Abstract
Objective
The relationships among regional diastolic impairment, the elongation of global time to peak filling rate (g-TPF), and global diastolic function were examined by a novel program using electrocardiography-gated myocardial perfusion single-photon emission computed tomography (SPECT) (GMPS) in heart failure (HF).
Methods
Fifteen control subjects and 70 HF patients, New York Heart Association functional classification I (N-1) 41 cases, classification II (N-II) 15 cases, and classification III (N-III) 14 cases, were examined by GMPS. Using the reference mean +2 SD (standard deviation) of g-TPF derived from control group (CG), HF patients were divided into a normal g-TPF group (NG) and elongated g-TPF group (EG). The distributions of g-TPF and regional (r-) TPF were estimated by histograms. The extension of regional diastolic impairment was estimated by the number of r-TPF elongated segments (NES).
Results
g-TPF and r-TPF mainly distributed from 100 ms to 220 ms and demonstrated a peak around 150 ms in CG and NG. g-TPF distributed from 240 ms to 560 ms, but r-TPF distributed from 90 ms to 690 ms and demonstrated two peaks around 150 ms and 350 ms in EG. NES significantly correlated with g-TPF (r = 0.79, P = 6 × 10−10 in N-I; r = 0.69 and P < 0.005 in N-II; r = 0.89, P = 2 × 10−5 in N-III). NES negatively correlated with first third filling fraction (1/3FF) (r = −0.83, P = 3 × 10−11 in N-I; r = −0.72, P < 0.0005 in N-II) and first third filling rate (1/3FR) (r = −0.49, P = 0.002 in N-I; r = −0.52, P = 0.002 in N-II; r = −0.81, P < 0.0005 in N-III). g-TPF significantly correlated with 1/3FF (r = −0.67, P = 1.5 × 10−6 in N-I; r = −0.69, P < 0.005 in N-II) and 1/3FR (r = −0.41, P < 0.01 in N-I; r = −0.69, P < 0.01 in N-III).
Conclusions
The development of regional early diastolic impairment makes g-TPF elongation and induces global dysfunction in early diastole.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
WG Grossman (2000) ArticleTitleDefining diastolic dysfunction Circulation 101 2020–1 Occurrence Handle10790339 Occurrence Handle1:STN:280:DC%2BD3c3ltlOktA%3D%3D
RS Vasan D Levy (2000) ArticleTitleDefining diastolic heart failure: a call for standardized diagnostic criteria Circulation 101 2118–21 Occurrence Handle10790356 Occurrence Handle1:STN:280:DC%2BD3c3ltlOqsQ%3D%3D
M Kidawa L Coignard G Drobinski MK Pakula D Thomas M Kotnajda et al. (2005) ArticleTitleComparative value of tissue Doppler imaging and M-mode color Doppler mitral flow propagation velocity for the evaluation of left ventricular filling pressure Chest 128 2544–50 Occurrence Handle16236921 Occurrence Handle10.1378/chest.128.4.2544
Y Hadano K Murata J Liu R Oyama N Harada S Okuda Y Hamada et al. (2005) ArticleTitleCan transthoracic Doppler echocardiography predict the discrepancy between left ventricular end-diastolic pressure and mean pulmonary capillary wedge pressure in patients with heart failure? Circ J 69 432–8 Occurrence Handle15791038 Occurrence Handle10.1253/circj.69.432
C Akincioglu DS Berman H Nishina PB Kavanagh P Slomka A Abidov et al. (2005) ArticleTitleAssessment of diastolic function using 16-frame 99mTc-Sestamibi gated myocardial perfusion SPECT: normal values J Nucl Med 46 1102–8 Occurrence Handle16000278
M Ohno CP Cheng WC Little (1994) ArticleTitleCongestive heart failure: mechanism of altered patterns of left ventricular filling during the development of congestive heart failure Circulation 89 2241–50 Occurrence Handle8181149 Occurrence Handle1:STN:280:DyaK2c3js1Orug%3D%3D
A Yamamoto T Hosoya N Takahashi S Iwahara K Munakata (2006) ArticleTitleQuantification of left ventricular regional functions using ECG-gated myocardial perfusion SPECT—validation of left ventricular systolic functions Ann Nucl Med 20 449–56 Occurrence Handle17037276 Occurrence Handle10.1007/BF02987253
A Yamamoto N Takahashi K Munakata T Hosoya M Shiiba T Okuyama et al. (2007) ArticleTitleGlobal and regional evaluation of systolic and diastolic left ventricular temporal parameters using a novel program for ECG-gated myocardial perfusion SPECT—validation by comparison with gated equilibrium radionuclide angiography and speckle-tracking radial strain from echocardiography Ann Nucl Med 21 115–21 Occurrence Handle17424978
T Nakata Y Katagiri Y Odawara M Eguchi K Masatoshi K Tsuchihashi et al. (2000) ArticleTitleTwo- and three-dimensional assessment of myocardial perfusion and function by using technetium-99m sestamibi gated SPECT with a combination of count and image-based techniques J Nucl Cardiol 7 623–32 Occurrence Handle11144477 Occurrence Handle10.1067/mnc.2000.109271 Occurrence Handle1:STN:280:DC%2BD3M7it1yksQ%3D%3D
A Hashimoto T Nakata T Wakabayashi M Kyuma T Takahashi K Tsuchihashi et al. (2002) ArticleTitleValidation of quantitative gated single photon emission computed tomography and an automated scoring system for the assessment of regional left ventricular systolic function Nucl Med Commun 23 887–98 Occurrence Handle12195094 Occurrence Handle10.1097/00006231-200209000-00013 Occurrence Handle1:CAS:528:DC%2BD38Xntlyhsbk%3D
InstitutionalAuthorNameAmerican Heart Association Working group (2002) ArticleTitleStandardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council Cardiology of the American Heart Association Circulation 105 539–42 Occurrence Handle10.1161/hc0402.102975
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yamamoto, A., Takahashi, N., Munakata, K. et al. Relationships among regional diastolic impairment, elongation of global time to peak filling rate, and global diastolic function using ECG-gated myocardial perfusion SPECT in heart failure. Ann Nucl Med 21, 419–427 (2007). https://doi.org/10.1007/s12149-007-0046-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12149-007-0046-7