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Clinical usefulness of a novel program “Heart Function View” for evaluating cardiac function from gated myocardial perfusion SPECT

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Abstract

Objective

To investigate clinical usefulness of a novel program “Heart Function View (HFV)” for evaluating left ventricular (LV) function from myocardial perfusion SPECT (MPS), we compared LV functional parameters (F(x)) calculated by HFV with those obtained by the other similar programs QGS and cardioGRAF or by ultrasound echocardiography (UCG) and examined their correlations with clinical markers of heart failure: plasma BNP concentrations (BNPs) and exercise capacity.

Methods

Studied patients (n = 60) underwent technetium-99m tetrofosmin quantitative gated MPS including treadmill exercise for examining heart disease. Myocardial stress images were acquired 30 min after the first tracer injection during maximal exercise. Three hours later, the second tracer was injected, and resting images were acquired. LV systolic F(x) [ejection fraction (EF), peak ejection rate (PER)] and diastolic F(x) [first third filling fraction (1/3FF), first third filling rate (1/3FR), peak filling rate (PFR), time to PFR (TPF)] were analyzed, and phase standard deviation (SD) and histogram bandwidth were obtained by phase analysis.

Results

LV end-diastolic volume (EDV), end-systolic volume (ESV) and EF obtained from HFV were well correlated with those from QGS, cardioGRAF and UCG. A diastolic parameter Doppler E/e′ from UCG was significantly with PFR from HFV. There were good correlations between LVEDV, LVESV, LVEF, PER, PFR, 1/3FR, TPF and 1/3FF from HFV and those from cardioGRAF. LVEF, PER, 1/3FR, and PFR were significantly correlated with plasma BNP concentrations. In patients with non-ischemic heart disease (n = 42), phase SD and histogram bandwidth were correlated negatively with exercise capacity or PFR.

Conclusions

HFV-derived LVF(x) are correlated with LVF(x) from the other programs or UCG, or with the clinical markers of heart failure and are thus useful in the functional assessment for patients with heart disease.

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Abbreviations

AF:

Atrial fibrillation

BNP:

B-type natriuretic peptide

BNPs:

Plasma B-type natriuretic peptide concentrations

ECG:

Electrocardiography/electrocardiogram

EDV:

End-diastolic volume

E/e′:

Tissue Doppler diastolic functional indicator

EF:

Ejection fraction

ESV:

End-systolic volume

1/3FF:

First third filling fraction

1/3FR:

First third filling rate

F(x):

Functional parameters

HFV:

Heart function view

LBBB:

Left bundle branch block

LV:

Left ventricle or ventricular

MPS:

Myocardial perfusion SPECT

PER:

Peak ejection rate

PFR:

Peak filling rate

QGS:

Quantitative gated SPECT

SD:

Standard deviation

SDS:

Summed difference score

SPECT:

Single photon emission computed tomography

SRS:

Summed rest score

SSS:

Summed stress score

TPF:

Time to peak filling

UCG:

Ultrasound echocardiography

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Authors and Affiliations

  1. Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan

    Ichiro Nakae & Minoru Horie

  2. Department of Physical Medicine and Rehabilitation, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan

    Hideki Hayashi

  3. Department of Health and Life Sciences, Osaka Kyoiku University, Osaka, Japan

    Tetsuya Matsumoto

  4. Vories Memorial Hospital, Shiga, Japan

    Kenichi Mitsunami

Authors
  1. Ichiro Nakae
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  2. Hideki Hayashi
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  3. Tetsuya Matsumoto
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  4. Kenichi Mitsunami
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  5. Minoru Horie
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Correspondence to Ichiro Nakae.

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Nakae, I., Hayashi, H., Matsumoto, T. et al. Clinical usefulness of a novel program “Heart Function View” for evaluating cardiac function from gated myocardial perfusion SPECT. Ann Nucl Med 28, 812–823 (2014). https://doi.org/10.1007/s12149-014-0875-0

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  • DOI: https://doi.org/10.1007/s12149-014-0875-0

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