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Oral localized amyloidosis

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Abstract

This report describes two cases of oral localized amyloidosis (LA). In case 1, a 52-year-old man appeared with painful slightly, yellowish multiple nodules located on the dorsum of the tongue, of unknown duration. Incisional biopsy was performed, and the histopathologic analysis revealed a homogeneous, eosinophilic, and extracellular material. Congo red stain showed salmon pink coloration at light microscopy and apple-green birefringence at polarized light. In case 2, a 74-year-old man presented asymptomatic nodular lesions on the labial commissures with duration of several months. An excisional biopsy was performed in both lesions, and microscopically the specimen demonstrated the same histopathologic features of the case 1. Furthermore, amyloidosis with systemic involvement was excluded after investigations for both patients. Thus, the final diagnosis for both cases was LA. The patient 1 refused the surgical excision of the residual lesion, and in both cases, no signs of clinical and systemic progression were observed after 24 and 84 months of follow up. Although it is rare, LA should be considered in the differential diagnosis of multiple or single yellowish nodules on the oral cavity.

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References

  1. Fahrner KS, Black CC, Gosselin BJ. Localized amyloidosis of the tongue: a review. Am J Otolaryngol. 2004;25(3):186–9. doi:https://doi.org/10.1016/j.amjoto.2004.01.007.

    Article  PubMed  Google Scholar 

  2. Cengiz MI, Wang HL, Yıldız L. Oral involvement in a case of AA amyloidosis: a case report. J Med Case Rep. 2010;4:200. doi:https://doi.org/10.1186/1752-1947-4-200.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Cohen AS, Calkins E. Electron microscopic observations on a fibrous component in amyloid of diverse origins. Nature. 1959;183(4669):1202–3. doi:https://doi.org/10.1038/1831202a0.

    Article  CAS  PubMed  Google Scholar 

  4. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med. 1997;337(13):898–909. doi:https://doi.org/10.1056/NEJM199709253371306.

    Article  CAS  PubMed  Google Scholar 

  5. Pentenero M, Davico Bonino L, Tomasini C, Conrotto D, Gandolfo S. Localized oral amyloidosis of the palate. Amyloid. 2006;13(1):42–6. https://doi.org/10.1080/13506120500537343.

    Article  CAS  PubMed  Google Scholar 

  6. Balatsouras DG, Eliopoulos P, Assimakopoulos D, Korres S. Primary local amyloidosis of the palate. Otolaryngol Head Neck Surg. 2007;137(2):348–9. doi:https://doi.org/10.1016/j.otohns.2007.03.039.

    Article  PubMed  Google Scholar 

  7. Aono J, Yamagata K, Yoshida H. Local amyloidosis in the hard palate: a case report. Oral Maxillofac Surg. 2009;13(2):119–22. doi:https://doi.org/10.1007/s10006-009-0158-4.

    Article  PubMed  Google Scholar 

  8. Pang KP, Chee LWJ, Busmanis I. Amyloidoma of the nose in a pediatric Patient: a case report. Am J Otolaryngol. 2001;22(2):138–41. doi:https://doi.org/10.1053/ajot.2001.22576.

    Article  CAS  PubMed  Google Scholar 

  9. Babburi S, B R, Rv S, Srivastava VA G. Amyloidosis of the tongue – report of a rare case. J Clin Diagn Res. 2013;7(12):3094-5. Doi: https://doi.org/10.7860/JCDR/2013/7028.3865.

  10. Stoor P, Suuronen R, Lindqvist C, Hietanen J, Laine P. Local primary (AL) amyloidosis in the palate. A case report. Int J Oral Maxillofac Surg. 2004;33(4):402–3. doi:https://doi.org/10.1016/j.ijom.2003.08.010.

    Article  CAS  PubMed  Google Scholar 

  11. Yamagata K, Bukawa H. Oral localized amyloidosis. In: Güvenç IA ed. Amyloidosis-an insight to disease of systems and novel therapies. London: IntechOpen; 2011. pp. 141–52. doi:https://doi.org/10.5772/1785.

  12. Haraguchi H, Ohashi K, Yamada M, Hasegawa M, Maeda S, Komatsuzaki A. Primary localized nodular tongue amyloidosis associated with Sjögren’s syndrome. J Otorhinolaryngol Relat Spec. 1997;59(1):60–3. doi:https://doi.org/10.1159/00027690.

    Article  CAS  Google Scholar 

  13. Koren R, Veltman V, Halpern M, Szabo R, Gal R. Localized amyloid tumor of the tongue. A case report and review of the literature. Rom J Morphol Embryol. 1998;44(1–4):179–82.

    CAS  PubMed  Google Scholar 

  14. Asaumi J, Yanagi Y, Hisatomi M, Konouchi H, Kishi K. CT and MR imaging of localized amyloidosis. Eur J Radiol. 2001;39(2):83–7. doi:https://doi.org/10.1016/s0720-048x(01)00300-x.

    Article  CAS  PubMed  Google Scholar 

  15. Singh A, Haq M, Gautam P, Gautam D, Handa AC, Handa KK. Clinical Profile of Patients with Head and Neck Amyloidosis: A Single-Institution Retrospective Chart Review. Int Arch Otorhinolaryngol. 2020;24(4):e450–6. doi:https://doi.org/10.1055/s-0039-3402494.

    Article  PubMed  PubMed Central  Google Scholar 

  16. O’Reilly A, D’Souza A, Lust J, Price D. Localized tongue amyloidosis: a single institutional case series. Otolaryngol Head Neck Surg. 2013;149(2):240–4. doi:https://doi.org/10.1177/0194599813490896.

    Article  PubMed  Google Scholar 

  17. McAlpine JC, Fuller AP. Localized laryngeal amyloidosis, a report of a case with a review of the literature. J Laryngol Otol. 1964;78:296–314. doi:https://doi.org/10.1017/s0022215100062113.

    Article  CAS  PubMed  Google Scholar 

  18. Yamoaka Y, Suzuki A, Hatakeyama S, Noda M, Hiraga M, Sekiyama S. Median rhomboid glossitis associated with amyloid deposition. Act Pathol Jpn. 1978;23:319–23. doi:https://doi.org/10.1111/j.1440-1827.1978.tb00544.x.

    Article  Google Scholar 

  19. Liu X, Zhou P, Hua H. Characteristics of Orofacial Amyloidosis: A Case Series. Ann Clin Case Rep. 2016;1:1133.

    Google Scholar 

  20. Noguchi T, Jinbu, Sakurai S. Kusama. Primary Localized Amyloidosis of the Angle of Mouth: Report of a case. Oral Med Pathol. 2003;8(1):27–30. doi:https://doi.org/10.3353/omp.8.27.

    Article  Google Scholar 

  21. Silva WPP, Wastner B, Bohn JC, Jung JE, Schussel JL, Sassi LM. Unusual presentation of oral amyloidosis. Contemp Clin Dent. 2015;6(1):282-4. doi:https://doi.org/10.4103/0976-237X.166814.

    Article  CAS  Google Scholar 

  22. Timoşca G, Gavriliţă L. Primary localized amyloidosis of the palate. Oral Surg. 1977;44(1):76–83. doi:https://doi.org/10.1016/0030-4220(77)90247-x.

    Article  PubMed  Google Scholar 

  23. Rennie JS, Critchlow HA. Solitary oral amyloid. A report of two cases. Int J Oral Surg. 1982;11(1):73–6. doi:https://doi.org/10.1016/s0300-9785(82)80053-7.

    Article  CAS  PubMed  Google Scholar 

  24. Takeda Y, Sekiyama S, Suzuki A, Hirose H. Localized oral amyloidosis: ultrastructural and immunohistochemical study. J Oral Pathology. 1987;16(5):278–81. doi:https://doi.org/10.1111/j.1600-0714.1987.tb01493.x.

    Article  CAS  Google Scholar 

  25. Madani M, Harwick RD, Chen SY, Miller AS. Amyloidosis of the oral cavity: report of five cases. Compendium. 1991;12(5):336. 338 – 42.

    CAS  PubMed  Google Scholar 

  26. Kerner MM, Wand MD, Angier G, Calcaterra TC, Ward PH. Amyloidosis of the head and neck—a clinicopathologic study of the UCLA experience. Arch Otolaryngol Head Neck Surg. 1995;121(7):778–82. doi:https://doi.org/10.1001/archotol.1995.01890070064014.

    Article  CAS  PubMed  Google Scholar 

  27. Alvi A, Goldstein MN. Amyloidosis of the palate. Otolaryngol Head Neck Surg. 1999;120(2):287. doi:https://doi.org/10.1016/S0194-5998(99)70424-9.

    Article  CAS  PubMed  Google Scholar 

  28. Penner CR, Muller S. Head and neck amyloidosis: a clinicopathologic study of 15 cases. Oral Oncol. 2006;42(4):421–9. doi:https://doi.org/10.1016/j.oraloncology.2005.09.010.

    Article  PubMed  Google Scholar 

  29. Henley E, Houghton N, Bucknall R, Triantafyllou A, Field EA. Localized amyloidosis of the palate. Clin Exp Dermatol. 2008;33(1):100–1. doi:https://doi.org/10.1111/j.1365-2230.2007.02528.x.

    Article  CAS  PubMed  Google Scholar 

  30. Akyildiz S, Doganavsargil B, Göde S, Veral A. Solitary amyloid tumor of the tongue base. Int J Otolaryngol. 2009;2009:515068. doi:https://doi.org/10.1155/2009/515068.

    Article  PubMed Central  Google Scholar 

  31. Angiero F, Seramondi R, Magistro S, Crippa R, Benedicenti S, Rizzardi C, Cattoretti G. Amyloid deposition in the tongue: clinical and histopathological profile. Anticancer Res. 2010;30(7):3009–14.

    PubMed  Google Scholar 

  32. Andreadis D, Poulopoulos A, Papadopoulos P, Epivatianos A. Localized tongue amyloidosis in a patient with neurofibromatosis type II. Head Neck Pathol. 2011;5(3):302–5. doi:https://doi.org/10.1007/s12105-011-0251-5.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Gouvêa AF, Ribeiro ACP, Léon JE, Carlos R, De Almeida OP, Lopes MA. Head and neck amyloidosis: clinicopathological features and immunohistochemical analysis of 14 cases. J Oral Pathol Med. 2012;41(2):178–85. doi:https://doi.org/10.1111/j.1600-0714.2011.01073.x.

    Article  PubMed  Google Scholar 

  34. Bucci T, Bucci E, Rullan AMP, Bucci P, Nuzzolo. Localized amyloidosis of the upper gingiva: a case report. J Med Case Rep. 2014;8:198. doi:https://doi.org/10.1186/1752-1947-8-198.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Folkard SS, Gibbs SD, Shah KA, Dhariwak DK. A rare case of localized oral amyloid of the labial mucosa. Br J Oral Maxillofac Surg. 2014;52(4):e24–5. doi:https://doi.org/10.1016/j.bjoms.2014.01.014.

    Article  PubMed  Google Scholar 

  36. Matsuo FS, De Paulo LFB, Servato JPS, De Faria PR, Cardoso SV, Loyola AM. Involvement of oral tissue by AL amyloidosis: a literature review and report of eight new cases. Clin Oral Invest. 2016;20(8):1913–20. doi:https://doi.org/10.1007/s00784-015-1649-3.

    Article  Google Scholar 

  37. Adamo D, Gasparro R, Marenzi G, Mascolo M, Cervasio M, Cerciello G, De Novellis D, Mignogna MD. Amyloidoma of the tongue: case report, surgical management, and review of the literature. J Oral Maxillofac Surg. 2020;78(9):1572–82. doi:https://doi.org/10.1016/j.joms.2020.04.022.

    Article  PubMed  Google Scholar 

  38. Morelato L, Smojver I, Seiwerth S, Gabric D. Extremely rare intraoral presentation of localized amyloidosis. Case Rep Dent. 2021;2021:5541320. doi: https://doi.org/10.1155/2021/5541320.

  39. Thompson LDR, Deringer GA, Wenig BM. Amyloidosis of the larynx: a clinicopathologic study of 11 cases. Mod Pathol. 2000;13(5):528–35. doi:https://doi.org/10.1038/modpathol.3880092.

    Article  CAS  PubMed  Google Scholar 

  40. Deng J, Chen Q, Ji P, Zeng X, Jin X. Oral amyloidosis: A strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis. Oral Dis. 2019;25(3):670–5. doi:https://doi.org/10.1111/odi.12870.

    Article  CAS  PubMed  Google Scholar 

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Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil.

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Authors and Affiliations

  1. Department of Clinical and Preventive Dentistry, Oral Pathology Unit, Federal University of Pernambuco, Recife, Pernambuco, Brazil

    Hélen Kaline Farias Bezerra, Elaine Judite de Amorim Carvalho DDS, PhD & Danyel Elias da Cruz Perez DDS, PhD

  2. School of Dentistry, Uninassau, Recife, Pernambuco, Brazil

    Talita Ribeiro Tenório de França DDS, PhD

  3. Department of Stomatology, A. C. Camargo Cancer Center, São Paulo, São Paulo, Brazil

    José Divaldo Prado DDS

  4. Andalusian Healthcare Service, Department of Medical and Surgical Specialties, University of Córdoba, Córdoba, Spain

    Rafael Segura Saint-Gerons DDS, PhD

  5. Department of Clinical and Preventive Dentistry, Oral Pathology Unit, Universidade Federal de Pernambuco, 4ª Travessa Professor Artur de Sá, s/n, CEP: 50740-521, Recife, PE, Brazil

    Danyel Elias da Cruz Perez DDS, PhD

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  1. Hélen Kaline Farias Bezerra
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Contributions

Conceptualization: Danyel Elias da Cruz Perez; José Divaldo Prado; Rafael Segura Saint-Gerons. Supervision: Danyel Elias da Cruz Perez; José Divaldo Prado. Visualization: Elaine Judite de Amorim Carvalho. Writing – original draft: Hélen Kaline Farias Bezerra; Talita Ribeiro Tenório de França. Writing – review & editing: Danyel Elias da Cruz Perez; Elaine Judite de Amorim Carvalho; Rafael Segura Saint-Gerons.

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Correspondence to Danyel Elias da Cruz Perez DDS, PhD.

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Bezerra, H.K.F., de França, T.R.T., Prado, J.D. et al. Oral localized amyloidosis. Head and Neck Pathol 16, 818–822 (2022). https://doi.org/10.1007/s12105-022-01436-7

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