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A Novel Gene Fusion YLPM1::PRKD1 Identified in a Cribriform Subtype of Polymorphous Adenocarcinoma

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Abstract

Cribriform adenocarcinoma of the salivary gland (CASG) is an entity that is currently classified under polymorphous adenocarcinoma (PAC), cribriform subtype per the 2022 WHO classification of head and neck tumours. There is debate about whether CASG should be considered a separate diagnostic entity, as CASG differs from conventional PAC in anatomic site, clinical behaviors, and molecular patterns. Herein we describe a challenging and unique case which shares histologic and behavioral features between CASG and conventional PAC with a YLPM1::PRKD1 rearrangement not previously reported in the literature.

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Authors and Affiliations

  1. Department of Pathology, Stanford University School of Medicine, Stanford, USA

    Monica Miyakawa-Liu, Michael G Ozawa & Mobeen Rahman

  2. Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, USA

    Michelle Chen

Authors
  1. Monica Miyakawa-Liu
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  2. Michael G Ozawa
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  3. Michelle Chen
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  4. Mobeen Rahman
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Contributions

M.M-L and M.R. wrote the main manuscript text. M.R. and M.O. provided the pathology diagnoses. M.C. provided the clinical information. All authors reviewed the manuscript.

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Correspondence to Monica Miyakawa-Liu.

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Miyakawa-Liu, M., Ozawa, M.G., Chen, M. et al. A Novel Gene Fusion YLPM1::PRKD1 Identified in a Cribriform Subtype of Polymorphous Adenocarcinoma. Head and Neck Pathol 18, 43 (2024). https://doi.org/10.1007/s12105-024-01648-z

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  • DOI: https://doi.org/10.1007/s12105-024-01648-z

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