography (SPECT) for the diagnosis of Alzheimer’s disease (AD).

Methods

The early onset group (<65 years old) consisted of 10 patients with AD, and the late onset group (≥65 years old) of 13 patients with AD. Age-matched controls included seven younger and seven older normal volunteers. Tc-99m hexamethyl propyleneamine oxine (HMPAO) SPECT images were reconstructed with or without LC [LC (+) or LC (−)] and a statistical analysis was performed using a three-dimensional stereotactic surface projection (3D-SSP). In addition, a fully automatic diagnostic system was developed, which calculated the proportion of the number of abnormal pixels in the superior and inferior parietal lobule, as well as in the precuneus and posterior cingulate gyrus.

Results

The areas under the receiver-operating characteristic curve (AUCs) of the early onset group for conventional axial SPECT images, SPECT + 3D-SSP images and the fully automatic diagnostic system were 0.71, 0.88, and 0.92 in LC (−) and 0.67, 0.85, and 0.91 in LC (+), respectively. The AUCs of the late onset group were 0.50, 0.61, and 0.79 in LC (−) and 0.49, 0.67, and 0.85 in LC (+), respectively.

Conclusion

LC on Tc-99m HMPAO SPECT did not significantly influence the diagnostic performance for differentiating between AD and normal controls in either early or late onset AD. Further examination with individuals suffering from very mild dementia is, therefore, expected to elucidate the effect of LC on minimally hypoperfused areas.

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Acknowledgments

The authors thank the staff in the Department of Radiology and Medical Technology, Kyushu University Hospital for their valuable clinical support and also thank Dr. Brian Quinn in Japan Medical Communication Inc. for their editorial assistance.

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Authors and Affiliations

  1. Division of Radiological Science, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Tatsuya Mitsumoto, Yuichi Sakaguchi, Junji Morishita & Masayuki Sasaki

  2. Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan

    Nobuyoshi Ohya

  3. The Institute of Health Science, Kyushu University, Fukuoka, Japan

    Atsushi Ichimiya

  4. Radiological Science Course, Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan

    Aya Kiyota

  5. Department of Radiology, Kyushu University Hospital, Fukuoka, Japan

    Koichiro Abe

Authors
  1. Tatsuya Mitsumoto
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  8. Masayuki Sasaki
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Correspondence to Masayuki Sasaki.

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Mitsumoto, T., Ohya, N., Ichimiya, A. et al. Diagnostic performance of Tc-99m HMPAO SPECT for early and late onset Alzheimer’s disease: a clinical evaluation of linearization correction. Ann Nucl Med 23, 487–495 (2009). https://doi.org/10.1007/s12149-009-0266-0

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  • DOI: https://doi.org/10.1007/s12149-009-0266-0

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