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99mTc-HYNIC octreotide in neuroblastoma

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Abstract

Disease status assessment of neuroblastoma patients requires computed tomography (or magnetic resonance imaging), bone scan, metaiodobenzylguanidine (MIBG) scan, bone marrow tests, and urine catecholamine measurements. There is no clinical experience concerning the evaluation of these patients by means of technetium-99m (99mTc)-somatostatin analog scintigraphy. Furthermore, these radiopharmaceuticals are promising imaging agents owing to their lower cost, availability, dosimetry, and ease of preparation. An 8-year-old boy already diagnosed with stage-IV neuroblastoma received chemotherapy. In the follow-up, after obtaining the parents’ informed consent, iodin 131 (131I)-MIBG and 99mTc-6-hydrazinopyridine-3-carboxylic acid (HYNIC)-octreotide scans were done on separate days to evaluate tumor extension. Even as the 131I-IBG scan showed mild diffuse uptake in the projection of both lung hili, the 99mTc-HYNIC-octreotide scan showed multiple axial and appendicular bone uptakes and paravertebral, abdominal, mediastinal, and supraclavicular ganglionar uptakes. The 99mTc-HYNIC-octreotide showed much more lesion extension than the 131I-MIBG. Therefore, 99mTc-HYNIC-octreotide may be a promising radiopharmaceutical for the evaluation of neuroblastoma patients. This finding justifies the pre liminary evaluation of this tracer in the context of a clinical trial.

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Authors and Affiliations

  1. Nuclear Medicine Center, Clinical Hospital, University of Uruguay, Av. Italia s/n, C.P. 11600, Montevideo, Uruguay

    Juan P. Gambini, Juan J. López Lerena, Adriana Quagliata, Juan C. Hermida, Carlos Heuguerot & Omar Alonso

  2. Nuclear Medicine Department, IMPASA, Montevideo, Uruguay

    Juan J. López Lerena, Adriana Quagliata, Juan C. Hermida & Carlos Heuguerot

Authors
  1. Juan P. Gambini
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  2. Juan J. López Lerena
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  3. Adriana Quagliata
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  4. Juan C. Hermida
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  5. Carlos Heuguerot
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  6. Omar Alonso
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Correspondence to Omar Alonso.

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Gambini, J.P., López Lerena, J.J., Quagliata, A. et al. 99mTc-HYNIC octreotide in neuroblastoma. Ann Nucl Med 22, 817–819 (2008). https://doi.org/10.1007/s12149-008-0201-9

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  • DOI: https://doi.org/10.1007/s12149-008-0201-9

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