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Associations between obstructive sleep apnea and cardiac troponin T levels: a meta-analysis

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Abstract

Cardiac troponin T (cTnT) is a sensitive indicator of heart damage and an important clinical marker for acute myocardial infarction (MI). The recent development of a high-sensitivity cardiac troponin T (hs-cTnT) assay allows a more accurate diagnosis of serum cTnT level. There appears to be an association between Obstructive Sleep Apnea (OSA) and changes in serum cTnT level. However, existing research shows mixed results. Therefore, this meta-analysis was performed to evaluate the relationship between cTnT level and OSA. The Scopus, EMBASE, Web of Science, PubMed and Science Direct databases were searched without a lower time limit and until April 2020. In order to perform the meta-analysis, the heterogeneity of articles was examined using the I2 test, and subsequently a random effects model was applied. Data analysis was performed within the Comprehensive Meta-Analysis software (version 2). Six studies comprising of 1689 cases and 2171 controls were included in this meta-analysis. The odds ratio of cTnT level in patients with OSA is 1.25 (95% confidence interval: 0.97–1.61), indicating that OSA patients have 25% higher odds to develop cTnT level than people without OSA. Our study showed that OSA is associated with higher serum hs-cTnT level compared to individuals with no OSA. Given that elevated cTnT level can indicate cardiovascular disease, these individuals should be prioritized for screening, early detection and swift interventions. Further studies are needed to determine the causality of this association.

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Data Availability

Datasets are available through the corresponding author upon reasonable request.

Abbreviations

OSA:

Obstructive Sleep Apnea

CVD:

Cardiovascular Diseases

CAD:

Coronary Artery Disease

Hs-cTnT:

Highly-sensitive cardiac Troponin T

RDI:

Respiratory Disturbance Index

AHI:

Apnea-Hypopnea Index

STROBE:

Strengthening the Reporting of Observational studies in Epidemiology

BMI:

Body Mass Index

ODI:

Oxygen Saturation Index

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analyses

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Acknowledgements

The authors thank the Student Research Committee of Kermanshah University of Medical Sciences.

Authors’contributions

NS and HKH and BKH and ASH and MM contributed to the design, MM statistical analysis, participated in most of the study steps. AHF and HGH and SHR1 and SHR2 and MM prepared the manuscript. SHR1 and MM and HG and SHR2 assisted in designing the study, and helped in the, interpretation of the study. All authors have read and approved the content of the manuscript.

Funding

By Deputy for Research and Technology, Kermanshah University of Medical Sciences (IR) (3011584). This deputy has no role in the study process.

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Authors and Affiliations

  1. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Nader Salari, Behnam Khaledi-Paveh & Habibolah Khazaie

  2. Department of Business Systems & Operations, University of Northampton, Northampton, UK

    Amin Hosseinian-Far

  3. Department of Medicine, Pulmonary, Critical Medicine and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA

    Amir Sharafkhaneh

  4. Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran

    Masoud Mohammadi

  5. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Hooman Ghasemi

  6. Department of Psychiatric Nursing, School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, Iran

    Shabnam Rasoulpoor

  7. Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Shna Rasoulpoor

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  1. Nader Salari
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  9. Habibolah Khazaie
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Correspondence to Masoud Mohammadi.

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Salari, N., Hosseinian-Far, A., Sharafkhaneh, A. et al. Associations between obstructive sleep apnea and cardiac troponin T levels: a meta-analysis. Curr Psychol 42, 20707–20717 (2023). https://doi.org/10.1007/s12144-022-03217-5

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