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Tc-99m-MIBI scintigraphy in evaluating the effect of hepatocyte growth factor gene therapy for peripheral arteriosclerosis obliterans

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Abstract

We report an 81-year-old man with arteriosclerosis obliterans with sharp rest pain of the left lower leg below the knee that was resistant to conventional drug therapy. Gene therapy using hepatocyte growth factor (HGF) was performed, following which the symptoms remarkably improved. Magnetic resonance (MR) angiography did not detect any development of collateral vessels following gene therapy; however, technetium-99m-methoxyisobutylisonitrile (Tc-99m)-MIBI scintigraphy revealed the development of micro-circulation in the lower leg following HGF gene therapy. This is the first report on the usefulness of Tc-99m-MIBI scintigraphy to evaluate the effectiveness of HGF gene therapy for peripheral arteriosclerosis obliterans.

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Authors and Affiliations

  1. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Takuji Yamagami, Chio Okuyama & Tsunehiko Nishimura

  2. Division of Cardiovascular Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Keiichi Kanda

Authors
  1. Takuji Yamagami
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  2. Keiichi Kanda
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  3. Chio Okuyama
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  4. Tsunehiko Nishimura
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Correspondence to Takuji Yamagami.

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Yamagami, T., Kanda, K., Okuyama, C. et al. Tc-99m-MIBI scintigraphy in evaluating the effect of hepatocyte growth factor gene therapy for peripheral arteriosclerosis obliterans. Ann Nucl Med 23, 205–208 (2009). https://doi.org/10.1007/s12149-008-0220-6

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  • DOI: https://doi.org/10.1007/s12149-008-0220-6

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